1998
Heat-shock protein 25 induction and redistribution during actin reorganization after renal ischemia
Aufricht C, Ardito T, Thulin G, Kashgarian M, Siegel N, Van Why S. Heat-shock protein 25 induction and redistribution during actin reorganization after renal ischemia. American Journal Of Physiology 1998, 274: f215-f222. PMID: 9458842, DOI: 10.1152/ajprenal.1998.274.1.f215.Peer-Reviewed Original ResearchConceptsHSP-25Renal ischemiaHeat shock protein 25Ischemic renal injuryH reflowRat renal cortexControl proximal tubulesRenal injuryPostischemic recoveryRenal cortexIschemiaProximal tubulesIntracytoplasmic accumulationPeak levelsHeat shock proteinsProtein 25Actin stainingInsoluble cytoskeletal fractionPunctate accumulationsCytoskeletal disruptionSmall heat shock proteinsRegulatory roleInductionIntracellular distributionCytoskeletal fraction
1992
Induction and intracellular localization of HSP-72 after renal ischemia
Van Why S, Hildebrandt F, Ardito T, Mann A, Siegel N, Kashgarian M. Induction and intracellular localization of HSP-72 after renal ischemia. American Journal Of Physiology 1992, 263: f769-f775. PMID: 1443167, DOI: 10.1152/ajprenal.1992.263.5.f769.Peer-Reviewed Original ResearchConceptsHSP 72Renal ischemiaHeat shock proteinsIschemic renal injuryMin of reperfusionProtein elaborationHSP mRNA expressionHSP-70 mRNARenal injuryIschemic injuryTransient ischemiaProximal tubulesIschemiaRat kidneyMRNA expressionIntracellular localizationMRNA inductionInjuryTubule morphologyImmunofluorescent localizationShock proteinsVesicular patternCellular recoveryHSP proteinsCellular remodeling
1989
Metabolic alterations in proximal tubule suspensions obtained from ischemic kidneys
Gaudio K, Thulin G, Ardito T, Kashgarian M, Siegel N. Metabolic alterations in proximal tubule suspensions obtained from ischemic kidneys. American Journal Of Physiology 1989, 257: f383-f389. PMID: 2551186, DOI: 10.1152/ajprenal.1989.257.3.f383.Peer-Reviewed Original ResearchConceptsProximal tubule suspensionsIschemic injuryTubule suspensionsRenal artery ischemiaVivo ischemic injurySprague-Dawley ratsMin of reflowOxygen consumptionPresence of ouabainBasal O2 consumptionArtery ischemiaIschemic kidneyHistopathological appearanceMetabolic alterationsProximal tubulesControl levelsProtein 1
1979
A micropuncture study of the renal handling of lithium
Hayslett J, Kashgarian M. A micropuncture study of the renal handling of lithium. Pflügers Archiv - European Journal Of Physiology 1979, 380: 159-163. PMID: 573443, DOI: 10.1007/bf00582152.Peer-Reviewed Original ResearchConceptsMicropuncture studiesProximal tubulesLoop of HenleTubular fluid samplesNephron sitesNet transepithelial movementRenal handlingLithium reabsorptionDistal tubulesClearance studiesTubular fluidProximal convolutionExperimental animalsDistal portionFluid samplesTubulesTransepithelial movementHenleNephron
1978
Effects of potassium depletion on renal tubular chloride transport in the rat
Luke R, Wright F, Fowler N, Kashgarian M, Giebisch G. Effects of potassium depletion on renal tubular chloride transport in the rat. Kidney International 1978, 14: 414-427. PMID: 35645, DOI: 10.1038/ki.1978.146.Peer-Reviewed Original ResearchConceptsEarly distal tubuleLoop of HenleDistal tubulesKD groupChloride reabsorptionProximal tubulesPotassium depletionAbsolute chloride reabsorptionAdministration of DOCASingle nephron GFRRenal tubular reabsorptionPotassium-depleted ratsLate distal tubuleEffects of KDNephron GFRTubular reabsorptionChloride intakeFractional reabsorptionClearance studiesDay 2Fractional deliveryMuscle potassiumWhole kidneyDay 9RatsMicropuncture study on the effects of lithium on proximal and distal tubule function in the rat kiney
Hecht B, Kashgarian M, Forrest J, Hayslett J. Micropuncture study on the effects of lithium on proximal and distal tubule function in the rat kiney. Pflügers Archiv - European Journal Of Physiology 1978, 377: 69-74. PMID: 569282, DOI: 10.1007/bf00584376.Peer-Reviewed Original ResearchConceptsFractional reabsorptionDistal tubule functionProximal fractional reabsorptionPlasma lithium concentrationReabsorption of bicarbonateMultiple nephron segmentsEnd-proximal tubuleEffects of lithiumLithium treatmentPotassium secretionAntidiuretic hormoneDistal tubulesMicropuncture studiesTubule functionProximal tubulesDistal convolutionExperimental animalsNephron segmentsReabsorptionDistal portionTubulesPrevious studiesRatsSodiumHormone
