2023
GOT1 regulates CD8+ effector and memory T cell generation
Xu W, Patel C, Zhao L, Sun I, Oh M, Sun I, Helms R, Wen J, Powell J. GOT1 regulates CD8+ effector and memory T cell generation. Cell Reports 2023, 42: 111987. PMID: 36640309, PMCID: PMC9943022, DOI: 10.1016/j.celrep.2022.111987.Peer-Reviewed Original ResearchConceptsIntracellular redox balancePosttranslational regulationHIF proteinsMetabolic reprogrammingRedox balanceΑ-ketoglutarateGOT1T cell activationCell generationGenetic deletionEffector differentiationCritical roleCell activationDifferentiationRegulationProliferationReprogrammingBiosynthesisEffectorsProteinDeletionMechanisticallyCytotoxic functionFunctionPurine
2017
mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages
Oh M, Collins S, Sun I, Tam A, Patel C, Arwood M, Chan-Li Y, Powell J, Horton M. mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages. Cell Reports 2017, 20: 2439-2454. PMID: 28877476, PMCID: PMC5659290, DOI: 10.1016/j.celrep.2017.08.046.Peer-Reviewed Original ResearchConceptsTissue-resident macrophagesMetabolic reprogrammingTissue-specific cuesUnique differentiation programCritical roleDifferentiation programmingPeritoneal resident macrophagesDifferentiation programMTORC2 activationGATA6 expressionPeritoneal macrophagesResident peritoneal macrophagesTissue microenvironmentHomeostatic functionsReprogrammingSelective roleMacrophage generationMacrophage proliferationDifferentiationDependent fashionResident macrophagesMacrophagesM2 macrophagesGATA6Microenvironment
2016
Deletion of mTORC1 Activity in CD4+ T Cells Is Associated with Lung Fibrosis and Increased γδ T Cells
Vigeland C, Collins S, Chan-Li Y, Hughes A, Oh M, Powell J, Horton M. Deletion of mTORC1 Activity in CD4+ T Cells Is Associated with Lung Fibrosis and Increased γδ T Cells. PLOS ONE 2016, 11: e0163288. PMID: 27649073, PMCID: PMC5029914, DOI: 10.1371/journal.pone.0163288.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBleomycinCD4-Positive T-LymphocytesDisease Models, AnimalInterleukin-17MacrophagesMechanistic Target of Rapamycin Complex 1MiceMice, KnockoutMultiprotein ComplexesNeutrophilsPulmonary FibrosisReceptors, Antigen, T-Cell, gamma-deltaSignal TransductionT-Lymphocyte SubsetsTOR Serine-Threonine KinasesConceptsΓδ T cellsTh17 cellsDevelopment of fibrosisT cellsPulmonary fibrosisIL-17AChronic inflammationCytokines IL-17ADevelopment of bleomycinNovel therapeutic targetLung dysfunctionLung neutrophilsProgressive fibrosisLung fibrosisM2 macrophagesTherapeutic targetFibrosisIncurable diseaseInflammationMortalityBleomycinCellsILCritical rolePrior studies