2018
Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models
Leone R, Sun I, Oh M, Sun I, Wen J, Englert J, Powell J. Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models. Cancer Immunology, Immunotherapy 2018, 67: 1271-1284. PMID: 29923026, PMCID: PMC11028354, DOI: 10.1007/s00262-018-2186-0.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine A2 Receptor AntagonistsAnimalsAntigens, CDCD8-Positive T-LymphocytesColonic NeoplasmsFemaleGene Expression Regulation, NeoplasticImmunotherapyLymphocyte Activation Gene 3 ProteinLymphocytes, Tumor-InfiltratingMaleMelanoma, ExperimentalMiceMice, Inbred BALB CMice, Inbred C57BLProgrammed Cell Death 1 ReceptorReceptor, Adenosine A2AReceptors, Antigen, T-CellT-Lymphocytes, RegulatoryTumor Cells, CulturedTumor MicroenvironmentXenograft Model Antitumor AssaysConceptsA2AR blockadePD-1T cellsImmune responseA2A receptorsCD39/CD73 axisTumor immune evasionEffector T cellsLAG-3 expressionRegulatory T cellsT cell persistenceTumor bearing miceAdenosine A2A receptorsMurine cancer modelsCoinhibitory receptorsCheckpoint blockadeCheckpoint therapyRegulatory cellsLymph nodesImmunologic responseImmunotherapy regimensInflammatory milieuPharmacologic blockadeA2AR antagonistAdenosine levels
2013
SHP-1 Regulation of Mast Cell Function in Allergic Inflammation and Anaphylaxis
Zhou L, Oh SY, Zhou Y, Yuan B, Wu F, Oh MH, Wang Y, Takemoto C, Van Rooijen N, Zheng T, Zhu Z. SHP-1 Regulation of Mast Cell Function in Allergic Inflammation and Anaphylaxis. PLOS ONE 2013, 8: e55763. PMID: 23390550, PMCID: PMC3563592, DOI: 10.1371/journal.pone.0055763.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAllergensAnaphylaxisAnimalsBasophilsCell DifferentiationCells, CulturedCytokinesGene ExpressionInflammationInjections, IntravenousLipopolysaccharidesLungMast CellsMiceMice, KnockoutOvalbuminProtein Tyrosine Phosphatase, Non-Receptor Type 6Respiratory HypersensitivitySignal TransductionTh2 CellsConceptsTh2 immune responseAllergic inflammationAirway inflammationMast cell functionImmune responseMast cellsDeficient bone marrow cellsMast cell-deficient miceCell-deficient miceCell functionSevere allergic reactionsWild-type miceSHP-1Bone marrow cellsAirway stimulationAdoptive transferSystemic anaphylaxisAnaphylactic responseClinical symptomsImmunological homeostasisDeficient miceAllergic reactionsType miceAnaphylaxisInflammation
2007
TH2 and TH1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNA
Jeon SG, Oh SY, Park HK, Kim YS, Shim EJ, Lee HS, Oh MH, Bang B, Chun EY, Kim SH, Gho YS, Zhu Z, Kim YY, Kim YK. TH2 and TH1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNA. Journal Of Allergy And Clinical Immunology 2007, 120: 803-812. PMID: 17610940, DOI: 10.1016/j.jaci.2007.05.030.Peer-Reviewed Original ResearchConceptsRespiratory viral infectionsAllergen sensitizationLung inflammationViral infectionAirway sensitizationIL-4Immune responseMouse modelHigh dosesIL-13-deficient miceIFN-gamma-deficient miceT-bet-deficient miceToll-like receptor 3Airway allergen exposureAllergic lung inflammationAdaptive immune responsesToll-like receptorsIL-4 expressionSTAT6-deficient miceNovel mouse modelIFN-gamma expressionAllergen exposurePathophysiologic mechanismsIL-13Deficient miceAirway Exposure Levels of Lipopolysaccharide Determine Type 1 versus Type 2 Experimental Asthma
Kim YK, Oh SY, Jeon SG, Park HW, Lee SY, Chun EY, Bang B, Lee HS, Oh MH, Kim YS, Kim JH, Gho YS, Cho SH, Min KU, Kim YY, Zhu Z. Airway Exposure Levels of Lipopolysaccharide Determine Type 1 versus Type 2 Experimental Asthma. The Journal Of Immunology 2007, 178: 5375-5382. PMID: 17404323, DOI: 10.4049/jimmunol.178.8.5375.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnimalsAsthmaBronchial HyperreactivityFemaleHumansInterferon-gammaInterleukin-12LipopolysaccharidesMaleMiceMice, Inbred BALB CMice, Inbred C57BLMiddle AgedOvalbuminReceptors, Tumor Necrosis FactorRNA, MessengerSignal TransductionSTAT4 Transcription FactorTh1 CellsTh2 CellsTransforming Growth Factor beta1Tumor Necrosis Factor-alphaConceptsHigh-dose LPSLow-dose LPSAsthma phenotypesAdaptive immune responsesImmune responseAirway hyperresponsivenessAllergen sensitizationTNF-alpha receptor-deficient miceType 1IFN-gamma-deficient miceSevere asthma patientsReceptor-deficient miceAllergen-specific IgEExposure levelsIL-12 expressionTNF-alpha expressionIFN-gamma expressionLow LPS levelsNoneosinophilic inflammationAirway inflammationAllergic asthmaNeutrophilic inflammationSevere asthmaAirway exposureAsthma patients