2019
Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples
Hoogman M, Muetzel R, Guimaraes J, Shumskaya E, Mennes M, Zwiers M, Jahanshad N, Sudre G, Wolfers T, Earl E, Soliva Vila J, Vives-Gilabert Y, Khadka S, Novotny S, Hartman C, Heslenfeld D, Schweren L, Ambrosino S, Oranje B, de Zeeuw P, Chaim-Avancini T, Rosa P, Zanetti M, Malpas C, Kohls G, von Polier G, Seitz J, Biederman J, Doyle A, Dale A, van Erp T, Epstein J, Jernigan T, Baur-Streubel R, Ziegler G, Zierhut K, Schrantee A, Høvik M, Lundervold A, Kelly C, McCarthy H, Skokauskas N, O’Gorman Tuura R, Calvo A, Lera-Miguel S, Nicolau R, Chantiluke K, Christakou A, Vance A, Cercignani M, Gabel M, Asherson P, Baumeister S, Brandeis D, Hohmann S, Bramati I, Tovar-Moll F, Fallgatter A, Kardatzki B, Schwarz L, Anikin A, Baranov A, Gogberashvili T, Kapilushniy D, Solovieva A, El Marroun H, White T, Karkashadze G, Namazova-Baranova L, Ethofer T, Mattos P, Banaschewski T, Coghill D, Plessen K, Kuntsi J, Mehta M, Paloyelis Y, Harrison N, Bellgrove M, Silk T, Cubillo A, Rubia K, Lazaro L, Brem S, Walitza S, Frodl T, Zentis M, Castellanos F, Yoncheva Y, Haavik J, Reneman L, Conzelmann A, Lesch K, Pauli P, Reif A, Tamm L, Konrad K, Oberwelland Weiss E, Busatto G, Louza M, Durston S, Hoekstra P, Oosterlaan J, Stevens M, Ramos-Quiroga J, Vilarroya O, Fair D, Nigg J, Thompson P, Buitelaar J, Faraone S, Shaw P, Tiemeier H, Bralten J, Franke B. Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples. American Journal Of Psychiatry 2019, 176: 531-542. PMID: 31014101, PMCID: PMC6879185, DOI: 10.1176/appi.ajp.2019.18091033.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderCortical measuresDeficit hyperactivity disorderChild Behavior ChecklistAdult groupAttention ScaleADHD symptomsAttention problemsCortical thicknessFusiform gyrusHyperactivity disorderADHD diagnosisCortical surface areaLifespan trajectoriesBehavior ChecklistFamilial effectsFuture longitudinal studiesTemporal regionsNeuroimage studiesBrain regionsLarge significant effectLow surface area valuesLongitudinal studyAdolescentsFrontal cortex
2013
Diffusion Tensor Imaging White Matter Endophenotypes in Patients With Schizophrenia or Psychotic Bipolar Disorder and Their Relatives
Skudlarski P, Schretlen DJ, Thaker GK, Stevens MC, Keshavan MS, Sweeney JA, Tamminga CA, Clementz BA, O’Neil K, Pearlson GD. Diffusion Tensor Imaging White Matter Endophenotypes in Patients With Schizophrenia or Psychotic Bipolar Disorder and Their Relatives. American Journal Of Psychiatry 2013, 170: 886-898. PMID: 23771210, DOI: 10.1176/appi.ajp.2013.12111448.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnisotropyBipolar DisorderBrainDiffusion Tensor ImagingDominance, CerebralEndophenotypesGenetic Predisposition to DiseaseHumansImage Interpretation, Computer-AssistedLeukoencephalopathiesNerve NetPhenotypePsychiatric Status Rating ScalesReference ValuesSchizophreniaSchizophrenic PsychologyStatistics as TopicConceptsPsychotic bipolar disorderBipolar disorderWhite matter integrityFractional anisotropyComparison subjectsFractional anisotropy decreasesFirst-degree relativesHealthy comparison subjectsLower white matter integrityDiffusion tensorMultiple white matter regionsLower fractional anisotropyWhite matter regionsBipolar-Schizophrenia NetworkHealthy subjectsBipolar relativesProband groupsYoung subjectsBrain regionsDisease specificityFractional anisotropy measuresUnaffected relativesMatter regionsBrain connectivitySchizophreniaOptimal outcome in individuals with a history of autism
