2009
Involvement of human decidual cell-expressed tissue factor in uterine hemostasis and abruption
Lockwood C, Paidas M, Murk W, Kayisli U, Gopinath A, Huang S, Krikun G, Schatz F. Involvement of human decidual cell-expressed tissue factor in uterine hemostasis and abruption. Thrombosis Research 2009, 124: 516-520. PMID: 19720393, PMCID: PMC2787516, DOI: 10.1016/j.thromres.2009.07.017.Peer-Reviewed Original ResearchConceptsDecidual cellsTissue factorPlacental ischemiaTF expressionDecidual cell-expressed tissue factorCultured term decidual cellsAutocrine/paracrine fashionDecidual spiral arteriesDecidual vascular remodelingTerm decidual cellsUteroplacental blood flowMaternal-fetal interfaceAutocrine/paracrine mediatorsDecidual infiltrationHemostatic protectionUterine hemostasisDecidual hemorrhageExtracellular matrixSpiral arteriesFetal interfaceHuman pregnancyVascular injuryConductance vesselsSFlt-1Interleukin-8
2004
Term Decidual Cell Thrombomodulin and Endothelial Protein C Receptor Expression Is Upregulated by Thrombin Irrespective of Ovarian Hormonal Priming.
Paidas M, Ku D, Arkel Y, Tang C, Fortunato C, Lockwood C. Term Decidual Cell Thrombomodulin and Endothelial Protein C Receptor Expression Is Upregulated by Thrombin Irrespective of Ovarian Hormonal Priming. Blood 2004, 104: 1947. DOI: 10.1182/blood.v104.11.1947.1947.Peer-Reviewed Original ResearchAdverse pregnancy outcomesDecidual cellsExpression of TMReal-time PCRAddition of hirudinEndothelial protein C receptor expressionTime PCRIntrauterine growth restrictionPro-inflammatory processesMaternal-fetal interfaceTM protein expressionProtein C systemHormonal primingUteroplacental thrombosisWestern blot analysisAbruptio placentaeGeneration of APCCesarean sectionPregnancy outcomesNormal pregnancyProthrombotic milieuUncomplicated pregnanciesFetal interfaceGestational ageMedroxy progesteroneElevated sEPCR and PAI-1 Levels, but Not sThrombomodulin Levels in Normal Pregnancy.
Arkel Y, Paidas M, Ku D, Triche E, Lam X, Ku E, Lockwood C. Elevated sEPCR and PAI-1 Levels, but Not sThrombomodulin Levels in Normal Pregnancy. Blood 2004, 104: 3996. DOI: 10.1182/blood.v104.11.3996.3996.Peer-Reviewed Original ResearchEndothelial protein C receptorAdverse pregnancy outcomesPro-inflammatory cytokinesNormal pregnancyProtein C systemDecidual cellsEndothelial cellsProtein SEndometrial decidual cellsNon-pregnant controlsProtein C receptorCell surface proteinsPlasminogen activator inhibitorCell-surface thrombomodulinPregnancy outcomesProthrombotic statePlasma thrombomodulinNP patientsEC damageSurface proteinsControl of thrombosisSTM levelsTrimester samplesPregnancyFibrinolytic system
2003
Human decidual cells express components of the activated protein c system: a model for prothrombotic related adverse pregnancy outcomes
Paidas M, Ku D, Arkel Y, Schatz F, Tang C, Rahman M, Thurston A, Lockwood C. Human decidual cells express components of the activated protein c system: a model for prothrombotic related adverse pregnancy outcomes. American Journal Of Obstetrics And Gynecology 2003, 189: s190. DOI: 10.1016/j.ajog.2003.10.481.Peer-Reviewed Original Research