1997
The IRS‐signalling system during insulin and cytokine action
Yenush L, White M. The IRS‐signalling system during insulin and cytokine action. BioEssays 1997, 19: 491-500. PMID: 9204766, DOI: 10.1002/bies.950190608.Peer-Reviewed Original ResearchConceptsIRS-1Grb2-binding proteinGeneral cell growthStructure/function relationshipsAnalysis of miceDrosophila proteinIRS proteinsImportant physiological roleSubstrate recognitionDocking moleculeIntracellular substratesIRS-2Physiological roleCell growthFunction relationshipsProteinDependent diabetes mellitusGrowth factorCytokine actionInsulin actionDiabetes mellitusGlucose metabolismReceptor systemGrowth hormoneIntact animals
1991
The Juxtamembrane Regions of the Epidermal Growth Factor Receptor and gpl85 erbB-2 Determine the Specificity of Signal Transduction
Segatto O, Lonardo F, Wexler D, Fazioli F, Pierce J, Bottaro D, White M, Di Fiore P. The Juxtamembrane Regions of the Epidermal Growth Factor Receptor and gpl85 erbB-2 Determine the Specificity of Signal Transduction. Molecular And Cellular Biology 1991, 11: 3191-3202. DOI: 10.1128/mcb.11.6.3191-3202.1991.Peer-Reviewed Original ResearchEpidermal growth factor receptorSignal transductionSpecificity of substrate recognitionErbB-2Specificity of signal transductionAmino-terminal halfDeletion of residuesMitogenic signaling pathwaysMitogenic signal transductionEGFR kinaseGrowth factor receptorSubstrate recognitionTyrosine kinase domainJuxtamembrane regionKinase domainStructural homologyKinase propertiesFactor receptorMutation analysisSignaling pathwayTyrosine kinaseChimeric moleculesKinaseTyrosineTransduction