2023
Sensory‐Evoked 40Hz Gamma Oscillation: A Feasible and Promising Treatment Option for Alzheimer’s Disease
Hajos M, Boasso A, Cimenser A, Shpokayte M, Hempel E, Da X, Seshagiri C, Megerian J, Vaughan B, Malchano Z. Sensory‐Evoked 40Hz Gamma Oscillation: A Feasible and Promising Treatment Option for Alzheimer’s Disease. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.072957.Peer-Reviewed Original ResearchClinical trialsAlzheimer's diseaseActive armPotential novel therapeutic interventionsSensory stimulationOccipital cortical thicknessAmyloid plaque loadAbnormal neuronal activityPivotal clinical trialsStimulation systemPromising treatment optionDifferent therapeutic approachesNovel therapeutic interventionsMinimal side effectsQuantitative MRI analysisNeuronal network oscillationsDaily therapyPlaque loadADCS-ADLBrain atrophyClinical presentationTreatment armsClinical benefitClinical efficacyAD pathology
2012
Age-dependent disruption in hippocampal theta oscillation in amyloid-β overproducing transgenic mice
Scott L, Feng J, Kiss T, Needle E, Atchison K, Kawabe TT, Milici AJ, Hajós-Korcsok É, Riddell D, Hajós M. Age-dependent disruption in hippocampal theta oscillation in amyloid-β overproducing transgenic mice. Neurobiology Of Aging 2012, 33: 1481.e13-1481.e23. PMID: 22227005, DOI: 10.1016/j.neurobiolaging.2011.12.010.Peer-Reviewed Original ResearchConceptsAPP/PS1 miceLong-term potentiationHippocampal theta oscillationsPS1 micePlaque loadPopulation spikesTransgenic miceDisease pathologyAPPswe/PS1dE9Theta oscillationsAge-dependent disruptionVivo electrophysiological methodsAlzheimer's disease pathologyWild-type miceAge-dependent decreaseMonths of ageHippocampal network oscillationsBrain amyloidUrethane anesthesiaBrainstem stimulationDentate gyrusFunctional deficitsInsoluble AβType miceEarly Aβ