2001
Intracoronary administration of recombinant human vascular endothelial growth factor to patients with coronary artery disease
Henry T, Rocha-Singh K, Isner J, Kereiakes D, Giordano F, Simons M, Losordo D, Hendel R, Bonow R, Eppler S, Zioncheck T, Holmgren E, McCluskey E. Intracoronary administration of recombinant human vascular endothelial growth factor to patients with coronary artery disease. American Heart Journal 2001, 142: 872-880. PMID: 11685177, DOI: 10.1067/mhj.2001.118471.Peer-Reviewed Original ResearchConceptsRecombinant human vascular endothelial growth factorVascular endothelial growth factorMyocardial perfusion imagingEndothelial growth factorHuman vascular endothelial growth factorPerfusion imagingTherapeutic angiogenesisRadionuclide myocardial perfusion imagingGrowth factorMinimal hemodynamic changesSequential intracoronary infusionsCoronary artery bypassStable exertional anginaDose-escalation trialPercutaneous coronary interventionCoronary artery diseaseReversible perfusion defectsSevere myocardial ischemiaFuture clinical trialsStress myocardial perfusion studyExertional anginaMyocardial perfusion studiesSurgical revascularizationArtery bypassEscalation trialTherapeutic coronary angiogenesis: a fronte praecipitium a tergo lupi? *
Simons M. Therapeutic coronary angiogenesis: a fronte praecipitium a tergo lupi? *. AJP Heart And Circulatory Physiology 2001, 280: h1923-h1927. PMID: 11299191, DOI: 10.1152/ajpheart.2001.280.5.h1923.Peer-Reviewed Original ResearchExpression of vascular endothelial growth factor and its receptors is increased, but microvascular relaxation is impaired in patients after acute myocardial ischemia
Xu X, Li J, Simons M, Li J, Laham R, Sellke F. Expression of vascular endothelial growth factor and its receptors is increased, but microvascular relaxation is impaired in patients after acute myocardial ischemia. Journal Of Thoracic And Cardiovascular Surgery 2001, 121: 735-742. PMID: 11279416, DOI: 10.1067/mtc.2001.112340.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseBiomarkersBlotting, WesternCoronary Artery BypassCoronary CirculationCoronary VesselsDNA ProbesEndothelial Growth FactorsEnzyme InhibitorsFemaleGene ExpressionHeart AtriaHumansLymphokinesMaleMiddle AgedMyocardial IschemiaNitroarginineNitroprussidePrognosisProtein IsoformsReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 1Receptors, Fibroblast Growth FactorReceptors, Growth FactorReceptors, MitogenReceptors, Vascular Endothelial Growth FactorReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSubstance PVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsVasodilationVasodilator AgentsConceptsVascular endothelial growth factorEndothelial growth factorAcute myocardial ischemiaGrowth factor receptor 1Vascular endothelial growth factor receptor 1Vascular endothelial growth factor receptorFactor receptor 1Endothelial growth factor receptorMyocardial ischemiaGrowth factorReceptor 1Growth factor receptorMicrovascular relaxationFactor receptorGrowth factor receptor 2Protein expressionCoronary bypass operationsEndothelial growth factor receptor 2Vascular endothelial growth factor receptor 2Rat myocardial infarction modelFactor receptor 2Human atrial tissueVascular endothelial growthMyocardial infarction modelMessenger RNA levelsEfficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia
Sato K, Wu T, Laham R, Johnson R, Douglas P, Li J, Sellke F, Bunting S, Simons M, Post M. Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia. Journal Of The American College Of Cardiology 2001, 37: 616-623. PMID: 11216988, DOI: 10.1016/s0735-1097(00)01144-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCoronary CirculationDose-Response Relationship, DrugEndothelial Growth FactorsEndothelium, VascularInfusions, Intra-ArterialInfusions, IntravenousLymphokinesMaleMicrocirculationMyocardial ContractionMyocardial IschemiaSwineVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsChronic myocardial ischemiaMyocardial ischemiaL-NAMEIntracoronary groupBlood flowNitro-L-arginine methyl ester hydrochlorideNitric oxide synthase inhibitionEndothelial growth factor treatmentLeft circumflex coronary arteryDose-limiting hypotensionOxide synthase inhibitionCircumflex coronary arteryVascular endothelial growth factor treatmentMyocardial blood flowRegional myocardial functionGrowth factor treatmentVEGF-induced angiogenesisIntravenous groupConcomitant administrationMicrovascular functionIntracoronary infusionCollateral indexDifferent regimensCoronary arteryIntravenous infusion
2000
Efficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemia
