2024
Spectris™ treatment preserves corpus callosum structure in Alzheimer's disease
Da X, Hempel E, Brickman A, Hajós M, Kern R, Cimenser A. Spectris™ treatment preserves corpus callosum structure in Alzheimer's disease. Frontiers In Neurology 2024, 15: 1452930. PMID: 39479005, PMCID: PMC11522122, DOI: 10.3389/fneur.2024.1452930.Peer-Reviewed Original ResearchParallel electrophysiological abnormalities due to COVID‐19 infection and to Alzheimer's disease and related dementia
Jiang Y, Neal J, Sompol P, Yener G, Arakaki X, Norris C, Farina F, Ibanez A, Lopez S, Al‐Ezzi A, Kavcic V, Güntekin B, Babiloni C, Hajós M. Parallel electrophysiological abnormalities due to COVID‐19 infection and to Alzheimer's disease and related dementia. Alzheimer's & Dementia 2024, 20: 7296-7319. PMID: 39206795, PMCID: PMC11485397, DOI: 10.1002/alz.14089.Peer-Reviewed Original ResearchCOVID-19 patientsEEG abnormalitiesNeurophysiological abnormalitiesMild cognitive impairmentCognitive deficitsBrain activityAstrocyte reactivityPredicting long-term outcomesCognitive impairmentLong-term outcomesSlowing of EEGCognitive declineEfficacy of therapeutic interventionsIntrinsic brain activityLong COVIDElectrophysiological brain activityEEG slowingNeurological complicationsEpileptiform activityEEG monitoringEarly stages of neurodegenerative diseasesCognitive decline riskNeurovascular injuryLong COVID-19Acute phaseCognito’s non-invasive medical device demonstrates durable effects on activities of daily living through OVERTURE open-label extension study. (N2.002)
Kern R, Kuang C, Hajos M, Konisky A, Boasso A, Hempel E, Vaughan B, Seshagiri C, Malchano Z, Hendrix S, Saikali K, Massey J, Arjunji R. Cognito’s non-invasive medical device demonstrates durable effects on activities of daily living through OVERTURE open-label extension study. (N2.002). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000205670.Peer-Reviewed Original ResearchSafety, tolerability, and efficacy estimate of evoked gamma oscillation in mild to moderate Alzheimer’s disease
Hajós M, Boasso A, Hempel E, Shpokayte M, Konisky A, Seshagiri C, Fomenko V, Kwan K, Nicodemus-Johnson J, Hendrix S, Vaughan B, Kern R, Megerian J, Malchano Z. Safety, tolerability, and efficacy estimate of evoked gamma oscillation in mild to moderate Alzheimer’s disease. Frontiers In Neurology 2024, 15: 1343588. PMID: 38515445, PMCID: PMC10957179, DOI: 10.3389/fneur.2024.1343588.Peer-Reviewed Original ResearchAssessment of adverse eventsMild to moderate ADGamma oscillationsModerate ADAmyloid-related imaging abnormalitiesAlzheimer's diseaseMild-to-moderate Alzheimer's diseaseSecondary clinical outcome measuresTherapy systemPrimary outcome measureHigher adherence ratesWhole-brain volumeClinical outcome measuresSecondary outcome measuresModerate Alzheimer's diseaseDisease-modifying effectsBaseline MMSE scoreStudy discontinuationExperimental AD modelsWell-toleratedEfficacy outcomesClinical benefitAdverse eventsDaily treatmentClinical criteriaNoninvasive Gamma Sensory Stimulation May Reduce White Matter and Myelin Loss in Alzheimer’s Disease
Da X, Hempel E, Ou Y, Rowe O, Malchano Z, Hajós M, Kern R, Megerian J, Cimenser A. Noninvasive Gamma Sensory Stimulation May Reduce White Matter and Myelin Loss in Alzheimer’s Disease. Journal Of Alzheimer's Disease 2024, 97: 359-372. PMID: 38073386, PMCID: PMC10789351, DOI: 10.3233/jad-230506.Peer-Reviewed Original ResearchConceptsWhite matter atrophyActive treatment participantsMatter atrophyAlzheimer's diseaseMyelin lossTreatment participantsWhite matterNeuronal network functionT2-weighted MRIEarly disease interventionMRI outcomesClinical trialsEntorhinal regionWhite matter structuresHz stimulationMagnetic resonance imaging dataAfferent connectionsInclusion criteriaTherapeutic approachesAtrophySensory stimulationVolume assessmentDisease interventionDiseaseMyelin content
2023
Lobe‐specific changes in white matter volume and myelination following 6‐month 40 Hz gamma sensory stimulation in patients on the Alzheimer’s disease spectrum
