2023
A Mouse Model of MHV‐1 Virus Infection for Study of Acute and Long COVID Infection
Masciarella A, Di Gregorio D, Ramamoorthy R, Hussain H, Jayakumar A, Paidas M. A Mouse Model of MHV‐1 Virus Infection for Study of Acute and Long COVID Infection. Current Protocols 2023, 3: e896. PMID: 37867460, PMCID: PMC10606938, DOI: 10.1002/cpz1.896.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Pathological changesMouse modelTransgenic miceLong-term organ dysfunctionSARS-CoV-2 pathophysiologyIrreversible neurological complicationsPotential therapeutic interventionsAvailable human dataBiosafety level 2 laboratoryNon-human primatesBiosafety level 3 laboratoryNeurological complicationsOrgan dysfunctionAcute stageClinical symptomsLong-term effectsSevere casesClinical observationsViral infectionTherapeutic interventionsMHV-1Animal preparationsWeight lossBSL-3 laboratory
2012
PreImplantation Factor Reduces Graft-versus-Host Disease by Regulating Immune Response and Lowering Oxidative Stress (Murine Model)
Azar Y, Shainer R, Almogi-Hazan O, Bringer R, Compton SR, Paidas MJ, Barnea ER, Or R. PreImplantation Factor Reduces Graft-versus-Host Disease by Regulating Immune Response and Lowering Oxidative Stress (Murine Model). Transplantation And Cellular Therapy 2012, 19: 519-528. PMID: 23266739, DOI: 10.1016/j.bbmt.2012.12.011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow TransplantationCell ProliferationDendritic CellsGraft vs Host DiseaseGraft vs Leukemia EffectImmune ToleranceInflammationInterferon-gammaInterleukin-17LiverMiceMice, Inbred BALB CMice, Inbred C57BLNitric Oxide Synthase Type IIOxidative StressPeptidesSkinSpleenSurvival AnalysisT-Lymphocytes, RegulatoryTransplantation, HomologousConceptsBone marrow transplantationBeneficial GVL effectPreImplantation FactorAcute GVHDGVL effectHost diseaseImmune responseInducible nitric oxide synthase (iNOS) expressionAllogeneic bone marrow transplantationNitric oxide synthase expressionOxidative stressIL-17 levelsIFN-γ levelsSystemic immune responsesOxide synthase expressionAntigen-presenting cellsMurine BMT modelT cell proliferationNitric oxide secretionDonor-recipient matchingChemokine gene expressionLipopolysaccharide-activated macrophagesAcute graftAllogeneic embryosBeneficial graft
2011
Preimplantation Factor (PIF*) reverses neuroinflammation while promoting neural repair in EAE model
Weiss L, Or R, Jones RC, Amunugama R, JeBailey L, Ramu S, Bernstein SA, Yekhtin Z, Almogi-Hazan O, Shainer R, Reibstein I, Vortmeyer AO, Paidas MJ, Zeira M, Slavin S, Barnea ER. Preimplantation Factor (PIF*) reverses neuroinflammation while promoting neural repair in EAE model. Journal Of The Neurological Sciences 2011, 312: 146-157. PMID: 21996270, DOI: 10.1016/j.jns.2011.07.050.Peer-Reviewed Original ResearchConceptsInflammatory cellsPro-inflammatory cytokines/chemokinesPreserves islet functionCytokines/chemokinesSignificant neuroprotective effectsSpinal cord histologyPreImplantation FactorSplenocyte cytokinesEAE modelChronic modelNeuroprotective effectsMaternal immunityClinical indicesChronic paralysisSpinal cordJuvenile diabetesMulti-targeted actionSynaptic transmissionCord histologyIslet functionIL6 secretionCoagulation factorsNeural repairClinical testingDay 82
2010
WAG‐F8m1Ycb rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A
BOOTH CJ, BROOKS MB, ROCKWELL S, MURPHY JW, RINDER HM, ZELTERMAN D, PAIDAS MJ, COMPTON SR, MARKS PW. WAG‐F8m1Ycb rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A. Journal Of Thrombosis And Haemostasis 2010, 8: 2472-2477. PMID: 20626616, DOI: 10.1111/j.1538-7836.2010.03978.x.Peer-Reviewed Original ResearchConceptsAutosomal locationX chromosomeGenetic basisFactor VIIITertiary structureChromosome 18Point mutationsA1 domainFactor activityGenetic defectsHuman recombinant factor VIIIPartial thromboplastin timeSpecific coagulation factorsNew animal modelNormal prothrombin timeFactor VIII gene mutationsRecombinant factor VIIIMutationsPeripartum deathsGene mutationsCoagulation abnormalitiesSpontaneous bruisingProthrombin timeFemale ratsNovel therapies
2009
Involvement of human decidual cell-expressed tissue factor in uterine hemostasis and abruption
Lockwood C, Paidas M, Murk W, Kayisli U, Gopinath A, Huang S, Krikun G, Schatz F. Involvement of human decidual cell-expressed tissue factor in uterine hemostasis and abruption. Thrombosis Research 2009, 124: 516-520. PMID: 19720393, PMCID: PMC2787516, DOI: 10.1016/j.thromres.2009.07.017.Peer-Reviewed Original ResearchConceptsDecidual cellsTissue factorPlacental ischemiaTF expressionDecidual cell-expressed tissue factorCultured term decidual cellsAutocrine/paracrine fashionDecidual spiral arteriesDecidual vascular remodelingTerm decidual cellsUteroplacental blood flowMaternal-fetal interfaceAutocrine/paracrine mediatorsDecidual infiltrationHemostatic protectionUterine hemostasisDecidual hemorrhageExtracellular matrixSpiral arteriesFetal interfaceHuman pregnancyVascular injuryConductance vesselsSFlt-1Interleukin-8
2007
Embryo–Placento–Maternal Interaction and Biomarkers: From Diagnosis to Therapy – A Workshop Report
Than N, Paidas M, Mizutani S, Sharma S, Padbury J, Barnea E. Embryo–Placento–Maternal Interaction and Biomarkers: From Diagnosis to Therapy – A Workshop Report. Placenta 2007, 28: s107-s110. PMID: 17382999, PMCID: PMC2574429, DOI: 10.1016/j.placenta.2007.01.017.Peer-Reviewed Original Research