Sato K, Laham R, Pearlman J, Novicki D, Sellke F, Simons M, Post M. Efficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemia. The Annals Of Thoracic Surgery 2000, 70: 2113-2118. PMID: 11156130, DOI: 10.1016/s0003-4975(00)02018-x.Peer-Reviewed Original ResearchConceptsChronic myocardial ischemiaRegional blood flowIschemic myocardiumFGF-2Myocardial ischemiaBlood flowPig modelML/min/Perfusion magnetic resonance imagingSingle intravenous infusionGrowth factor administrationRegional wall motionMagnetic resonance imagingAngiographic collateralsIntracoronary treatmentEjection fractionIntracoronary infusionIntravenous infusionIschemic areaFactor administrationMyocardial functionColored microspheresMyocardial perfusionResonance imagingTherapeutic angiogenesisEffect of Intracoronary Recombinant Human Vascular Endothelial Growth Factor on Myocardial Perfusion
Hendel R, Henry T, Rocha-Singh K, Isner J, Kereiakes D, Giordano F, Simons M, Bonow R. Effect of Intracoronary Recombinant Human Vascular Endothelial Growth Factor on Myocardial Perfusion. Circulation 2000, 101: 118-121. PMID: 10637195, DOI: 10.1161/01.cir.101.2.118.Peer-Reviewed Original ResearchMeSH KeywordsCardiotonic AgentsCoronary CirculationCoronary DiseaseCoronary VesselsDipyridamoleDobutamineDose-Response Relationship, DrugDouble-Blind MethodEndothelial Growth FactorsExercise TestHumansInjections, Intra-ArterialLymphokinesRecombinant ProteinsTomography, Emission-Computed, Single-PhotonVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsVasodilator AgentsConceptsRecombinant human vascular endothelial growth factorSingle-photon emission CTVascular endothelial growth factorEndothelial growth factorMyocardial perfusionStress scoresHuman vascular endothelial growth factorGrowth factorPerfusion single-photon emission CTDose-dependent effectPhoton emission CTMyocardial perfusion single photon emission CTCoronary revascularizationRest scorePhase 1 dataAnimal modelsPatientsEmission CTLow dosesTherapeutic angiogenesisVisual findingsPerfusionStatistical significanceClinical applicationScores
1999
Therapeutic myocardial angiogenesis using percutaneous intrapericardial drug delivery
Laham R, Simons M, Hung D. Therapeutic myocardial angiogenesis using percutaneous intrapericardial drug delivery. Clinical Cardiology 1999, 22: 6-9. PMID: 9929761, PMCID: PMC6655779, DOI: 10.1002/clc.4960221305.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCoronary CirculationCoronary VesselsDisease Models, AnimalEndothelial Growth FactorsFibroblast Growth Factor 1Fibroblast Growth Factor 2InjectionsLymphokinesMyocardial IschemiaNeovascularization, PhysiologicPericardiumReproducibility of ResultsSafetyVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsAngiographic methods to assess human coronary angiogenesis
Gibson C, Ryan K, Sparano A, Moynihan J, Rizzo M, Kelley M, Marble S, Laham R, Simons M, McClusky T, Dodge J. Angiographic methods to assess human coronary angiogenesis. American Heart Journal 1999, 137: 169-179. PMID: 9878950, DOI: 10.1016/s0002-8703(99)70473-4.Peer-Reviewed Original Research
1998
Therapeutic Angiogenesis With Basic Fibroblast Growth Factor: Technique and Early Results
Sellke F, Laham R, Edelman E, Pearlman J, Simons M. Therapeutic Angiogenesis With Basic Fibroblast Growth Factor: Technique and Early Results. The Annals Of Thoracic Surgery 1998, 65: 1540-1544. PMID: 9647055, DOI: 10.1016/s0003-4975(98)00340-3.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlginatesAngina PectorisCollateral CirculationCoronary Artery BypassCoronary Artery DiseaseCoronary CirculationCoronary VesselsCreatinineDelayed-Action PreparationsDrug CarriersFeasibility StudiesFemaleFibroblast Growth Factor 2Follow-Up StudiesGlucuronic AcidHeparinHexuronic AcidsHumansMaleMiddle AgedMyocardial ContractionMyocardial InfarctionNeovascularization, PhysiologicPericardiumSafetyStroke VolumeSurvival RateConceptsBasic fibroblast growth factorCoronary artery bypassFibroblast growth factorArtery bypassGrowth factorTherapeutic angiogenesisConventional coronary artery bypassBasic fibroblast growth factor (bFGF) administrationSlow-release devicesStress perfusion scansPerioperative myocardial infarctionSerum creatinine levelsDifficult clinical problemFixed perfusion defectsLong-term resultsMyocardial contractile functionGrowth factor administrationOperative mortalityPatent arteriesMyocardial revascularizationCreatinine levelsEjection fractionClinical efficacyHepatic toxicityPerfusion scanComparison of VEGF Delivery Techniques on Collateral-Dependent Microvascular Reactivity
