Featured Publications
Elevated circulating follistatin associates with an increased risk of type 2 diabetes
Wu C, Borné Y, Gao R, López Rodriguez M, Roell W, Wilson J, Regmi A, Luan C, Aly D, Peter A, Machann J, Staiger H, Fritsche A, Birkenfeld A, Tao R, Wagner R, Canouil M, Hong M, Schwenk J, Ahlqvist E, Kaikkonen M, Nilsson P, Shore A, Khan F, Natali A, Melander O, Orho-Melander M, Nilsson J, Häring H, Renström E, Wollheim C, Engström G, Weng J, Pearson E, Franks P, White M, Duffin K, Vaag A, Laakso M, Stefan N, Groop L, De Marinis Y. Elevated circulating follistatin associates with an increased risk of type 2 diabetes. Nature Communications 2021, 12: 6486. PMID: 34759311, PMCID: PMC8580990, DOI: 10.1038/s41467-021-26536-w.Peer-Reviewed Original ResearchConceptsAdipose tissue insulin resistanceTissue insulin resistanceType 2 diabetesFollistatin levelsGlucokinase regulatory protein geneFollistatin secretionHazard ratioInsulin resistanceNon-alcoholic fatty liver diseaseAdjusted hazard ratioFatty liver diseaseRisk of T2DFree fatty acid releaseFatty acid releaseIncident T2DLiver diseaseGenome-wide association studiesHuman adipocytesT2DAcid releaseStandard deviation increaseDiabetesSecretionRiskRegulatory protein gene
2016
Mechanism of Insulin Action
White M. Mechanism of Insulin Action. 2016, 114-132. DOI: 10.1002/9781118924853.ch8.Peer-Reviewed Original ResearchInsulin-like signalingGenome-wide association studiesInsulin-like peptidesClassical insulin target tissuesInsulin-like growth factor 2Receptor tyrosine kinasesSimilar receptor tyrosine kinasesEnvironmental signalsHuman genomeInsulin target tissuesGenetic lociPancreatic β-cellsInsulin signalTyrosine kinaseAssociation studiesRelease of nutrientsConflicting signalsGrowth factor 2IGF signalingAnimal growthFactor 1Factor 2Insulin-like growth factor-1Β-cellsGenes