2023
Identifying Pregnancies at Higher Risk for HPA-1a Alloimmunization and Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT): An International, Prospective, Natural History Study
Vander Haar E, Ware C, Allen G, Armstrong R, Black D, Bombara M, Dhanraj D, Lawrence L, Miller R, Nanda S, Paidas M, Patki K, Sitras V, Skupski D, Swarup M, Thorp J, Tiller H, Verweij J, Bussel J. Identifying Pregnancies at Higher Risk for HPA-1a Alloimmunization and Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT): An International, Prospective, Natural History Study. Blood 2023, 142: 1224. DOI: 10.1182/blood-2023-177657.Peer-Reviewed Original ResearchFetal/Neonatal Alloimmune ThrombocytopeniaHPA-1a alloimmunizationNeonatal alloimmune thrombocytopeniaPregnant womenHuman platelet antigensNatural history studiesFetal deathNeonatal thrombocytopeniaSecond trimesterPlatelet countAlloimmune thrombocytopeniaRisk pregnanciesWeek 10HPA-1a negative womenAdministration of prophylaxisAntenatal intravenous immunoglobulinHPA-1bb womenLifelong neurological impairmentMultiple European centersSevere neonatal thrombocytopeniaHigh-risk womenSingle-arm studyFetal platelet countGestational weeks 10First epidemiological study
2020
Thromboembolism
Paidas M. Thromboembolism. 2020, 181-200. DOI: 10.1002/9781119635307.ch19.Peer-Reviewed Original ResearchDeep venous thrombosisVenous thromboembolismRisk of DVTRisk of VTETransient hypercoagulable stateLeft lower extremityPrimary diagnostic modalitySystemic coagulationThromboembolic eventsNonpregnant womenFetal risksHypercoagulable stateVenous thrombosisVenous ultrasoundHemostatic challengesPregnant womenVascular traumaRisk factorsLower extremitiesVascular stasisDiagnostic modalitiesHormonal changesColor DopplerFibrinolytic systemPregnancy
2015
Dose Selection of Antithrombin (Recombinant) for a Phase 3 Trial in Early-Onset Preeclampsia [149]
Paidas M, Frieling J, de Jongh J, Drenth H, Streisand J. Dose Selection of Antithrombin (Recombinant) for a Phase 3 Trial in Early-Onset Preeclampsia [149]. Obstetrics And Gynecology 2015, 125: 52s. DOI: 10.1097/01.aog.0000463689.71574.8f.Peer-Reviewed Original ResearchEarly-onset preeclampsiaRecombinant human antithrombinPhase 3 trialPopulation pharmacokinetic modelingHuman antithrombinAntithrombin deficiencyPlasma antithrombinPharmacokinetic modelingHereditary antithrombin deficiencyPopulation pharmacokinetic modelAntithrombin activity levelsDifferent pharmacokinetic propertiesPrior human studiesExpectant managementPerinatal morbidityPregnant patientsLoading doseMaternal administrationPregnant womenContinuous infusionSimilar efficacyClinical studiesPleiotropic effectsAntithrombin treatmentDose selection
2012
Thrombophilias and adverse pregnancy outcomes: results from the Danish National Birth Cohort
LYKKE JA, BARE LA, OLSEN J, LAGIER R, ARELLANO AR, TONG C, PAIDAS MJ, LANGHOFF‐ROOS J. Thrombophilias and adverse pregnancy outcomes: results from the Danish National Birth Cohort. Journal Of Thrombosis And Haemostasis 2012, 10: 1320-1325. PMID: 22578003, DOI: 10.1111/j.1538-7836.2012.04773.x.Peer-Reviewed Original ResearchConceptsMethylenetetrahydrofolate reductase (MTHFR) C677TFetal growth restrictionProthrombin mutation G20210APlacental abruptionSevere preeclampsiaGrowth restrictionAllelic modelAdverse pregnancy outcomesBody mass indexCase-cohort studyReductase C677TPreterm deliveryComposite outcomePregnancy outcomesMass indexPregnant womenMedical recordsC677TFV LeidenStudy designSocioeconomic statusPreeclampsiaAbruptionRandom controlsOutcomesAmerican Thoracic Society Documents: An Official American Thoracic Society/Society of Thoracic Radiology Clinical Practice Guideline—Evaluation of Suspected Pulmonary Embolism in Pregnancy