Sellke F, Tofukuji M, Laham R, Li J, Hariawala M, Bunting S, Simons M. Comparison of VEGF Delivery Techniques on Collateral-Dependent Microvascular Reactivity. Microvascular Research 1998, 55: 175-178. PMID: 9521892, DOI: 10.1006/mvre.1997.2066.Peer-Reviewed Original ResearchAdenosine DiphosphateAngina, UnstableAnimalsCollateral CirculationCoronary CirculationDrug Delivery SystemsEndothelial Growth FactorsFemaleLymphokinesMaleMicrocirculationMyocardial IschemiaNeovascularization, PhysiologicSwineVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsVasodilationAngiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia
Lopez J, Edelman E, Stamler A, Hibberd M, Prasad P, Thomas K, Disalvo J, Caputo R, Carrozza J, Douglas P, Sellke F, Simons M. Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia. American Journal Of Physiology 1998, 274: h930-h936. PMID: 9530206, DOI: 10.1152/ajpheart.1998.274.3.h930.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCoronary CirculationDisease Models, AnimalEndothelial Growth FactorsFibroblast Growth Factor 1Heart VentriclesLymphokinesMyocardial ContractionMyocardial IschemiaNeovascularization, PhysiologicRecombinant ProteinsSwineVascular Endothelial Growth Factor AVascular Endothelial Growth Factors
1997
Extent of myocardial collateralization: Determination with three-dimensional elastic-subtraction spiral CT
Pearlman J, Laham R, Simons M, Gladstone S, Raptopoulos V. Extent of myocardial collateralization: Determination with three-dimensional elastic-subtraction spiral CT. Academic Radiology 1997, 4: 680-686. PMID: 9344290, DOI: 10.1016/s1076-6332(97)80139-0.Peer-Reviewed Original Research
1996
Direct Vasomotor Effects of Isoflurane in Subepicardial Resistance Vessels from Collateral-dependent and Normal Coronary Circulation of Pigs
Park K, Lowenstein E, Dai H, Lopez J, Stamler A, Simons M, Sellke F. Direct Vasomotor Effects of Isoflurane in Subepicardial Resistance Vessels from Collateral-dependent and Normal Coronary Circulation of Pigs. Anesthesiology 1996, 85: 584-591.. PMID: 8853089, DOI: 10.1097/00000542-199609000-00018.Peer-Reviewed Original ResearchMeSH KeywordsAnesthetics, InhalationAnimalsCollateral CirculationCoronary CirculationCoronary VesselsFemaleIsofluraneMaleSwineVasoconstrictionVasodilationConceptsDirect vasomotor effectResistance vesselsVasomotor effectsNormal vesselsCoronary arteryEndothelin-1Sodium nitroprussideEndothelium-independent dilator sodium nitroprussideNormal coronary circulationResistance coronary arteriesCoronary resistance vesselsChronic coronary occlusionConcentration-dependent constrictionThromboxane analog U46619 1 microMLeft circumflex arteryRapid atrial pacingMyocardial blood flowEndothelial dysfunctionVasoconstrictive effectAtrial pacingCircumflex arteryCoronary occlusionConstrictive effectOccluder placementCoronary circulationAngiogenesis induced by acidic fibroblast growth factor as an alternative method of revascularization for chronic myocardial ischemia
Sellke F, Li J, Stamler A, Lopez J, Thomas K, Simons M. Angiogenesis induced by acidic fibroblast growth factor as an alternative method of revascularization for chronic myocardial ischemia. Surgery 1996, 120: 182-188. PMID: 8751581, DOI: 10.1016/s0039-6060(96)80286-8.Peer-Reviewed Original ResearchConceptsCollateral-dependent LCx regionAcidic fibroblast growth factorFibroblast growth factorLCx regionBlood flowSodium nitroprussideProximal left circumflex coronary arterySevere coronary artery diseaseLeft circumflex coronary arteryGrowth factorCoronary arterial microvesselsCoronary microvascular reactivityProximal (<b>d</b>) LCX arteryEndothelium-dependent mechanismEndothelium-dependent relaxationCircumflex coronary arteryCollateral-dependent myocardiumCoronary artery diseaseTreatment of patientsGuanylate cyclase activators sodium nitroprussideChronic myocardial ischemiaAdenylate cyclase activator forskolinPeriadventitial administrationCyclase activator forskolinMicrovascular reactivity
1995
β-Adrenergic Modulation of the Collateral-Dependent Coronary Microcirculation
Sellke F, Wang S, Friedman M, Bin Dai H, Harada K, Lopez J, Simons M. β-Adrenergic Modulation of the Collateral-Dependent Coronary Microcirculation. Journal Of Surgical Research 1995, 59: 185-190. PMID: 7630126, DOI: 10.1006/jsre.1995.1152.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorCollateral-dependent LCx regionLCx regionCoronary microcirculationBlood flowProximal left circumflex coronary arteryLeft circumflex coronary arteryCollateral-dependent areaCollateral-dependent perfusionCoronary arterial microvesselsCoronary microvascular responsesLCX blood flowProximal (<b>d</b>) LCX arteryCircumflex coronary arteryCollateral-dependent myocardiumRapid atrial pacingEndothelial growth factorΒ-Adrenergic ModulationAdenylate cyclase activator forskolinRelaxations of microvesselsCyclase activator forskolinChronic treatmentLeft anteriorMicrovascular relaxationAtrial pacing