Fein D, Barton M, Eigsti I, Kelley E, Naigles L, Schultz RT, Stevens M, Helt M, Orinstein A, Rosenthal M, Troyb E, Tyson K. Optimal outcome in individuals with a history of autism. Journal Of Child Psychology And Psychiatry 2013, 54: 195-205. PMID: 23320807, PMCID: PMC3547539, DOI: 10.1111/jcpp.12037.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSymptoms of ASDSpectrum disorderSocial interactionFace recognitionHistory of autismMore subtle aspectsNonverbal IQAutism symptomsOutcomes individualsTypical developmentLanguage subscaleHFA groupOO individualsRepetitive behaviorsGroup mean scoresCommunication impairmentsStandardized measuresSocial domainsPossible deficitsMinority of individualsMean scoreAutismSevere difficultiesSubtle aspects
2012
Examining the effect of psychopathic traits on gray matter volume in a community substance abuse sample
Cope LM, Shane MS, Segall JM, Nyalakanti PK, Stevens MC, Pearlson GD, Calhoun VD, Kiehl KA. Examining the effect of psychopathic traits on gray matter volume in a community substance abuse sample. Psychiatry Research 2012, 204: 91-100. PMID: 23217577, PMCID: PMC3536442, DOI: 10.1016/j.pscychresns.2012.10.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntisocial Personality DisorderBrainCognition DisordersFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNerve Fibers, MyelinatedNeuropsychological TestsPersonality InventoryPsychiatric Status Rating ScalesRegression AnalysisResidence CharacteristicsSubstance-Related DisordersConceptsGray matter volumeMatter volumeOrbital frontal cortexMagnetic resonance imagingRight hippocampusFrontal cortexBilateral orbital frontal cortexRight anterior cingulateGray matter reductionsGray matter increasesStructural imaging studiesLimbic regionsBrain abnormalitiesRight insulaParalimbic regionsAnterior cingulateLifetime drugSubstance abuse sampleResonance imagingImaging studiesAlcohol useExploratory regression analysisRegression analysisLimbicMatter reduction
2011
Cortical Thickness and Folding Deficits in Conduct-Disordered Adolescents
Hyatt CJ, Haney-Caron E, Stevens MC. Cortical Thickness and Folding Deficits in Conduct-Disordered Adolescents. Biological Psychiatry 2011, 72: 207-214. PMID: 22209639, PMCID: PMC3367056, DOI: 10.1016/j.biopsych.2011.11.017.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge of OnsetAttention Deficit Disorder with HyperactivityCerebral CortexChildConduct DisorderFemaleFunctional LateralityHumansImage Processing, Computer-AssistedLinear ModelsMagnetic Resonance ImagingMaleNeuropsychological TestsPrefrontal CortexPsychiatric Status Rating ScalesPsychomotor PerformanceSoftwareConceptsCortical thicknessParietal lobeBrain regionsControl subjectsParacentral lobuleConduct disorderThinner cortexCD participantsTemporal lobe structural abnormalitiesPure conduct disorderLocal gyrification indexBrain structure imagesAnterior brain regionsDifferent brain regionsSurface-based morphometryPosterior brain regionsTemporoparietal junctionBrain abnormalitiesGyrification indexTemporal lobeAnterior cingulateFrontal lobeDorsomedial prefrontalStructural abnormalitiesOrbitofrontal cortex
2010
Genetic Associations of Brain Structural Networks in Schizophrenia: A Preliminary Study
Jagannathan K, Calhoun VD, Gelernter J, Stevens MC, Liu J, Bolognani F, Windemuth A, Ruaño G, Assaf M, Pearlson GD. Genetic Associations of Brain Structural Networks in Schizophrenia: A Preliminary Study. Biological Psychiatry 2010, 68: 657-666. PMID: 20691427, PMCID: PMC2990476, DOI: 10.1016/j.biopsych.2010.06.002.Peer-Reviewed Original ResearchConceptsSpecific structural brain abnormalitiesMagnetic resonance imaging (MRI) scansSmall sample sizeHealthy control subjectsStructural brain abnormalitiesStructural magnetic resonance imaging (MRI) scansGray matter deficitsResonance imaging scansCortical gray matterNormal central nervous system developmentRisk genesCentral nervous system developmentBrain structural networksControl subjectsImaging scansBrain abnormalitiesNervous system developmentIllness markersSchizophrenia pathophysiologySchizophrenia risk genesGenetic componentTemporal lobeBrain areasEuropean-American subjectsSchizophrenia patientsBrain Connectivity Is Not Only Lower but Different in Schizophrenia: A Combined Anatomical and Functional Approach
