2024
Contemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist
Robba C, Busl K, Claassen J, Diringer M, Helbok R, Park S, Rabinstein A, Treggiari M, Vergouwen M, Citerio G. Contemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist. Intensive Care Medicine 2024, 50: 646-664. PMID: 38598130, PMCID: PMC11078858, DOI: 10.1007/s00134-024-07387-7.Peer-Reviewed Original ResearchConceptsIntensive care unitAneurysmal subarachnoid haemorrhageRuptured aneurysmsLong-term prognostic factorsRisk of rebleedingIntensive care unit managementRobust clinical evidenceDelayed cerebral ischaemiaExpert clinical experienceSecondary brain damageDeterminants of functional outcomePrognostic factorsASAH patientsPrompt diagnosisHaemodynamic monitoringClinical evidenceMorbidity rateSpecialized centersTreatment strategiesClinical trialsContemporary guidelinesPatient populationFunctional outcomesCare unitCerebral ischaemia
2021
Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study
Zhao X, Gao C, Dai F, Treggiari MM, Deshpande R, Meng L. Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study. Anesthesiology 2021, 135: 1076-1090. PMID: 34597362, DOI: 10.1097/aln.0000000000003999.Peer-Reviewed Original ResearchConceptsIll COVID-19 patientsCOVID-19 patientsPropensity score-matched analysisRetrospective cohort studyLower mortalityHospital mortalityCohort studyMultivariable analysisYale New Haven Health SystemIntensive care unit admissionOrgan support treatmentUse of apixabanCare unit admissionSevere COVID-19Intensive care unitCOVID-19 mortalityLower COVID-19 mortalityApixaban treatmentUnit admissionAspirin treatmentCare unitTreatment AssociatedCandidate treatmentSupport treatmentPatients
2018
Cohort Study of Albumin versus Lactated Ringer's for Postoperative Cardiac Surgery Fluid Resuscitation in the Intensive Care Unit
Fink RJ, Young A, Yanez ND, Hom M, Mai J, Treggiari M, Merkel M. Cohort Study of Albumin versus Lactated Ringer's for Postoperative Cardiac Surgery Fluid Resuscitation in the Intensive Care Unit. Pharmacotherapy The Journal Of Human Pharmacology And Drug Therapy 2018, 38: 1241-1249. PMID: 30403299, DOI: 10.1002/phar.2195.Peer-Reviewed Original ResearchConceptsIntensive care unitPostcardiac surgery patientsCardiovascular intensive care unitFluid resuscitation strategySurgery patientsCare unitCohort studySecondary outcomesAlbumin useResuscitation strategiesPost interventionAfter cohort studyPost-intervention periodPost-intervention time periodsNet cost savingsIntervention time periodFluid resuscitationClinical parametersAlbumin reductionEvidence-based practiceAdmission ordersIntervention periodLactated Ringer'sPatientsEducational intervention
2015
Patient-Level Interventions to Prevent the Acquisition of Resistant Gram-Negative Bacteria in Critically Ill Patients: A Systematic Review
Zaky A, Zeliadt SB, Treggiari MM. Patient-Level Interventions to Prevent the Acquisition of Resistant Gram-Negative Bacteria in Critically Ill Patients: A Systematic Review. Anaesthesia And Intensive Care 2015, 43: 23-33. PMID: 25579286, DOI: 10.1177/0310057x1504300105.Peer-Reviewed Original ResearchConceptsPatient-level interventionsIntensive care unitMDR-GNBCare unitSystematic reviewMultidrug-resistant Gram-negative bacterial infectionsSelective digestive decontaminationComparative interventional studyGram-negative bacterial infectionsInfection control effortsResistant Gram-negative bacteriaRate of infectionPrevention of colonisationDigestive decontaminationInterventional trialsIll patientsInterventional studyAnalysed trialsControl groupBacterial infectionsInfectionInterventionTrialsSignificant reductionScience databases
2014
Variation in Tracheal Reintubations Among Patients Undergoing Cardiac Surgery Across Washington State Hospitals
