miR-200 family members reduce senescence and restore idiopathic pulmonary fibrosis type II alveolar epithelial cell transdifferentiation
Moimas S, Salton F, Kosmider B, Ring N, Volpe MC, Bahmed K, Braga L, Rehman M, Vodret S, Graziani ML, Wolfson MR, Marchetti N, Rogers TJ, Giacca M, Criner GJ, Zacchigna S, Confalonieri M. miR-200 family members reduce senescence and restore idiopathic pulmonary fibrosis type II alveolar epithelial cell transdifferentiation. ERJ Open Research 2019, 5: 00138-2019. PMID: 31857992, PMCID: PMC6911923, DOI: 10.1183/23120541.00138-2019.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisMiR-200 family membersEpithelial-mesenchymal transitionATII cellsEMT markersATI cellsMarker expressionFamily membersRegenerative potentialAlveolar type II cellsType II cellsIPF patientsSenescence marker expressionIPF lungsMiR-200 familyPulmonary fibrosisEpithelial cell transdifferentiationCell markersImpaired expressionFamilial casesCell transdifferentiationII cellsSenescent phenotypeMicroRNA effectsTransdifferentiation