2024
Association of early dexmedetomidine exposure with brain injury biomarker levels following moderate – Severe traumatic brain injury: A TRACK-TBI study
Wongsripuemtet P, Ohnuma T, Temkin N, Barber J, Komisarow J, Manley G, Hatfield J, Treggiari M, Colton K, Sasannejad C, Chaikittisilpa N, Ivins-O’Keefe K, Grandhi R, Laskowitz D, Mathew J, Hernandez A, James M, Raghunathan K, Miller J, Vavilala M, Krishnamoorthy V, investigators T. Association of early dexmedetomidine exposure with brain injury biomarker levels following moderate – Severe traumatic brain injury: A TRACK-TBI study. Journal Of Clinical Neuroscience 2024, 126: 338-347. PMID: 39029302, DOI: 10.1016/j.jocn.2024.07.003.Peer-Reviewed Original ResearchConceptsC-reactive proteinNeuron-specific enolaseGlial fibrillary acidic proteinBiomarker levelsUbiquitin C-terminal hydrolase-L1Traumatic brain injuryDexmedetomidine exposureInjury biomarkersSevere traumatic brain injuryTRACK-TBIS100 calcium-binding protein BInflammatory biomarkers C-reactive proteinCalcium-binding protein BHs-CRP levelsLevel 1 trauma centerRetrospective cohort studyCritically ill TBI patientsAlpha-2 agonistsBrain injuryBrain injury biomarkersBiomarkers C-reactive proteinModulate autonomic functionGlasgow Coma Scale score 3No significant associationSecondary brain injury
2016
Comparison of enteral ethanol and benzodiazepines for alcohol withdrawal in neurocritical care patients
Gipson G, Tran K, Hoang C, Treggiari M. Comparison of enteral ethanol and benzodiazepines for alcohol withdrawal in neurocritical care patients. Journal Of Clinical Neuroscience 2016, 31: 88-91. PMID: 27262870, DOI: 10.1016/j.jocn.2016.02.028.Peer-Reviewed Original ResearchConceptsEnteral ethanolCIWA scoreAlcohol withdrawalEthanol groupIntensive care unit lengthClinical Institute Withdrawal AssessmentAlcohol withdrawal managementRetrospective chart reviewNeurocritical care patientsGlasgow Coma ScaleLength of stayUse of benzodiazepinesLevel of comaAlcohol scale scoresPrimary endpointSecondary endpointsChart reviewClinical characteristicsFirst medicationCare patientsComa ScaleOral intakeEthanol withdrawalWithdrawal AssessmentNeurocritical care