Khandelwal N, Dale CR, Benkeser DC, Joffe AM, Yanez ND, Treggiari MM. Variation in Tracheal Reintubations Among Patients Undergoing Cardiac Surgery Across Washington State Hospitals. Journal Of Cardiothoracic And Vascular Anesthesia 2014, 29: 551-559. PMID: 25802193, PMCID: PMC4427545, DOI: 10.1053/j.jvca.2014.11.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAirway ExtubationAirway ManagementCardiac Surgical ProceduresCohort StudiesCoronary Artery BypassCritical CareDatabases, FactualFemaleHealth SurveysHumansIntubation, IntratrachealMaleMiddle AgedRetrospective StudiesRisk FactorsSocioeconomic FactorsTreatment FailureTreatment OutcomeWashingtonConceptsIntensive care unitCardiac surgeryWashington State hospitalsNonfederal hospitalsState HospitalAcute care daysGreater hospital volumeOdds of reintubationCoronary artery bypassRetrospective cohort studyPatient-level characteristicsMultivariate logistic regressionSignificant heterogeneityValvular surgeryArtery bypassCohort studyHospital factorsHospital volumePatient characteristicsTracheal reintubationCare unitProcedure characteristicsHospital characteristicsCare daysReintubation
2013
Validity of Exchangeable Solute Balance as a Measure of Blood Volume in Neurologically Injured Adults
Joffe AM, Healey L, Khandelwal N, Hallman MR, Van Cleve W, Treggiari MM. Validity of Exchangeable Solute Balance as a Measure of Blood Volume in Neurologically Injured Adults. Neurocritical Care 2013, 21: 102-107. PMID: 24057812, DOI: 10.1007/s12028-013-9915-1.Peer-Reviewed Original ResearchConceptsBlood volumeFluid balanceNeuroscience intensive care unitBV measurementsExtracellular fluidConsecutive adult patientsLarge academic medical centerIntensive care unitAcademic medical centerBV testResults55 patientsAdult patientsRoutine careCare unitTotal body waterCapillary leakActual blood volumeMedical CenterRobust variance estimationBVA-100MethodsThe UniversityAlbumin injectionNumber of daysPatientsBody water
2010
Current Practices of Triple-H Prophylaxis and Therapy in Patients with Subarachnoid Hemorrhage
Meyer R, Deem S, David Yanez N, Souter M, Lam A, Treggiari MM. Current Practices of Triple-H Prophylaxis and Therapy in Patients with Subarachnoid Hemorrhage. Neurocritical Care 2010, 14: 24-36. PMID: 20838932, DOI: 10.1007/s12028-010-9437-z.Peer-Reviewed Original ResearchConceptsNeurointensive care unitSubarachnoid hemorrhagePercent of respondentsProphylactic hypervolemiaHemodilution therapySymptomatic vasospasmCerebral vasospasmDedicated neurointensive care unitsDiagnostic approachMean arterial pressureCentral venous cathetersSystolic blood pressureEvidence of vasospasmAneurysmal subarachnoid hemorrhageNeurocritical Care SocietyTarget of therapyBackgroundMedical managementLonger ICULack of evidenceVenous cathetersArterial pressureBlood pressureCare unitHalf of respondentsPressure titration
2009
Randomized trial of light versus deep sedation on mental health after critical illness*
Treggiari MM, Romand JA, Yanez ND, Deem SA, Goldberg J, Hudson L, Heidegger CP, Weiss NS. Randomized trial of light versus deep sedation on mental health after critical illness*. Critical Care Medicine 2009, 37: 2527-2534. PMID: 19602975, DOI: 10.1097/ccm.0b013e3181a5689f.Peer-Reviewed Original ResearchConceptsDeep sedation groupIntensive care unit dischargeIntensive care unitPosttraumatic stress disorderPatients' mental healthSedation groupDeep sedationCare unitMechanical ventilationStress disorderMental healthIntensive care unit staySingle tertiary care centerLight sedation groupDuration of ventilationTertiary care centerUnit dischargeOccurrence of anxietyTrials of lightPosttraumatic stress disorder (PTSD) symptomsUnit stayAdult patientsAdverse eventsCritical illnessPrimary outcome
2008
The effect of an intensive care unit staffing model on tidal volume in patients with acute lung injury
Cooke CR, Watkins TR, Kahn JM, Treggiari MM, Caldwell E, Hudson LD, Rubenfeld GD. The effect of an intensive care unit staffing model on tidal volume in patients with acute lung injury. Critical Care 2008, 12: r134. PMID: 18980682, PMCID: PMC2646342, DOI: 10.1186/cc7105.Peer-Reviewed Original ResearchConceptsClosed intensive care unitAcute lung injuryIntensive care unitLung injuryCare unitTidal volumeProspective population-based cohortLow VTOpen intensive care unitIntensivist physician staffingPopulation-based cohortProcess of careHospital mortalityVentilatory practicesImproved mortalityIntensive carePhysician staffingPatient outcomesMean VTPatientsDay threeSecondary analysisPotential patientsHigh VTKing CountyExtending the use of inhaled anesthetics beyond the operating room: a giant snake creeping into the intensive care unit.
