1981
Steroid-dependent nephrotic syndrome in children: Histopathology and relapses after cyclophosphamide treatment
Siegel N, Gaudio K, Krassner L, McDonald B, Anderson F, Kashgarian M. Steroid-dependent nephrotic syndrome in children: Histopathology and relapses after cyclophosphamide treatment. Kidney International 1981, 19: 454-459. PMID: 7241883, DOI: 10.1038/ki.1981.39.Peer-Reviewed Original ResearchConceptsMinimal change lesionSteroid-dependent nephrotic syndromeIncidence of relapseNephrotic syndromeMesangial proliferationSegmental glomerulosclerosisCyclophosphamide treatmentYears of followupTime of treatmentSustained remissionComplete remissionMore relapsesClinical courseHistologic typeHistopathologic typeCyclophosphamidePatientsBiopsy samplesRelapseLesionsSyndromeGlomerulosclerosisRemissionChildrenTreatment
1977
SEQUENTIAL HISTOLOGIC CHANGES IN UNTREATED MESANGIALCAPILLARY GLOMERULONEPHRITIS (MCGN)
Siegel N, Kashgarian M. SEQUENTIAL HISTOLOGIC CHANGES IN UNTREATED MESANGIALCAPILLARY GLOMERULONEPHRITIS (MCGN). Pediatric Research 1977, 11: 557-557. DOI: 10.1203/00006450-197704000-01126.Peer-Reviewed Original ResearchInterstitial fibrosisMesangial sclerosisSubendothelial depositsSecond renal biopsyDiffuse mesangial proliferationHistologic improvementSteroid therapyImmunosuppressive agentsRenal biopsyInitial diagnosisMesangial proliferationPatientsSubepithelial depositsSequential histologicSclerosisBasement membraneFibrosisRecent dataSignificant changesProliferationProgressive changesGlomerulonephritisBiopsyHistologicTherapy
1975
Diffuse glomerulonephritis in rabbits with Streptococcus viridans endocarditis.
Arnold S, Valone J, Askenase P, Kashgarian M, Freedman L. Diffuse glomerulonephritis in rabbits with Streptococcus viridans endocarditis. Laboratory Investigation 1975, 32: 681-9. PMID: 125360.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialComplement C3Disease Models, AnimalEndocarditis, BacterialFluorescent Antibody TechniqueGlomerulonephritisHistological TechniquesImmune Complex DiseasesImmunizationImmunoglobulin GKidneyMaleMicroscopy, ElectronMicroscopy, FluorescenceRabbitsRheumatoid FactorSplenomegalyStreptococcal InfectionsConceptsInfective endocarditisDiffuse glomerulonephritisSubendothelial electron-dense depositsStreptococcus viridans endocarditisDeposition of IgGDiffuse proliferative glomerulonephritisSerum complement levelsAcute diffuse proliferative glomerulonephritisPositive blood culturesElectron microscopic findingsElectron-dense depositsComplement levelsGlomerular changesValvular vegetationsRheumatoid factorLeukocytic infiltrationMesangial proliferationProliferative glomerulonephritisBlood culturesImmune mechanismsCapillary occlusionMorphologic findingsIntravenous administrationMicroscopic findingsEndocarditis