Cimenser A, Da X, Hempel E, Malchano Z, Vaughan B, Megerian J, Hajos M. Lobe‐specific changes in white matter volume and myelination following 6‐month 40 Hz gamma sensory stimulation in patients on the Alzheimer’s disease spectrum. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.073143.Peer-Reviewed Original ResearchWhite matter volumeAlzheimer's diseaseWhite matterPlacebo groupTemporal lobeMatter volumeFrontal lobeParietal lobeWhite matter atrophyGray matter changesMRI T1 imagesTreatment group resultsMonth 3Month 6Neurological comorbiditiesT1w/T2w ratioMatter atrophyAD patientsMagnetic resonance imaging dataPathological changesOccipital lobePlacebo participantsMatter changesNeuronal activityTreatment groupsSensory‐Evoked 40Hz Gamma Oscillation: A Feasible and Promising Treatment Option for Alzheimer’s Disease
Hajos M, Boasso A, Cimenser A, Shpokayte M, Hempel E, Da X, Seshagiri C, Megerian J, Vaughan B, Malchano Z. Sensory‐Evoked 40Hz Gamma Oscillation: A Feasible and Promising Treatment Option for Alzheimer’s Disease. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.072957.Peer-Reviewed Original ResearchClinical trialsAlzheimer's diseaseActive armPotential novel therapeutic interventionsSensory stimulationOccipital cortical thicknessAmyloid plaque loadAbnormal neuronal activityPivotal clinical trialsStimulation systemPromising treatment optionDifferent therapeutic approachesNovel therapeutic interventionsMinimal side effectsQuantitative MRI analysisNeuronal network oscillationsDaily therapyPlaque loadADCS-ADLBrain atrophyClinical presentationTreatment armsClinical benefitClinical efficacyAD pathologyDecay in Entorhinal White Matter/Gray Matter contrast in Alzheimer’s Disease Patients is reduced by 40Hz sensory stimulation
Da X, Hempel E, Malchano Z, Vaughan B, Megerian J, Hajos M, Cimenser A. Decay in Entorhinal White Matter/Gray Matter contrast in Alzheimer’s Disease Patients is reduced by 40Hz sensory stimulation. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.077337.Peer-Reviewed Original ResearchMagnetic resonance imagingEntorhinal regionAlzheimer's diseaseWhite matterPlacebo groupDisease patientsMRI measuresTreatment groupsPlacebo-controlled feasibility studyPhase I/IISensory stimulationMonth 6 visitMonths of treatmentStructural magnetic resonance imagingAlzheimer's disease patientsSignal intensityT1 magnetic resonance imagingLinear mixed-effects modelingMonth 3WM atrophyMyelin lossAD severityWM/GM contrastMixed-effects modelingAD patientsA Randomized, Double‐blind, Sham‐controlled, Adaptive‐Design Pivotal Trial of Sensory Stimulation in Subjects with Alzheimer’s Disease
Boasso A, Houser C, Hajos M, Newberger J, Seshagiri C, Leach J, Konisky A, Galley A, Hempel E, Dickson S, Hendrix S, Malchano Z, Megerian J. A Randomized, Double‐blind, Sham‐controlled, Adaptive‐Design Pivotal Trial of Sensory Stimulation in Subjects with Alzheimer’s Disease. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.080670.Peer-Reviewed Original ResearchMini-Mental State ExamClinical Dementia Rating ScaleZarit Burden IndexPivotal trialsSensory stimulationAlzheimer's Disease Cooperative Study-ActivitiesConcurrent medication useOccipital cortical thicknessKey secondary outcomesProspective clinical trialsPrimary outcome measureSelf-administered therapyClinical laboratory assessmentsClinical efficacy assessmentBrain structural changesDaily living testDementia Rating ScaleSubgroup of subjectsMental State ExamAlzheimer's disease symptomsHOPE trialSecondary outcomesAdverse eventsMedication useADCS-ADLEPH230 Estimating Risk of Disease Progression from Mild Cognitive Impairment (MCI) to Alzheimer’s Disease (AD) Using Administrative Claims
Gregory S, Abdelhadi J, Conroy B, Yoon L, Irwin D, Malchano Z, Hajos M, Megerian J, Grundman M, Crosland E. EPH230 Estimating Risk of Disease Progression from Mild Cognitive Impairment (MCI) to Alzheimer’s Disease (AD) Using Administrative Claims. Value In Health 2023, 26: s204-s205. DOI: 10.1016/j.jval.2023.03.2576.Peer-Reviewed Original Research
