1988
Beneficial effect of thyroxin in the treatment of ischemic acute renal failure
Sutter P, Thulin G, Stromski M, Ardito T, Gaudio K, Kashgarian M, Siegel N. Beneficial effect of thyroxin in the treatment of ischemic acute renal failure. Pediatric Nephrology 1988, 2: 1-7. PMID: 2856365, DOI: 10.1007/bf00870370.Peer-Reviewed Original ResearchConceptsAcute renal failureIschemic acute renal failureRenal failureIschemic controlsNormal salineSaline-treated ischemic controlsBeneficial effectsBetter kidney functionDose of T4Min of reflowT4-treated ratsEffect of thyroxinRenal functionKidney functionNS animalsRenal ischemiaInulin clearanceSaline controlsDay 3Day 7IschemiaT4 animalsRenal ATPCellular mechanismsSignificant increase
1986
Postischemic hemodynamics and recovery of renal adenosine triphosphate
Gaudio K, Stromski M, Thulin G, Ardito T, Kashgarian M, Siegel N. Postischemic hemodynamics and recovery of renal adenosine triphosphate. American Journal Of Physiology 1986, 251: f603-f609. PMID: 3490185, DOI: 10.1152/ajprenal.1986.251.4.f603.Peer-Reviewed Original ResearchConceptsRenal blood flowIschemic acute renal injuryImportant pathophysiological componentRenal ATP levelsAcute renal injuryInfusion of dopamineSaline-treated ratsPostischemic enhancementRenal adenosineRenal vasoconstrictionRenal injuryTubular functionPathophysiological componentPostischemic infusionInulin clearanceATP-MgCl2Vasoactive compoundsTubular epitheliumBlood flowPharmacological agentsPostischemic hemodynamicsTubular cellsSaline ratsEnhances recoveryRats
1984
HEMODYNAMIC EFFECT OF POST-ISCHEMIC ATP-MGCL2
Gaudio K, Thulin G, Kashgarian M, Siegel N. HEMODYNAMIC EFFECT OF POST-ISCHEMIC ATP-MGCL2. Pediatric Research 1984, 18: 362-362. DOI: 10.1203/00006450-198404001-01613.Peer-Reviewed Original ResearchRenal blood flowHemodynamic effectsATP-MgCl2Normal salineBlood flowInitial hemodynamic effectsAcute renal failureInfusion of dopamineRenal failureRenal ischemiaPostischemic infusionInulin clearanceVasoactive compoundsTubular cellsSalutary effectsCINInfusionHrDopamineCellular metabolismIschemiaInjuryRatsSalineClearance
1983
Role of angiotensin II-induced renal functional changes in mesangial deposition of exogenous ferritin in rats.
Stein H, Feddergreen W, Kashgarian M, Sterzel R. Role of angiotensin II-induced renal functional changes in mesangial deposition of exogenous ferritin in rats. Laboratory Investigation 1983, 49: 270-80. PMID: 6350702.Peer-Reviewed Original ResearchConceptsBlood pressureFiltration fractionMesangial localizationAngiotensin IIFunctional changesAcute angiotensin IIAminohippuric acid clearanceRenal functional changesSystolic blood pressureExcretion of albuminSingle intravenous doseGlomerular capillary permeabilityGroups of ratsInjection of ferritinPressor doseAcid clearanceIntravenous doseMesangial depositionMesangial accumulationFerritin concentrationInulin clearanceTreatment periodRenal tissueSerial measurementsFerritin deposition
1982
Accelerated recovery of single nephron function by the postischemic infusion of ATP-MgCl2
Gaudio K, Taylor M, Chaudry I, Kashgarian M, Siegel N. Accelerated recovery of single nephron function by the postischemic infusion of ATP-MgCl2. Kidney International 1982, 22: 13-20. PMID: 7120752, DOI: 10.1038/ki.1982.126.Peer-Reviewed Original ResearchConceptsClearance of inulinSingle nephron functionATP-MgCl2Proximal tubular pressureNephron functionTubular pressureBeneficial effectsRenal artery ischemiaSaline-treated animalsSaline-treated ratsCourse of recoveryGroups of animalsPostischemic administrationArtery ischemiaPattern of recoveryCIN 1Postischemic infusionInitial insultInulin clearanceInitial improvementControl animalsMost epithelial cellsEnhanced recoveryWhole kidneyTubular fluid
1980
ISCHEMIC ACUTE RENAL FAILURE: DELAYED INFUSION OF ATP-MGCL2
Siegel N, Taylor M, Gaudio K, Chaudry I, Kashgarian M. ISCHEMIC ACUTE RENAL FAILURE: DELAYED INFUSION OF ATP-MGCL2. Pediatric Research 1980, 14: 1017-1017. DOI: 10.1203/00006450-198008000-00262.Peer-Reviewed Original ResearchMinutes of ischemiaATP-MgCl2Normal salineIschemic insultBilateral renal artery occlusionModerate ischemic insultRenal artery occlusionInfusion of ATPDelayed infusionRenal injuryArtery occlusionIschemic injuryRenal ischemiaInitial injuryInitial insultInulin clearanceInjuryIschemiaInfusionInsultCINAnimalsMinutesHoursPrevious studies
1977
Renal function and cortical blood flow during the recovery phase of acute renal failure
Siegel N, Gunstream S, Handler R, Kashgarian M. Renal function and cortical blood flow during the recovery phase of acute renal failure. Kidney International 1977, 12: 199-204. PMID: 926611, DOI: 10.1038/ki.1977.101.Peer-Reviewed Original ResearchConceptsTotal renal blood flowGlomerular filtration rateAcute renal failureCortical blood flowRenal failureRenal functionBlood flowSham-injected control animalsOuter cortexOuter cortical perfusionRenal blood flowRecovery phaseCortical perfusionTubular functionSignificant diuresisFiltration rateInulin clearanceControl animalsDay 4Control valuesAbsolute perfusionProgressive improvementCortexEarly recovery phaseParallel increase