Age-dependent disruption in hippocampal theta oscillation in amyloid-β overproducing transgenic mice
Scott L, Feng J, Kiss T, Needle E, Atchison K, Kawabe TT, Milici AJ, Hajós-Korcsok É, Riddell D, Hajós M. Age-dependent disruption in hippocampal theta oscillation in amyloid-β overproducing transgenic mice. Neurobiology Of Aging 2012, 33: 1481.e13-1481.e23. PMID: 22227005, DOI: 10.1016/j.neurobiolaging.2011.12.010.Peer-Reviewed Original ResearchConceptsAPP/PS1 miceLong-term potentiationHippocampal theta oscillationsPS1 micePlaque loadPopulation spikesTransgenic miceDisease pathologyAPPswe/PS1dE9Theta oscillationsAge-dependent disruptionVivo electrophysiological methodsAlzheimer's disease pathologyWild-type miceAge-dependent decreaseMonths of ageHippocampal network oscillationsBrain amyloidUrethane anesthesiaBrainstem stimulationDentate gyrusFunctional deficitsInsoluble AβType miceEarly Aβ