2000
Atypical fatal hypocomplementemic urticarial vasculitis with involvement of native and homograft aortic valves in an African American man
Hong L, Wackers F, Dewar M, Kashgarian M, Askenase P. Atypical fatal hypocomplementemic urticarial vasculitis with involvement of native and homograft aortic valves in an African American man. Journal Of Allergy And Clinical Immunology 2000, 106: 1196-1198. PMID: 11112906, DOI: 10.1067/mai.2000.110805.Peer-Reviewed Original Research
1994
The benefit of early treatment with immunosuppressive agents in lupus nephritis.
Esdaile J, Joseph L, MacKenzie T, Kashgarian M, Hayslett J. The benefit of early treatment with immunosuppressive agents in lupus nephritis. The Journal Of Rheumatology 1994, 21: 2046-51. PMID: 7869308.Peer-Reviewed Original ResearchConceptsHour urinary protein excretionUrinary protein excretionLead-time biasRenal biopsyLupus nephritisRenal insufficiencyRenal involvementSerum creatinineProtein excretionImmunosuppressive agentsEarly treatmentHigh-dose prednisoneLupus renal involvementSubsequent renal insufficiencyTime biasFirst renal biopsySelection biasDose prednisoneTubulointerstitial indexRenal diseaseLongterm prognosisImmunosuppressive drugsEffect of durationBiopsySignificant associationLupus nephritis: Lessons from the path lab
Kashgarian M. Lupus nephritis: Lessons from the path lab. Kidney International 1994, 45: 928-938. PMID: 8196299, DOI: 10.1038/ki.1994.123.Peer-Reviewed Original ResearchThe Time‐Dependence of Long‐Term Prediction in Lupus Nephritis
Esdaile J, Abrahamowicz M, Mackenzie T, Hayslett J, Kashgarian M. The Time‐Dependence of Long‐Term Prediction in Lupus Nephritis. Arthritis & Rheumatism 1994, 37: 359-368. PMID: 8129791, DOI: 10.1002/art.1780370309.Peer-Reviewed Original ResearchConceptsDisease activity measuresLupus nephritisRenal failureActivity measuresLupus nephritis patientsRenal failure outcomeObservation periodCox model analysisLong-term outcomesMean followup timeGood prognostic markerNonrenal outcomesTubulointerstitial indexChronicity indexNephritis patientsRenal outcomesExtended observation periodRenal involvementComorbid diseasesPrognostic factorsRenal functionDevelopment of diseaseRenal biopsyFollowup timeLaboratory predictors
1992
Can Experienced Clinicians Predict the Outcome of Lupus Nephritis?
Esdaile J, Mackenzie T, Barré P, Danoff D, Kirk Osterland C, Somerville P, Quintal H, Kashgarian M, Suissa S. Can Experienced Clinicians Predict the Outcome of Lupus Nephritis? Lupus 1992, 1: 205-214. PMID: 1301984, DOI: 10.1177/096120339200100403.Peer-Reviewed Original Research
1991
Predictors of one year outcome in lupus nephritis: the importance of renal biopsy.
Esdaile J, Federgreen W, Quintal H, Suissa S, Hayslett J, Kashgarian M. Predictors of one year outcome in lupus nephritis: the importance of renal biopsy. QJM 1991, 81: 907-18. PMID: 1808631.Peer-Reviewed Original ResearchConceptsLupus nephritisRenal biopsyBiopsy variablesHigher activity index scoreDiffuse proliferative lupus nephritisSubepithelial electron-dense depositsDiffuse proliferative nephritisActivity index scoreProliferative lupus nephritisShort-term prognosisTime of biopsyClinical predictive modelClinical prediction modelElectron-dense depositsTubulointerstitial scoresNew predictive informationRenal injurySerum creatinineGroups of subjectsLaboratory predictorsPlatelet countUnivariate analysisClinical signsYear outcomesIndividual patients
1989
The clinical and renal biopsy predictors of long-term outcome in lupus nephritis: a study of 87 patients and review of the literature.
Esdaile J, Levinton C, Federgreen W, Hayslett J, Kashgarian M. The clinical and renal biopsy predictors of long-term outcome in lupus nephritis: a study of 87 patients and review of the literature. QJM 1989, 72: 779-833. PMID: 2694209.Peer-Reviewed Original ResearchConceptsPresence of vasculitisLong-term outcomesLupus nephritisRenal diseaseClinical modelRenal insufficiencyRenal failurePrognostic markerRelevant long-term outcomesRenal systemic lupus erythematosusImmunologic disease activityNon-renal SLESystemic lupus erythematosusImportant prognostic markerChronicity indexRenal outcomesRenal severityDisease activityNew predictive informationSerum creatinineConsecutive patientsLupus erythematosusPrognostic factorsRenal biopsyComorbid conditions
1985
Lyme arthritis. Spirochetes found in synovial microangiopathic lesions.
