2008
A Novel Form of Human Mendelian Hypertension Featuring Nonglucocorticoid-Remediable Aldosteronism
Geller DS, Zhang J, Wisgerhof MV, Shackleton C, Kashgarian M, Lifton RP. A Novel Form of Human Mendelian Hypertension Featuring Nonglucocorticoid-Remediable Aldosteronism. The Journal Of Clinical Endocrinology & Metabolism 2008, 93: 3117-3123. PMID: 18505761, PMCID: PMC2515083, DOI: 10.1210/jc.2008-0594.Peer-Reviewed Original ResearchConceptsGlucocorticoid-remediable aldosteronismAdrenal fasciculataAdministration of dexamethasoneAdrenal steroid productionAdrenal steroid biosynthesisNew familial formAge 7 yrSecondary hypertensionBilateral adrenalectomyMost patientsPrimary aldosteronismAdrenal weightClinical syndromeAdrenal glandCortisol secretionLeading causeAldosteronismHypertensionMedical treatmentAldosterone synthaseSteroid productionAutosomal dominant formCellular hypertrophyCortical compartmentFamilial forms
1985
Pathology of Small Blood Vessel Disease in Hypertension
Kashgarian M. Pathology of Small Blood Vessel Disease in Hypertension. American Journal Of Kidney Diseases 1985, 5: a104-a110. PMID: 2581443, DOI: 10.1016/s0272-6386(85)80072-x.Peer-Reviewed Original ResearchConceptsHyaline arteriolosclerosisPerpetuation of hypertensionSmall blood vessel diseaseBlood vessel diseasesArteriolar diseaseMyointimal hyperplasiaVessel diseasePathogenic rolePathophysiologic consequencesAnatomic correlatesHypertensionTransmural pressureArteriolosclerosisLesionsDiseaseExtracellular matrixArteriolonecrosisHyperplasiaArteriolesPathogenesisTherapyPathology