1994
The benefit of early treatment with immunosuppressive agents in lupus nephritis.
Esdaile J, Joseph L, MacKenzie T, Kashgarian M, Hayslett J. The benefit of early treatment with immunosuppressive agents in lupus nephritis. The Journal Of Rheumatology 1994, 21: 2046-51. PMID: 7869308.Peer-Reviewed Original ResearchConceptsHour urinary protein excretionUrinary protein excretionLead-time biasRenal biopsyLupus nephritisRenal insufficiencyRenal involvementSerum creatinineProtein excretionImmunosuppressive agentsEarly treatmentHigh-dose prednisoneLupus renal involvementSubsequent renal insufficiencyTime biasFirst renal biopsySelection biasDose prednisoneTubulointerstitial indexRenal diseaseLongterm prognosisImmunosuppressive drugsEffect of durationBiopsySignificant associationThe Time‐Dependence of Long‐Term Prediction in Lupus Nephritis
Esdaile J, Abrahamowicz M, Mackenzie T, Hayslett J, Kashgarian M. The Time‐Dependence of Long‐Term Prediction in Lupus Nephritis. Arthritis & Rheumatism 1994, 37: 359-368. PMID: 8129791, DOI: 10.1002/art.1780370309.Peer-Reviewed Original ResearchConceptsDisease activity measuresLupus nephritisRenal failureActivity measuresLupus nephritis patientsRenal failure outcomeObservation periodCox model analysisLong-term outcomesMean followup timeGood prognostic markerNonrenal outcomesTubulointerstitial indexChronicity indexNephritis patientsRenal outcomesExtended observation periodRenal involvementComorbid diseasesPrognostic factorsRenal functionDevelopment of diseaseRenal biopsyFollowup timeLaboratory predictors
1993
The pathogenesis and prognosis of lupus nephritis: Information from repeat renal biopsy
Esdaile J, Joseph L, MacKenzie T, Kashgarian M, Hayslett J. The pathogenesis and prognosis of lupus nephritis: Information from repeat renal biopsy. Seminars In Arthritis And Rheumatism 1993, 23: 135-148. PMID: 8266110, DOI: 10.1016/s0049-0172(05)80019-8.Peer-Reviewed Original ResearchConceptsSecond biopsySubendothelial depositsLupus nephritisRenal biopsySubepithelial depositsDiffuse proliferative nephritisHealth activity indexRepeat renal biopsyActivity index scoreSerum creatinine levelsUrinary protein excretionImmune complex depositionLong-term outcomesPathogenesis of lupusChronicity indexTubulointerstitial indexRenal impairmentRenal insufficiencyCreatinine levelsInception cohortRenal functionProtein excretionComplex depositionMesangial hypercellularityMembranous pattern