Johnston Y, Duray P, Steere A, Kashgarian M, Buza J, Malawista S, Askenase P. Lyme arthritis. Spirochetes found in synovial microangiopathic lesions. American Journal Of Pathology 1985, 118: 26-34. PMID: 3966535, PMCID: PMC1887850.Peer-Reviewed Original ResearchConceptsDieterle silver stainObliterative microvascular lesionsSynovial cell hyperplasiaMicroangiopathic lesionsProminent microvasculatureSynovial stromaMicrovascular injuryMicrovascular lesionsVillous hypertrophySynovial specimensCell hyperplasiaSynovial diseaseEndarteritis obliteransLymphoplasmacellular infiltrationStriking depositionNeedle biopsyStromal depositionLyme spirocheteLyme diseaseBlood vesselsPatientsSilver stainLesionsDiseaseSpirochetes
1982
"Clear-cell" change within duct and lobular epithelium of the human breast.
Barwick K, Kashgarian M, Rosen P. "Clear-cell" change within duct and lobular epithelium of the human breast. Anatomic Pathology 1982, 17 (Pt 1): 319-28. PMID: 7122130.Peer-Reviewed Original Research
1981
Wegener's Granulomatosis — Clinical-Pathologic Correlations and Long-Term Course
Appel G, Gee B, Kashgarian M, Hayslett J. Wegener's Granulomatosis — Clinical-Pathologic Correlations and Long-Term Course. American Journal Of Kidney Diseases 1981, 1: 27-37. PMID: 7332000, DOI: 10.1016/s0272-6386(81)80008-x.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseModern immunosuppressive therapyLong-term courseClinical-pathologic entityLong-term reportsImmunosuppressive therapyRenal involvementRenal manifestationsSerum creatinineWegener's granulomatosisRenal diseaseEventual prognosisSingle institutionLight microscopic morphologyPathologic correlationMedical CenterRenal tissueDisease processRespiratory tissuesSpecific diagnosisPotential diagnosisPatientsDiagnosisGranulomatosisBiopsy
1980
Activation of the Classic Complement Pathway in Patients with the C3 Nephritic Factor
McLean R, Siegel N, Kashgarian M. Activation of the Classic Complement Pathway in Patients with the C3 Nephritic Factor. Nephron 1980, 25: 57-64. PMID: 6986570, DOI: 10.1159/000181754.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBasement MembraneBiopsyCapillariesChildComplement ActivationComplement C3 Nephritic FactorComplement Inactivator ProteinsComplement Pathway, ClassicalFemaleFluorescent Antibody TechniqueGlomerulonephritisHemolysisHumansImmunoelectrophoresis, Two-DimensionalKidneyLipodystrophyMagnesiumMaleMicroscopy, ElectronConceptsC3 nephritic factorNephritic factorPartial lipodystrophyClassic complement pathwayDense deposit diseaseDense intramembranous depositsRenal diseaseDeposit diseaseIntramembranous depositsPatientsFactor assaysComplement pathwayComplement componentsUltrastructural evidenceCurrent criteriaLipodystrophyDiseaseType IHemolytic assayMCGNAssaysThe importance of nonrenal involvement in hemolytic-uremic syndrome.
Upadhyaya K, Barwick K, Fishaut M, Kashgarian M, Siegel N. The importance of nonrenal involvement in hemolytic-uremic syndrome. Pediatrics 1980, 65: 115-20. PMID: 7355005, DOI: 10.1542/peds.65.1.115.Peer-Reviewed Original ResearchThe significance of electron dense deposits in mild lupus nephritis.
Domoto D, Kashgarian M, Hayslett J, Adler M, Siegel N. The significance of electron dense deposits in mild lupus nephritis. The Yale Journal Of Biology And Medicine 1980, 53: 317-24. PMID: 7445538, PMCID: PMC2595828.Peer-Reviewed Original ResearchConceptsMild lupusSubendothelial depositsDiffuse proliferative lesionsPercent of patientsDiffuse proliferative glomerulonephritisRate of progressionElectron-dense depositsLupus nephritisSubsequent biopsyPoor prognosisProliferative glomerulonephritisDeteriorating courseMild lesionsProliferative lesionsPatientsProgressionDense depositsLupusLesionsLight microscopyWide variationGlomerulonephritisNephritisBiopsyPrognosis
1977
Postviral myositis: myxovirus-like structures in affected muscle.
