2019
Loss of Protein Kinase Csnk2b/CK2β at Neuromuscular Junctions Affects Morphology and Dynamics of Aggregated Nicotinic Acetylcholine Receptors, Neuromuscular Transmission, and Synaptic Gene Expression
Eiber N, Rehman M, Kravic B, Rudolf R, Sandri M, Hashemolhosseini S. Loss of Protein Kinase Csnk2b/CK2β at Neuromuscular Junctions Affects Morphology and Dynamics of Aggregated Nicotinic Acetylcholine Receptors, Neuromuscular Transmission, and Synaptic Gene Expression. Cells 2019, 8: 940. PMID: 31434353, PMCID: PMC6721821, DOI: 10.3390/cells8080940.Peer-Reviewed Original ResearchConceptsSynaptic gene expressionGene expressionNicotinic acetylcholine receptorsClustering of AChRsNeuromuscular junctionCultured muscle cellsAcetylcholine receptorsDistinctive proteinsCK2Neuromuscular transmissionAChR clustersΒ-subunitCompound muscle action potentialHigh turnover rateCK2βCell proliferationMuscle action potentialsNMJ fragmentationSkeletal muscle fibersPrecise roleAge-dependent decreaseMuscle cellsAcetylcholine esterase inhibitorsAChRExpression
2009
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions. Science 2009, 325: 834-840. PMID: 19608861, DOI: 10.1126/science.1175371.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAmino Acid MotifsBenzamidesCell Line, TumorCell NucleusCell Physiological PhenomenaCytoplasmEnzyme InhibitorsHistone Deacetylase InhibitorsHistone DeacetylasesHumansHydroxamic AcidsLysineMass SpectrometryMetabolic Networks and PathwaysMitochondriaMultiprotein ComplexesProtein Processing, Post-TranslationalProtein Structure, TertiaryProteinsProteomeProteomicsPyridinesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsVorinostatConceptsLysine acetylationCellular rolesPosttranslational modificationsCyclin-dependent kinase Cdc28Phosphorylation-dependent interactionReversible posttranslational modificationDiverse cellular processesMajor cellular functionsTarget protein complexesMajor posttranslational modificationLarge macromolecular complexesLysine acetylation sitesChromatin remodelingActin nucleationNuclear transportProtein complexesCellular functionsCellular processesAcetylation sitesMacromolecular complexesAcetylation changesGene expressionCell cycleDeacetylase inhibitorsAcetylation