1987
Response of collecting tubule cells to aldosterone and potassium loading
Kashgarian M, Ardito T, Hirsch D, Hayslett J. Response of collecting tubule cells to aldosterone and potassium loading. American Journal Of Physiology 1987, 253: f8-f14. PMID: 3605352, DOI: 10.1152/ajprenal.1987.253.1.f8.Peer-Reviewed Original ResearchConceptsInitial collecting tubuleCortical collecting tubuleBasolateral membrane surfaceCollecting tubuleChronic potassium loadingElevated levelsDuct structuresPotassium loadingSite of actionPlasma levelsRat modelOuter stripeInner stripeTubule cellsNormal physiological levelsControl valuesAldoMorphometric studyAldosteronePhysiological levelsDuct systemTubulesConcomitant changesDuct
1984
Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule
Hirsch D, Kashgarian M, Boulpaep E, Hayslett J. Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule. Kidney International 1984, 26: 798-807. PMID: 6099857, DOI: 10.1038/ki.1984.221.Peer-Reviewed Original ResearchConceptsInitial collecting tubuleCollecting tubuleDistal convolutionAldosterone levelsPotassium adaptationChronic potassium loadingMineralocorticoid-sensitive tissuesRole of aldosteronePlasma aldosterone levelsAction of aldosteroneIntact adrenal glandsPotassium loadingPhysiological plasma levelsChronic hyperaldosteronismTransepithelial potential differenceChronic administrationEpithelial changesAdrenal glandPlasma levelsDietary potassium loadingBasal valuesAldosteroneTubule cellsNephron segmentsTarget tissues