Greco T, Askenase P, Kashgarian M. Postviral myositis: myxovirus-like structures in affected muscle. Annals Of Internal Medicine 1977, 86: 193-4. PMID: 835943, DOI: 10.7326/0003-4819-86-2-193.Peer-Reviewed Original Research
1976
PROGNOSTIC INDICES IN LUPUS NEPHRITIS
HECHT B, SIEGEL N, ADLER M, KASHGARIAN M, HAYSLETT J. PROGNOSTIC INDICES IN LUPUS NEPHRITIS. Medicine 1976, 55: 163-181. PMID: 1256313, DOI: 10.1097/00005792-197603000-00005.Peer-Reviewed Original Research
1975
Glomerulonephropathy.
Hayslett J, Siegel N, Kashgarian M. Glomerulonephropathy. Advances In Internal Medicine 1975, 20: 215-48. PMID: 1090119.Peer-Reviewed Original ResearchAdolescentAdultAmyloidosisBasement MembraneBlood Coagulation DisordersChildChild, PreschoolDiabetic NephropathiesFemaleGlomerulonephritisGranulomatosis with PolyangiitisHematuriaHumansImmunoglobulin GImmunoglobulin MKidney DiseasesKidney GlomerulusLupus Erythematosus, SystemicMaleMiddle AgedNephrosis, LipoidProteinuriaStreptococcal InfectionsUremia
1974
Clinical spectrum of postpartum renal failure
Finkelstein F, Kashgarian M, Hayslett J. Clinical spectrum of postpartum renal failure. The American Journal Of Medicine 1974, 57: 649-654. PMID: 4432867, DOI: 10.1016/0002-9343(74)90019-9.Peer-Reviewed Original ResearchConceptsPostpartum renal failureRenal failureFibrin depositionExtensive fibrin depositionFulminant renal failureMinor renal dysfunctionRenal functional abnormalitiesSpectrum of diseaseRenal dysfunctionFatal courseClinical spectrumPostpartum periodRenal abnormalitiesRenal vasculatureFunctional abnormalitiesPatientsAbnormalitiesFailureDysfunctionDiseaseVasculatureSHWARTZMAN REACTION IN AN HL-A-IDENTICAL RENAL ALLOGRAFT
SCHIFF M, GOFFINET J, HENDLER E, RUDDLE N, Kashgarian M, LYTTON B. SHWARTZMAN REACTION IN AN HL-A-IDENTICAL RENAL ALLOGRAFT. Transplantation 1974, 17: 580-583. PMID: 4208389, DOI: 10.1097/00007890-197406000-00006.Peer-Reviewed Original ResearchConceptsShwartzman reactionDiffuse intravascular coagulationIdentical sibling donorsEvidence of sensitizationAntigen mismatchesRenal allograftsIntravascular coagulationKidney transplantSibling donorsNegative bacteremiaHistological examinationSkin transplantationIrreversible cessationSame donorTransplantAllograftsPatientsTransplantationKidneyBacteremiaSteroidsDonorsAntibodiesSensitizationCessation
1973
CLINICOPATHOLOGICAL CORRELATIONS IN THE NEPHROTIC SYNDROME DUE TO PRIMARY RENAL DISEASE
HAYSLETT J, KASHGARIAN M, BENSCH K, SPARGO B, FREEDMAN L, EPSTEIN F. CLINICOPATHOLOGICAL CORRELATIONS IN THE NEPHROTIC SYNDROME DUE TO PRIMARY RENAL DISEASE. Medicine 1973, 52: 93-120. PMID: 4695844, DOI: 10.1097/00005792-197303000-00001.Peer-Reviewed Original ResearchAcute DiseaseAdolescentAdultAgedAutopsyAzathioprineBiopsyChildChild, PreschoolChronic DiseaseFemaleFollow-Up StudiesGlomerulonephritisHumansKidney DiseasesKidney Function TestsMaleMicroscopy, ElectronMiddle AgedNephrosis, LipoidNephrotic SyndromePrednisonePrognosisProteinuriaRemission, SpontaneousSerum AlbuminUrine
1972
THE EFFECT OF AZATHIOPRINE ON LUPUS GLOMERULONEPHRITIS
HAYSLETT J, KASHGARIAN M, COOK C, SPARGO B. THE EFFECT OF AZATHIOPRINE ON LUPUS GLOMERULONEPHRITIS. Medicine 1972, 51: 393. PMID: 4115512, DOI: 10.1097/00005792-197209000-00004.Peer-Reviewed Original Research