Treggiari MM. Extending the use of inhaled anesthetics beyond the operating room: a giant snake creeping into the intensive care unit. Respiratory Care 2008, 53: 1280-2. PMID: 18811986.Peer-Reviewed Original ResearchIntensive insulin therapy and mortality in critically ill patients
Treggiari MM, Karir V, Yanez ND, Weiss NS, Daniel S, Deem SA. Intensive insulin therapy and mortality in critically ill patients. Critical Care 2008, 12: r29. PMID: 18312617, PMCID: PMC2374630, DOI: 10.1186/cc6807.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesCritical CareDose-Response Relationship, DrugFemaleGlycemic IndexHospital MortalityHumansHypoglycemiaHypoglycemic AgentsInsulinIntensive Care UnitsLength of StayMaleMiddle AgedMultiple Organ FailureRandomized Controlled Trials as TopicRegression AnalysisSeverity of Illness IndexTrauma CentersConceptsIntensive care unitHospital mortalityIll patientsSequential Organ Failure Assessment scoreOrgan Failure Assessment scorePost-cardiac surgery patientsLevel 1 trauma centerExcess hospital mortalityAdjusted hospital mortalityOccurrence of hypoglycemiaTight glycemic controlMain study endpointMultivariable regression analysisPeriod IIICU lengthPeriod IIICohort studyInsulin therapySurgery patientsGlycemic controlOrgan dysfunctionStudy endpointCare unitTrauma centerStudy population
2006
Risk factors for reperfusion injury after lung transplantation
Cottini SR, Lerch N, de Perrot M, Treggiari MM, Spiliopoulos A, Nicod L, Ricou B. Risk factors for reperfusion injury after lung transplantation. Intensive Care Medicine 2006, 32: 557-563. PMID: 16520995, DOI: 10.1007/s00134-006-0096-7.Peer-Reviewed Original ResearchConceptsReperfusion injuryIntensive care unitPulmonary hypertensionLung transplantationHigher systolic pulmonary pressureSurgical intensive care unitDonor/recipient pairsSystolic pulmonary hypertensionSystolic pulmonary pressureAdministration of catecholaminesDifficult hemostasisSettingRetrospective studyICU mortalityPerioperative hemostasisPostoperative variablesPulmonary pressurePreoperative valuesCare unitMechanical ventilationUniversity HospitalDonor factorsEarly recognitionRisk factorsRecipient pairsRelative odds
2005
A nationwide survey of intensive care unit discharge practices
Heidegger CP, Treggiari MM, Romand JA, and the Swiss ICU Network. A nationwide survey of intensive care unit discharge practices. Intensive Care Medicine 2005, 31: 1676-1682. PMID: 16249927, DOI: 10.1007/s00134-005-2831-x.Peer-Reviewed Original ResearchConceptsDischarge decisionsDischarge practicesCentral Referral HospitalIntermediate care unitUniversity Teaching HospitalIntensive care medicineIntermediate care facilitiesAdult ICUsClinical determinantsDischarge dispositionReferral hospitalCare unitIntravenous medicationsPatient dischargeUniversity HospitalHospital characteristicsICU teamTeaching hospitalPatient managementSwiss ICUsConclusionsOur dataDischarge guidelinesCare medicineICU structureCare facilities