Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction
Zacchigna S, Martinelli V, Moimas S, Colliva A, Anzini M, Nordio A, Costa A, Rehman M, Vodret S, Pierro C, Colussi G, Zentilin L, Gutierrez MI, Dirkx E, Long C, Sinagra G, Klatzmann D, Giacca M. Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction. Nature Communications 2018, 9: 2432. PMID: 29946151, PMCID: PMC6018668, DOI: 10.1038/s41467-018-04908-z.Peer-Reviewed Original ResearchConceptsRegulatory T cellsMyocardial infarctionTreg depletionCardiomyocyte proliferationT cellsRole of TregsDepressed cardiac functionFetal cardiomyocyte proliferationPregnancy decreasesInfarct sizeMaternal toleranceMassive inflammationPregnant mothersCardiac functionMaternal bloodTherapeutic effectParacrine mannerTregsCollagen depositionParacrine effectsPregnant animalsInfarctionProliferationCardiomyocytesProliferative cardiomyocytes