Clinical Trials in Coronary Angiogenesis: Issues, Problems, Consensus
Simons M, Bonow R, Chronos N, Cohen D, Giordano F, Hammond H, Laham R, Li W, Pike M, Sellke F, Stegmann T, Udelson J, Rosengart T. Clinical Trials in Coronary Angiogenesis: Issues, Problems, Consensus. Circulation 2000, 102: e73-86. PMID: 10982554, DOI: 10.1161/01.cir.102.11.e73.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis Inducing AgentsAnimalsClinical Trials as TopicCoronary AngiographyCoronary VesselsEndothelial Growth FactorsFibroblast Growth Factor 2Genetic TherapyHeart DiseasesHumansLymphokinesMagnetic Resonance ImagingNeovascularization, PhysiologicPatient SelectionTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsClinical trialsCoronary angiogenesisAdvanced ischemic heart diseaseAngiogenic growth factor therapySide effect profileIschemic heart diseaseGrowth factor therapyAppropriate patient populationAmerican Heart AssociationNew treatment strategiesTherapeutic end pointRoute of administrationBiology of angiogenesisNew blood supplyFactor therapyCoronary diseaseEffect profilePatient populationHeart AssociationHeart diseaseTreatment strategiesBlood supplyTherapeutic strategiesPreclinical investigationsTherapeutic angiogenesisTherapeutic Angiogenesis Using Local Perivascular and Pericardial Delivery.
Laham R, Post M, Sellke F, Simons M. Therapeutic Angiogenesis Using Local Perivascular and Pericardial Delivery. Current Interventional Cardiology Reports 2000, 2: 213-217. PMID: 11096670.Peer-Reviewed Original ResearchIschemic heart diseaseTherapeutic angiogenesisHeart diseaseCoronary artery bypass surgeryPericardial deliveryPotential new treatment strategyLocal perivascular deliveryArtery bypass surgeryNew treatment strategiesGrowth factor-induced angiogenesisClinical therapeutic angiogenesisNew blood vesselsBypass surgeryPerivascular deliveryIschemic myocardiumEpicardial vesselsTreatment strategiesAngiogenic cytokinesTheoretic advantagesSustained exposureBlood vesselsAngiogenesisDelivery modalitiesLimited dataPoor understanding