1971
Accelerated reabsorption in the proximal tubule produced by volume depletion
Weiner M, Weinman E, Kashgarian M, Hayslett J. Accelerated reabsorption in the proximal tubule produced by volume depletion. Journal Of Clinical Investigation 1971, 50: 1379-1385. PMID: 5090054, PMCID: PMC292075, DOI: 10.1172/jci106620.Peer-Reviewed Original ResearchConceptsProximal tubulesFiltration rateVolume depletionIntrinsic reabsorptive capacitySodium-free dietGlomerular filtration rateProximal fluid reabsorptionAdministration of furosemideReabsorption of fluidTechnique of micropunctureAldosterone secretionRenal responseSodium depletionDistal tubulesReabsorptive capacityBody weightChronic depletionFluid reabsorptionMarked fallExtracellular volumePlasma volumeClinical phenomenaReabsorptionTubulesPresent experiments
1970
Effects of Chloride Restriction and Depletion on Acid-Base Balance and Chloride Conservation in the Rat
Luke R, Warren Y, Kashgarian M, Levitin H. Effects of Chloride Restriction and Depletion on Acid-Base Balance and Chloride Conservation in the Rat. Clinical Science 1970, 38: 385-396. PMID: 5442558, DOI: 10.1042/cs0380385.Peer-Reviewed Original ResearchConceptsUrinary net acid excretionNet acid excretionAcid excretionPlasma bicarbonateProximal tubulesBicarbonate absorptionDietary chloride restrictionProximal tubular absorptionUrinary acid excretionEndogenous acid productionLow chloride dietDegree of elevationAcid-base balanceDietary sodiumPlasma chlorideSerum bicarbonateTubular absorptionPhosphate excretionRespiratory acidosisMicropuncture experimentsDepleted ratsHypochloraemiaRatsExcretionRates of sodiumMicropuncture Studies of Chloride and Bicarbonate Absorption in the Proximal Renal Tubule of the Rat in Respiratory Acidosis and in Chloride Depletion
Warren Y, Luke R, Kashgarian M, Levitin H. Micropuncture Studies of Chloride and Bicarbonate Absorption in the Proximal Renal Tubule of the Rat in Respiratory Acidosis and in Chloride Depletion. Clinical Science 1970, 38: 375-383. PMID: 5442557, DOI: 10.1042/cs0380375.Peer-Reviewed Original ResearchConceptsProximal tubulesBicarbonate absorptionRespiratory acidosisMicropuncture studiesPlasma bicarbonateProximal tubular absorptionUrinary acid excretionUrinary chloride excretionLow chloride dietSignificant increaseProximal renal tubulesSodium restrictionHr of exposureTubular absorptionChloride excretionAcid excretionRenal tubulesChloride absorptionHr exposureReciprocal patternDistal sitesTubulesAcidosisExcretionChloride depletion
1968
Functional correlates of compensatory renal hypertrophy
Hayslett J, Kashgarian M, Epstein F. Functional correlates of compensatory renal hypertrophy. Journal Of Clinical Investigation 1968, 47: 774-782. PMID: 5641618, PMCID: PMC297228, DOI: 10.1172/jci105772.Peer-Reviewed Original Research
1967
Changes in Proximal and Distal Tubular Reabsorption Produced by Rapid Expansion of Extracellular Fluid*
Hayslett J, Kashgarian M, Epstein F. Changes in Proximal and Distal Tubular Reabsorption Produced by Rapid Expansion of Extracellular Fluid*. Journal Of Clinical Investigation 1967, 46: 1254-1263. PMID: 6027087, PMCID: PMC297124, DOI: 10.1172/jci105618.Peer-Reviewed Original ResearchConceptsTubular reabsorptionTubular diameterDistal tubular reabsorptionGlomerular filtration rateProximal tubular reabsorptionAdministration of aldosteroneLoop of HenleAcute infusionFiltration rateRenal contentSaline infusionGlomerular filtrationSegments of tubulesIsotonic salineProximal tubulesExcretion of saltTubular flowReabsorptionExtracellular fluidInfusionTubulesInterstitial volumeRatsTransit timeAldosterone
1965
Micropuncture study of proximal renal tubular chloride transport during hypercapnea in the rat
Kashgarian M, Warren Y, Levitin H. Micropuncture study of proximal renal tubular chloride transport during hypercapnea in the rat. American Journal Of Physiology 1965, 209: 655-658. PMID: 5837751, DOI: 10.1152/ajplegacy.1965.209.3.655.Peer-Reviewed Original Research