Leung AN, Bull TM, Jaeschke R, Lockwood CJ, Boiselle PM, Hurwitz LM, James AH, McCullough LB, Menda Y, Paidas MJ, Royal HD, Tapson VF, Winer-Muram HT, Chervenak FA, Cody DD, McNitt-Gray MF, Stave CD, Tuttle BD. American Thoracic Society Documents: An Official American Thoracic Society/Society of Thoracic Radiology Clinical Practice Guideline—Evaluation of Suspected Pulmonary Embolism in Pregnancy. Radiology 2012, 262: 635-646. PMID: 22282185, DOI: 10.1148/radiol.11114045.Peer-Reviewed Original ResearchPulmonary embolismDigital subtraction angiographyLow-quality evidenceGrades of RecommendationSuspected Pulmonary EmbolismEvidence-based guidelinesPrevention of deathImportant health issueAccurate diagnostic approachCumulative radiation doseClinical research dataAppropriate prophylaxisClinical suspicionLung scintigraphyPregnant womenMaternal mortalityQuality evidenceLeading causeChest radiographyMultidisciplinary panelDiagnostic yieldNormal CXRGeneral populationHigh indexGuideline evaluation
2010
Hematologic Changes in Pregnancy
Paidas M, Hossain N. Hematologic Changes in Pregnancy. 2010, 1-11. DOI: 10.1002/9781444328332.ch1.Peer-Reviewed Original ResearchWeeks of gestationHemoglobin levelsThird trimesterPregnant womenTotal white blood cellsMajor hematological changesRed blood cell massAbsolute lymphocyte countCells/microL.Healthy nonpregnant womenHealthy pregnant womenEnd of pregnancyBlood cell massWhite blood cellsPlasma volume increasePhysiologic anemiaLymphocyte countNeutrophil countNonpregnant womenPlatelet countProcoagulant factorsSecond trimesterNonpregnant levelsHematologic changesMild thrombocytopenia
2009
Pulmonary embolism in pregnancy
Bourjeily G, Paidas M, Khalil H, Rosene-Montella K, Rodger M. Pulmonary embolism in pregnancy. The Lancet 2009, 375: 500-512. PMID: 19889451, DOI: 10.1016/s0140-6736(09)60996-x.Peer-Reviewed Original ResearchConceptsPulmonary embolismRisk of complicationsBest possible treatmentPotential adverse effectsAppropriate prophylaxisVenous thromboembolismRisk stratificationVenous stasisPregnant womenVascular damageVirchow's triadFetal teratogenicityMaternal mortalityPharmacological treatmentTherapeutic interventionsPregnancyPossible treatmentAccurate diagnosisDiagnostic testingRight populationAdverse effectsEmbolismMortalityPhysiological changesDiagnosisLiver dysfunction in pregnancy: an important cause of maternal and perinatal morbidity and mortality in Pakistan
Hossain N, Shamsi T, Kuczynski E, Lockwood C, Paidas M. Liver dysfunction in pregnancy: an important cause of maternal and perinatal morbidity and mortality in Pakistan. Obstetric Medicine 2009, 2: 17-20. PMID: 27582800, PMCID: PMC4989777, DOI: 10.1258/om.2008.080028.Peer-Reviewed Original ResearchFulminant hepatic failureLiver dysfunctionHepatitis EMaternal deathsPregnant womenStudy populationProspective observational study designAcute hepatitis EOverall perinatal mortalityUnderwent caesarean sectionAcute fatty liverAbnormal coagulation parametersCivil Hospital KarachiObservational study designHELLP syndromeHospital KarachiPerinatal morbidityPerinatal outcomesCaesarean sectionHepatic failureHepatitis A.Perinatal mortalityFatty liverThird trimesterSecond trimester
2008
Genetic influences on smoking cessation and relapse in pregnant women
Triche E, Hossain N, Paidas M. Genetic influences on smoking cessation and relapse in pregnant women. Journal Of Obstetrics And Gynaecology 2008, 28: 155-160. PMID: 18393009, DOI: 10.1080/01443610801912725.Peer-Reviewed Original ResearchConceptsLow birth weight infantsBirth weight infantsPregnant womenWeight infantsSmoking behaviorNegative long-term health consequencesLong-term health consequencesPre-term deliverySignificant public health concernFetal growth restrictionLow birth weightPublic health concernAuditory processing deficitsMaternal smokingObstetrical complicationsPlacental problemsCigarette smokingSmoking cessationBirth weightGrowth restrictionSpontaneous abortionPlacental functionLong-term consequencesRespiratory conditionsGenetic influences