2004
Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity
Fujii N, Boppart M, Dufresne S, Crowley P, Jozsi A, Sakamoto K, Yu H, Aschenbach W, Kim S, Miyazaki H, Rui L, White M, Hirshman M, Goodyear L. Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity. American Journal Of Physiology - Cell Physiology 2004, 287: c200-c208. PMID: 15013949, DOI: 10.1152/ajpcell.00415.2003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDown-RegulationElectroporationEnzyme ActivationGene Transfer TechniquesGlycogen SynthaseHumansInjections, IntramuscularInsulin Receptor Substrate ProteinsMiceMice, KnockoutMitogen-Activated Protein Kinase 8Mitogen-Activated Protein Kinase 9Mitogen-Activated Protein KinasesMuscle ContractionMuscle ProteinsMuscle, SkeletalPhosphoproteinsPhosphorylationSerineTyrosineConceptsGlycogen synthase activityMouse skeletal muscleS6 kinasePhosphorylation stateJNK signalingSynthase activityJNK activityProtein kinase B/AktJNK overexpressionGlycogen synthase kinase-3Skeletal muscleExtracellular signal-regulated kinase 1/2Signal-regulated kinase 1/2P70 S6 kinaseInsulin-stimulated glycogen synthase activitySynthase kinase-3P90 S6 kinaseBasal phosphorylation stateGlycogen synthase activationSitu muscle contractionBiological functionsTerminal kinaseKinase 3JNK activationKinase 1/2
2000
The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307 *
Davis R, Aguirre V, Uchida T, Yenush L, White M. The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307 *. Journal Of Biological Chemistry 2000, 275: 9047-9054. PMID: 10722755, DOI: 10.1074/jbc.275.12.9047.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAnisomycinCHO CellsCricetinaeHumansInsulinInsulin Receptor Substrate ProteinsInsulin ResistanceJNK Mitogen-Activated Protein KinasesMiceMitogen-Activated Protein KinasesMolecular Sequence DataPhosphoproteinsPhosphorylationProtein BindingReceptor, InsulinRecombinant ProteinsSerineSignal TransductionTumor Necrosis Factor-alphaConceptsInsulin-stimulated tyrosine phosphorylationIRS-1Serine 307Tyrosine phosphorylationInsulin receptor substrate-1IRS-1 functionSignal transduction cascadePhosphorylation of Ser307Receptor substrate-1Chinese hamster ovary cellsIRS proteinsActivity of JNKJNK associatesPhosphorylation sitesHamster ovary cellsTransduction cascadeSerine phosphorylationTerminal kinaseSubstrate-1PhosphorylationStrong activatorPromotes Insulin ResistanceJNK phosphorylationOvary cellsJNK