2019
High-throughput screening discovers antifibrotic properties of haloperidol by hindering myofibroblast activation
Rehman M, Vodret S, Braga L, Guarnaccia C, Celsi F, Rossetti G, Martinelli V, Battini T, Long C, Vukusic K, Kocijan T, Collesi C, Ring N, Skoko N, Giacca M, Del Sal G, Confalonieri M, Raspa M, Marcello A, Myers MP, Crovella S, Carloni P, Zacchigna S. High-throughput screening discovers antifibrotic properties of haloperidol by hindering myofibroblast activation. JCI Insight 2019, 4: e123987. PMID: 30996132, PMCID: PMC6538355, DOI: 10.1172/jci.insight.123987.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCalciumCell DifferentiationCells, CulturedDisease Models, AnimalDrug RepositioningEndoplasmic Reticulum StressFibrosisHaloperidolHumansIntravital MicroscopyLungMiceMyocardiumMyofibroblastsOptical ImagingPrimary Cell CultureReceptor, Notch1Receptors, sigmaRNA InterferenceRNA, Small InterferingSignal TransductionConceptsMyofibroblast activationSigma receptor 1Smooth muscle actinDifferent animal modelsTransforming Growth FactorDiscovery of haloperidolTumor-associated fibrosisMechanism of actionEndoplasmic reticulum stress responseFibrotic burdenAntifibrotic effectsAntifibrotic propertiesCommon antipsychotic drugsAntipsychotic drugsFibrotic processIntracellular calciumReticulum stress responseAnimal modelsMuscle actinFibrotic conditionsHaloperidolReceptor 1Growth factorContractile proteinsTherapeutic solutions
2018
Taming the Notch Transcriptional Regulator for Cancer Therapy
Tamagnone L, Zacchigna S, Rehman M. Taming the Notch Transcriptional Regulator for Cancer Therapy. Molecules 2018, 23: 431. PMID: 29462871, PMCID: PMC6017063, DOI: 10.3390/molecules23020431.Peer-Reviewed Original Research
2016
PlexinD1 Is a Novel Transcriptional Target and Effector of Notch Signaling in Cancer Cells
Rehman M, Gurrapu S, Cagnoni G, Capparuccia L, Tamagnone L. PlexinD1 Is a Novel Transcriptional Target and Effector of Notch Signaling in Cancer Cells. PLOS ONE 2016, 11: e0164660. PMID: 27749937, PMCID: PMC5066946, DOI: 10.1371/journal.pone.0164660.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzazepinesCadherinsCell Adhesion Molecules, NeuronalCell Line, TumorCell MovementDiaminesDown-RegulationEnzyme InhibitorsHEK293 CellsHuman Umbilical Vein Endothelial CellsHumansIntracellular Signaling Peptides and ProteinsJagged-1 ProteinLung NeoplasmsMembrane GlycoproteinsMiceMice, Inbred NODMice, SCIDMicroscopy, FluorescencePromoter Regions, GeneticReceptors, NotchRNA InterferenceRNA, MessengerRNA, Small InterferingSignal TransductionSnail Family Transcription FactorsThiazolesTransplantation, HeterologousUp-RegulationConceptsNovel transcriptional targetProstate cancer cell migrationCell migrationCancer cell migrationTranscriptional targetsNotch signalingPlexinD1 expressionE-cadherin levelsCancer cellsProstate cancer cellsE-cadherin regulationAbsence of NotchPromoter activity reporterCancer cell invasivenessTranscription factor SlugProstate cancerProstate cancer cell invasivenessTranscriptional activationNotch receptorsActivity reporterDownstream eventsAxis downstreamNotch ligandsFunctional rescuePlexinD1
2012
Semaphorins in cancer: Biological mechanisms and therapeutic approaches
Rehman M, Tamagnone L. Semaphorins in cancer: Biological mechanisms and therapeutic approaches. Seminars In Cell And Developmental Biology 2012, 24: 179-189. PMID: 23099250, DOI: 10.1016/j.semcdb.2012.10.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease ProgressionHumansMolecular Targeted TherapyNeoplasmsSemaphorinsSignal TransductionConceptsResponsive cell typesHallmarks of cancerMultiple experimental approachesEpigenetic changesSemaphorin signalsPhysiological processesCell migrationPivotal signalsCell typesReceptor complexCell proliferationSemaphorinsCancer cellsDifferent semaphorinsBiological mechanismsHuman tumorsTumor progressionMultiple alterationsTumor angiogenesisPathwayExperimental approachFamily membersTumor microenvironmentImportant roleCells
2009
Notch1 regulates the functional contribution of RhoC to cervical carcinoma progression
Srivastava S, Ramdass B, Nagarajan S, Rehman M, Mukherjee G, Krishna S. Notch1 regulates the functional contribution of RhoC to cervical carcinoma progression. British Journal Of Cancer 2009, 102: 196-205. PMID: 19953094, PMCID: PMC2813755, DOI: 10.1038/sj.bjc.6605451.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnoikisCarcinoma, Squamous CellCell DivisionCell Line, TumorCell MovementCell TransdifferentiationDisease ProgressionFemaleGene Knockdown TechniquesHumansMiceMice, NudeNeoplasm InvasivenessNeoplasm ProteinsNeovascularization, PathologicReceptor, Notch1Rho GTP-Binding ProteinsRhoC GTP-Binding ProteinRNA, Small InterferingSignal TransductionTumor Stem Cell AssayUterine Cervical NeoplasmsConceptsCervical carcinoma progressionRhoC protein expressionHuman cervical cancerCervical carcinoma cell linesPro-oncogenic roleHuman epithelial cancersNotch1 inactivationCervical cancerCarcinoma cell linesCervical carcinomaImmunohistochemical studyRole of NotchActive RhoCEpithelial cancersCarcinoma progressionSiHa cellsMesenchymal transitionNotch1 inhibitionWestern blottingProtein expressionClinical sectionTumor formationRhoC expressionColony formationTube formation
2006
Coexpression of Notch1 and NF-κB signaling pathway components in human cervical cancer progression
Ramdass B, Maliekal TT, Lakshmi S, Rehman M, Rema P, Nair P, Mukherjee G, Reddy BK, Krishna S, Pillai M. Coexpression of Notch1 and NF-κB signaling pathway components in human cervical cancer progression. Gynecologic Oncology 2006, 104: 352-361. PMID: 17098279, DOI: 10.1016/j.ygyno.2006.08.054.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, Squamous CellCell Line, TumorCell NucleusDisease ProgressionFemaleHumansImmunohistochemistryMiceMice, NudeNF-kappa BPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-fosReceptor, Notch1Signal TransductionTransplantation, HeterologousTumor Suppressor Protein p53Uterine Cervical DysplasiaUterine Cervical NeoplasmsConceptsHuman cervical cancerCervical cancerNF-kappaB p50Cancer tissuesCaSki cellsHuman cervical cancer progressionNF-kappaB.Human cervical cancer tissuesCervical cancer tissuesSquamous cell carcinomaNormal cervical tissuesCervical cancer progressionCervical tissue samplesCell line CaSkiExpression of Notch1NF-kappaB activationNF-kappaB p65Human cancer tissuesUpstream regulatorUterine cervixCell carcinomaPreinvasive lesionsCervical tissueNF-κBIkappaB-alpha