2014
Regulation of Nasal Airway Homeostasis and Inflammation in Mice by SHP-1 and Th2/Th1 Signaling Pathways
Cho SH, Oh SY, Lane AP, Lee J, Oh MH, Lee S, Zheng T, Zhu Z. Regulation of Nasal Airway Homeostasis and Inflammation in Mice by SHP-1 and Th2/Th1 Signaling Pathways. PLOS ONE 2014, 9: e103685. PMID: 25090641, PMCID: PMC4121172, DOI: 10.1371/journal.pone.0103685.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChemokinesEosinophiliaGelatinHomeostasisInflammationInterferon-gammaMatrix Metalloproteinase 2Matrix Metalloproteinase 9MetaplasiaMice, Inbred C57BLMice, Mutant StrainsMucusNasal Lavage FluidNasal MucosaProtein Tyrosine Phosphatase, Non-Receptor Type 6RhinitisSignal TransductionTh1 CellsTh2 CellsConceptsMatrix metalloproteinasesNasal inflammationAllergic rhinitisTh1 cytokinesInflammatory cellsTh2 cytokinesNasal airwayChronic inflammatory diseaseExpression of cytokinesTh2-skewed inflammationIFN-γ geneMucus metaplasiaTh1 paradigmAirway homeostasisInflammatory mediatorsTh2 lymphocytesImmune homeostasisInflammatory diseasesViable motheaten miceInflammationTransepithelial migrationCytokinesMev miceClearance mechanismsTh2
2011
The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma
Zheng T, Yu J, Oh MH, Zhu Z. The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma. Allergy Asthma And Immunology Research 2011, 3: 67-73. PMID: 21461244, PMCID: PMC3062798, DOI: 10.4168/aair.2011.3.2.67.Peer-Reviewed Original ResearchPathogenesis of ADAtopic dermatitisAtopic marchAllergic rhinitisMechanisms of ADIgE-mediated sensitizationPruritic skin lesionsT helper 1More effective treatmentsAdaptive immune systemEpidermal barrier functionImmunological sequelaeEnvironmental allergensTh2 paradigmBarrier disruptionInflammatory diseasesSkin lesionsEffective treatmentEpithelial barrierImmune systemDisease initiationBarrier functionPrimary defectLongitudinal studyRhinitis