2011
Open-Label Randomized Trial of the Safety and Efficacy of a Single Dose Conivaptan to Raise Serum Sodium in Patients with Traumatic Brain Injury
Galton C, Deem S, Yanez ND, Souter M, Chesnut R, Dagal A, Treggiari M. Open-Label Randomized Trial of the Safety and Efficacy of a Single Dose Conivaptan to Raise Serum Sodium in Patients with Traumatic Brain Injury. Neurocritical Care 2011, 14: 354-360. PMID: 21409494, DOI: 10.1007/s12028-011-9525-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntidiuretic Hormone Receptor AntagonistsBenzazepinesBrain InjuriesDiuresisFemaleHumansIntracranial PressureMaleMiddle AgedSodiumTreatment OutcomeConceptsTraumatic brain injurySevere traumatic brain injuryUsual care groupIntracranial pressureSerum sodiumAdverse eventsUrine outputCare groupSodium loadBrain injuryDrug-related serious adverse eventsEffects of conivaptanLabel Randomized TrialNon-hyponatremic patientsSerum sodium increaseSerious adverse eventsTreatment of hyponatremiaSodium increasesMethodsOpen-labelNormonatremic patientsPrimary endpointResultsTen patientsSecondary endpointsUsual careMean sodium
2009
Management guided by brain tissue oxygen monitoring and outcome following severe traumatic brain injury.
Martini RP, Deem S, Yanez ND, Chesnut RM, Weiss NS, Daniel S, Souter M, Treggiari MM. Management guided by brain tissue oxygen monitoring and outcome following severe traumatic brain injury. Journal Of Neurosurgery 2009, 111: 644-9. PMID: 19392603, DOI: 10.3171/2009.2.jns08998.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain InjuriesCohort StudiesFemaleHealth ResourcesHospital CostsHospital MortalityHumansIntracranial PressureLength of StayMaleMiddle AgedMonitoring, PhysiologicOxygenPrognosisRegression AnalysisRespiration, ArtificialRetrospective StudiesTrauma Severity IndicesTreatment OutcomeConceptsBrain tissue oxygen monitoringHospital mortality rateTissue oxygen monitoringTraumatic brain injurySevere traumatic brain injuryMortality rateBrain injuryHospital lengthNeurological outcomeHospital dischargeClinical managementICP monitoringMedian hospital lengthWorse neurological outcomeHospital resource utilizationOxygen monitoringMain outcome measuresFunctional Independence ScoreIntracranial pressure monitoringSeverity of injuryBaseline characteristicsCohort studyPatient ageMore patientsOsmotic therapy
2007
Role of intracranial pressure values and patterns in predicting outcome in traumatic brain injury: a systematic review
Treggiari MM, Schutz N, Yanez ND, Romand JA. Role of intracranial pressure values and patterns in predicting outcome in traumatic brain injury: a systematic review. Neurocritical Care 2007, 6: 104-112. PMID: 17522793, DOI: 10.1007/s12028-007-0012-1.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesHumansIntracranial HypertensionIntracranial PressureOutcome Assessment, Health CarePredictive Value of TestsConceptsNeurological outcomePoor neurological outcomeIntracranial pressureICP valuesOdds ratioICP patternsLong-term outcomesNormal intracranial pressureSummary odds ratiosTraumatic brain injuryAbsolute ICP valuesIntracranial pressure valuesRegistry searchMethodsSystematic reviewProspective studyBrain injuryRelative riskICP monitoringMethodological qualityMAIN OUTCOMEReference listsSystematic reviewLogistic regressionICP 20Outcomes