2022
Coherent Activity in EEG Response to Gamma Sensory Stimulation Predicts Positive Outcome in Cognitive and Functional Abilities, and Brain Atrophy in Subjects with Alzheimer’s Disease (P4-6.004)
Cimenser A, Mrozak H, Da X, Travers T, Hempel E, Seshagiri C, Boasso A, Vaughan B, Megerian J, Malchano Z, Hajos M. Coherent Activity in EEG Response to Gamma Sensory Stimulation Predicts Positive Outcome in Cognitive and Functional Abilities, and Brain Atrophy in Subjects with Alzheimer’s Disease (P4-6.004). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.1799.Peer-Reviewed Original ResearchFeasibility, Safety, and Efficacy of Gamma Sensory Stimulation as a Novel Therapeutic Intervention for Alzheimer’s Disease (N1.001)
Megerian J, Hajos M, Hempel E, Cimenser A, Boasso A, Cotter C, Williams M, Kwan K, Nicodemus-Johnson J, Hendrix S, Vaughan B, Malchano Z. Feasibility, Safety, and Efficacy of Gamma Sensory Stimulation as a Novel Therapeutic Intervention for Alzheimer’s Disease (N1.001). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.1936.Peer-Reviewed Original Research
2014
Receptor-channel research at the interface between academia and pharma
Hajos M. Receptor-channel research at the interface between academia and pharma. The Biomedical & Life Sciences Collection 2014, 2014: e1003682. DOI: 10.69645/qfdp1005.Peer-Reviewed Original Research
2012
Age-dependent disruption in hippocampal theta oscillation in amyloid-β overproducing transgenic mice
Scott L, Feng J, Kiss T, Needle E, Atchison K, Kawabe TT, Milici AJ, Hajós-Korcsok É, Riddell D, Hajós M. Age-dependent disruption in hippocampal theta oscillation in amyloid-β overproducing transgenic mice. Neurobiology Of Aging 2012, 33: 1481.e13-1481.e23. PMID: 22227005, DOI: 10.1016/j.neurobiolaging.2011.12.010.Peer-Reviewed Original ResearchConceptsAPP/PS1 miceLong-term potentiationHippocampal theta oscillationsPS1 micePlaque loadPopulation spikesTransgenic miceDisease pathologyAPPswe/PS1dE9Theta oscillationsAge-dependent disruptionVivo electrophysiological methodsAlzheimer's disease pathologyWild-type miceAge-dependent decreaseMonths of ageHippocampal network oscillationsBrain amyloidUrethane anesthesiaBrainstem stimulationDentate gyrusFunctional deficitsInsoluble AβType miceEarly Aβ
2006
Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship
Wishka D, Walker D, Yates K, Reitz S, Jia S, Myers J, Olson K, Jacobsen E, Wolfe M, Groppi V, Hanchar A, Thornburgh B, Cortes-Burgos L, Wong E, Staton B, Raub T, Higdon N, Wall T, Hurst R, Walters R, Hoffmann W, Hajos M, Franklin S, Carey G, Gold L, Cook K, Sands S, Zhao S, Soglia J, Kalgutkar A, Arneric S, Rogers B. Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship. Journal Of Medicinal Chemistry 2006, 49: 4425-4436. PMID: 16821801, DOI: 10.1021/jm0602413.Peer-Reviewed Original ResearchMeSH KeywordsAlpha7 Nicotinic Acetylcholine ReceptorAnimalsBiological AvailabilityBrainBridged Bicyclo Compounds, HeterocyclicCognition DisordersDrug StabilityEther-A-Go-Go Potassium ChannelsEvoked Potentials, AuditoryHumansIn Vitro TechniquesLearningMaleMemoryMicrosomes, LiverNeuronsNicotinic AgonistsNootropic AgentsPatch-Clamp TechniquesQuinuclidinesRadioligand AssayRatsRats, Sprague-DawleyReceptors, NicotinicRecognition, PsychologySchizophreniaStereoisomerismStructure-Activity RelationshipConceptsTreatment of cognitive deficitsPotential treatment of cognitive deficitsExcellent in vitro profileStructure-activity relationshipCognitive deficitsAlpha7 neuronal nicotinic acetylcholine receptorNicotinic acetylcholine receptorsCompound 14Novel object recognitionStructure-activityAuditory sensory gatingAssess cognitive performanceNeuronal nicotinic acetylcholine receptorsAlpha7 nAChR agonistAcetylcholine receptorsSensory gatingCognitive performanceNAChR agonistsPotential treatmentCompoundsAlpha7 nAChRsObject recognitionHigh oral bioavailabilitySchizophreniaBrain penetration