1999
Differential regulation of NHE isoforms by sodium depletion in proximal and distal segments of rat colon
Ikuma M, Kashgarian M, Binder H, Rajendran V. Differential regulation of NHE isoforms by sodium depletion in proximal and distal segments of rat colon. American Journal Of Physiology 1999, 276: g539-g549. PMID: 9950829, DOI: 10.1152/ajpgi.1999.276.2.g539.Peer-Reviewed Original ResearchConceptsDietary sodium depletionSodium depletionDistal colonRat colonProtein expressionMRNA abundanceBlot analysisDose-dependent inhibitorApical membrane vesiclesElectroneutral NaCl absorptionWestern blot analysisDifferential regulationNormal ratsProximal colonHOE 694Multiple diverse effectsColonDistal segmentsNaCl absorptionNHE isoformsExchange activityExchanger isoformsNorthern blot analysisDifferential effectsPretranslational level
1998
Antibodies against mesangial cells and their secretory products in chronic renal allograft rejection in the rat.
Paul L, Muralidharan J, Muzaffar S, Manting E, Valentin J, de Heer E, Kashgarian M. Antibodies against mesangial cells and their secretory products in chronic renal allograft rejection in the rat. American Journal Of Pathology 1998, 152: 1209-23. PMID: 9588890, PMCID: PMC1858589.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesAutoantigensBasement MembraneBiglycanBlotting, WesternCells, CulturedChronic DiseaseDecorinEndothelium, VascularExtracellular Matrix ProteinsFlow CytometryFluorescent Antibody Technique, IndirectGlomerular MesangiumGraft RejectionKidney TransplantationMaleProteoglycansRatsRats, Inbred F344Rats, Inbred LewTransplantation, HomologousConceptsMesangial cell culture supernatantsChronic renal allograft rejectionRenal allograft rejectionMesangial cellsChronic rejectionAllograft rejectionCell culture supernatantsChronic renal transplant rejectionFlow cytometryWestern blotEndothelial cellsGlomerular basement membrane antigenPost-transplant seraRenal transplant rejectionCell-mediated immunityPost-immunization seraPresence of antibodiesMesangial cell surfaceStrong autoantibody responseCulture supernatantsCultured mesangial cellsIndirect immunofluorescent studiesBasement membrane antigensIndirect immunofluorescent stainingTissue repair process
1997
Regulation of colonic H-K-ATPase in large intestine and kidney by dietary Na depletion and dietary K depletion
Sangan P, Rajendran V, Mann A, Kashgarian M, Binder H. Regulation of colonic H-K-ATPase in large intestine and kidney by dietary Na depletion and dietary K depletion. American Journal Of Physiology 1997, 272: c685-c696. PMID: 9124313, DOI: 10.1152/ajpcell.1997.272.2.c685.Peer-Reviewed Original ResearchConceptsDietary K depletionDistal colonNA depletionK-ATPase activityProximal colonLarge intestineRat distal colonActive K absorptionK-ATPaseRenal collecting ductsDietary NaK-ATPase expressionK-ATPase isoformsK depletionRat colonCollecting ductsOuter medullaColonProtein expressionProtein levelsKidneyPolyclonal antibodiesIntestineDuctMRNA
1994
Expression and molecular regulation of Na(+)-K(+)-ATPase after renal ischemia
Van Why S, Mann A, Ardito T, Siegel N, Kashgarian M. Expression and molecular regulation of Na(+)-K(+)-ATPase after renal ischemia. American Journal Of Physiology 1994, 267: f75-f85. PMID: 8048568, DOI: 10.1152/ajprenal.1994.267.1.f75.Peer-Reviewed Original Research
1992
Induction and intracellular localization of HSP-72 after renal ischemia
Van Why S, Hildebrandt F, Ardito T, Mann A, Siegel N, Kashgarian M. Induction and intracellular localization of HSP-72 after renal ischemia. American Journal Of Physiology 1992, 263: f769-f775. PMID: 1443167, DOI: 10.1152/ajprenal.1992.263.5.f769.Peer-Reviewed Original ResearchConceptsHSP 72Renal ischemiaHeat shock proteinsIschemic renal injuryMin of reperfusionProtein elaborationHSP mRNA expressionHSP-70 mRNARenal injuryIschemic injuryTransient ischemiaProximal tubulesIschemiaRat kidneyMRNA expressionIntracellular localizationMRNA inductionInjuryTubule morphologyImmunofluorescent localizationShock proteinsVesicular patternCellular recoveryHSP proteinsCellular remodeling