2000
PR39, a peptide regulator of angiogenesis
Li J, Post M, Volk R, Gao Y, Li M, Metais C, Sato K, Tsai J, Aird W, Rosenberg R, Hampton T, Li J, Sellke F, Carmeliet P, Simons M. PR39, a peptide regulator of angiogenesis. Nature Medicine 2000, 6: 49-55. PMID: 10613823, DOI: 10.1038/71527.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimicrobial Cationic PeptidesAortaCapillariesCattleCell HypoxiaCells, CulturedCoronary VesselsCysteine EndopeptidasesDNA-Binding ProteinsEndothelium, VascularHeartHumansHypoxia-Inducible Factor 1Hypoxia-Inducible Factor 1, alpha SubunitIn Vitro TechniquesMacrophagesMiceMice, Inbred C57BLMice, TransgenicMultienzyme ComplexesMyocardial InfarctionMyocardial IschemiaNeovascularization, PhysiologicNuclear ProteinsPeptidesProteasome Endopeptidase ComplexRecombinant ProteinsSwineTranscription FactorsUbiquitinsUmbilical VeinsVon Willebrand FactorConceptsHypoxia-inducible factor-1α (HIF-1α) degradationMacrophage-derived peptideHypoxia-inducible factor-1α (HIF-1α) proteinCoronary flow studiesInflammation-induced angiogenesisInduction of angiogenesisMyocardial vasculatureTissue injuryPotent inductorFunctional blood vesselsBlood vesselsVascular structuresAngiogenesisSelective inhibitionPR39
1997
c‐Myb function in fibroblasts
Bein K, Husain M, Ware J, Mucenski M, Rosenberg R, Simons M. c‐Myb function in fibroblasts. Journal Of Cellular Physiology 1997, 173: 319-326. PMID: 9369944, DOI: 10.1002/(sici)1097-4652(199712)173:3<319::aid-jcp3>3.0.co;2-q.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAnimalsCalciumCell CycleCells, CulturedCytoplasmDNA-Binding ProteinsDrosophilaEmbryo, MammalianEmbryo, NonmammalianFibroblastsHeterozygoteHomeodomain ProteinsMiceMice, KnockoutProto-Oncogene ProteinsProto-Oncogene Proteins c-mybRecombinant Fusion ProteinsTrans-ActivatorsTranscription FactorsTranscription, GeneticTransfectionConceptsC-Myb proteinDominant-negative constructMyb DNA binding domainC-MybMYB family membersDNA binding domainsNegative constructsCell cycle regulationSignificant sequence homologyC-myb geneMouse embryonic fibroblastsC-Myb functionCell cycle progressionCell type expressionProtooncogene c-mybNIH 3T3 fibroblastsCell cycle arrestG1 cell cycle arrestNuclear transcription factorA-mybCycle regulationIntracellular calcium levelsB-MybTranscription factorsCDNA sequence