2020
Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance
Sutton A, Gonzalez I, Sadagurski M, Rajala M, Lu C, Allison M, Adams J, Myers M, White M, Olson D. Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance. Scientific Reports 2020, 10: 5546. PMID: 32218485, PMCID: PMC7099088, DOI: 10.1038/s41598-020-62468-z.Peer-Reviewed Original ResearchConceptsEnergy expenditureEnergy expenditure regulationAnti-obesity therapiesFeeding-related behaviorsNormal energy balanceInsulin receptor substrate 4Negative energy balancePVH neuronsHypothalamic circuitryHypothalamic sitesEnergy balance controlFeeding suppressionParaventricular nucleusSatiety responseSubstantial obesityNormal feedingPVHNeuronsViral toolsNeural componentsHindbrain regionsObesityRequisite roleBalance controlEnergy balance
2013
Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis
Sadagurski M, Dong X, Myers M, White M. Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis. Molecular Metabolism 2013, 3: 55-63. PMID: 24567904, PMCID: PMC3929908, DOI: 10.1016/j.molmet.2013.10.004.Peer-Reviewed Original ResearchFed blood glucose levelsBlood glucose levelsLepRb neuronsSevere obesityInsulin resistanceInsulin receptor substrateGlucose levelsLeptin receptorGlucose homeostasisBody weightInsulin/IGF1MiceMetabolic homeostasisEnergy expenditureNeuronsWhole bodyReceptor substrateIRS2Metabolic sensingHomeostasisMetabolic regulationHyperglycemiaLepRbObesityHypothalamus
2009
Human IL6 enhances leptin action in mice
Sadagurski M, Norquay L, Farhang J, D’Aquino K, Copps K, White M. Human IL6 enhances leptin action in mice. Diabetologia 2009, 53: 525-535. PMID: 19902173, PMCID: PMC2815798, DOI: 10.1007/s00125-009-1580-8.Peer-Reviewed Original ResearchConceptsOb/ob miceWild-type miceOb miceHuman IL6Leptin actionDiet-induced obesityHigh-fat dietLower leptin concentrationsHypothalamic signal transducerCentral leptin actionSystemic inflammationTranscription 3 (STAT3) phosphorylationLeptin injectionInflammatory cytokinesInsulin resistanceLeptin concentrationsFood intakePhysical activityGlucose homeostasisAims/Body weightIL6MiceEnergy expenditureObesity