Skudlarski P, Jagannathan K, Anderson K, Stevens MC, Calhoun VD, Skudlarska BA, Pearlson G. Brain Connectivity Is Not Only Lower but Different in Schizophrenia: A Combined Anatomical and Functional Approach. Biological Psychiatry 2010, 68: 61-69. PMID: 20497901, PMCID: PMC2900394, DOI: 10.1016/j.biopsych.2010.03.035.Peer-Reviewed Original ResearchConceptsBrain connectivityFunctional connectivitySchizophrenia patientsAnatomical connectivityState functional magnetic resonance imagingFunctional connectivity alterationsHealthy control subjectsClinical symptom severityGroup differencesAnatomical connectivity mapsFunctional magnetic resonance imagingMagnetic resonance imagingPosterior cingulate cortexGlobal connectivity analysisClinical symptomsWhite matter anatomyControl subjectsConnectivity alterationsCingulate cortexPatientsResonance imagingBrain regionsSymptom severityDMN componentsTask-positive network
2007
An fMRI Auditory Oddball Study of Combined-Subtype Attention Deficit Hyperactivity Disorder
Stevens MC, Pearlson GD, Kiehl KA. An fMRI Auditory Oddball Study of Combined-Subtype Attention Deficit Hyperactivity Disorder. American Journal Of Psychiatry 2007, 164: 1737-1749. PMID: 17974940, DOI: 10.1176/appi.ajp.2007.06050876.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAdolescentAdolescent BehaviorAttentionAttention Deficit Disorder with HyperactivityAuditory PerceptionBrainBrain MappingCerebral CortexChildCognition DisordersDiagnostic and Statistical Manual of Mental DisordersEvoked PotentialsHemodynamicsHumansMagnetic Resonance ImagingMaleMemory DisordersOrientationOxygenPsychiatric Status Rating ScalesPsychomotor PerformanceConceptsAttention deficit hyperactivity disorderEvent-related potentialsFunctional magnetic resonance imagingDeficit hyperactivity disorderBrain regionsHyperactivity disorderHemodynamic activityThree-stimulus auditory oddball taskP3 event-related potentialEvent-related fMRI dataProcessing of targetsAbnormal hemodynamic activityWorking Memory DeficitsSlower task performanceAuditory oddball taskNovel environmental stimuliCortical brain regionsAttentional orientingOrient attentionADHD participantsCognitive processesCognitive representationsOddball studiesNeurobiological theoriesOddball stimuli
2000
Subgroups of Children With Autism by Cluster Analysis: A Longitudinal Examination
STEVENS M, FEIN D, DUNN M, ALLEN D, WATERHOUSE L, FEINSTEIN C, RAPIN I. Subgroups of Children With Autism by Cluster Analysis: A Longitudinal Examination. Journal Of The American Academy Of Child & Adolescent Psychiatry 2000, 39: 346-352. PMID: 10714055, DOI: 10.1097/00004583-200003000-00017.Peer-Reviewed Original ResearchMeSH KeywordsAutistic DisorderChildChild, PreschoolCluster AnalysisFemaleFollow-Up StudiesHumansIntelligenceLongitudinal StudiesMalePsychiatric Status Rating ScalesPsychometricsReproducibility of ResultsConceptsPreschool ageSevere language impairmentSubgroup of childrenSchool-aged childrenNonverbal abilityCognitive functioningLanguage impairmentAutistic symptomsHigher IQLongitudinal examinationSocial abnormalitiesSame childrenDifferential outcomesSubgroup membershipBehavioral scoresFunctioningAutismChildrenIQCluster analysisHigh groupRelationshipImpairmentDifferent levelsLanguage