2018
Receptor Tyrosine Kinases and the Insulin Signaling System
White M. Receptor Tyrosine Kinases and the Insulin Signaling System. Endocrinology 2018, 121-155. DOI: 10.1007/978-3-319-44675-2_7.Peer-Reviewed Original ResearchProtein tyrosine kinasesTyrosine kinaseExtracellular ligand-binding domainLarge multigene familyRTK family membersInsulin Signaling SystemCell-cell interactionsLigand-binding domainReceptor tyrosine kinasesSystemic nutrient homeostasisPolypeptide growth factorsAspects of metabolismMultigene familyHuman genomeNutrient homeostasisPlasma membraneIntracellular signalsMetabolic regulationSignaling systemInsulin receptorBroader roleHeterologous regulationCell proliferationKinaseGrowth factor
2017
Receptor Tyrosine Kinases and the Insulin Signaling System
White M. Receptor Tyrosine Kinases and the Insulin Signaling System. Endocrinology 2017, 1-34. DOI: 10.1007/978-3-319-27318-1_7-1.Peer-Reviewed Original ResearchProtein tyrosine kinasesTyrosine kinaseExtracellular ligand-binding domainLarge multigene familyRTK family membersInsulin Signaling SystemCell-cell interactionsLigand-binding domainReceptor tyrosine kinasesSystemic nutrient homeostasisPolypeptide growth factorsAspects of metabolismMultigene familyHuman genomeNutrient homeostasisPlasma membraneIntracellular signalsMetabolic regulationSignaling systemInsulin receptorBroader roleHeterologous regulationCell proliferationKinaseGrowth factor
2013
Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis
Sadagurski M, Dong X, Myers M, White M. Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis. Molecular Metabolism 2013, 3: 55-63. PMID: 24567904, PMCID: PMC3929908, DOI: 10.1016/j.molmet.2013.10.004.Peer-Reviewed Original ResearchFed blood glucose levelsBlood glucose levelsLepRb neuronsSevere obesityInsulin resistanceInsulin receptor substrateGlucose levelsLeptin receptorGlucose homeostasisBody weightInsulin/IGF1MiceMetabolic homeostasisEnergy expenditureNeuronsWhole bodyReceptor substrateIRS2Metabolic sensingHomeostasisMetabolic regulationHyperglycemiaLepRbObesityHypothalamus
2006
The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling.
Guo S, Dunn S, White M. The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling. Endocrinology 2006, 20: 3389-99. PMID: 16916938, DOI: 10.1210/me.2006-0092.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedFibroblastsForkhead Box Protein O1Forkhead Transcription FactorsInsulinInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsMiceMice, Mutant StrainsPhosphatidylinositol 3-KinasesPhosphoproteinsProtein KinasesProto-Oncogene Proteins c-aktRecombinant ProteinsSignal TransductionTOR Serine-Threonine KinasesTyrosineConceptsInsulin stimulationWild-type mouse embryo fibroblastsInsulin-receptor substrate IRS1Metastatic mammary tumor cellsProlonged insulin stimulationMouse embryo fibroblastsTranscription factor FOXO1Substrates IRS1FoxO phosphorylationRegulatory circuitsNuclear exclusionWT MEFsTyrosine phosphorylationGene expressionMetabolic regulationEmbryo fibroblastsIRS1 expressionMammary tumor cellsIRS2 expressionCell growthIRS2AktIRS1MEFsPancreatic beta cells