Parathyroid hormone directly inhibits tubular reabsorption of bicarbonate in normocalcaemic rats with chronic hyperparathyroidism
JAEGER P, JONES W, KASHGARIAN M, SEGRE G, HAYSLETT J. Parathyroid hormone directly inhibits tubular reabsorption of bicarbonate in normocalcaemic rats with chronic hyperparathyroidism. European Journal Of Clinical Investigation 1987, 17: 415-420. PMID: 3121345, DOI: 10.1111/j.1365-2362.1987.tb01136.x.Peer-Reviewed Original ResearchConceptsParathyroid hormonePTH infusionChronic hyperparathyroidismPlasma calciumAnimal modelsEffect of PTHProximal HCO3 reabsorptionChronic metabolic acidosisGroups of animalsPrimary hyperparathyroidismAlzet minipumpsSerum calciumTubular reabsorptionAcute studyMetabolic acidosisMetabolic alkalosisRenal handlingTubular acidificationAcid secretionGroup IIHCO3- reabsorptionFree dietHyperparathyroidismCa-free dietNormal levelsAnimal model of primary hyperparathyroidism
Jaeger P, Jones W, Kashgarian M, Baron R, Clemens T, Segre G, Hayslett J. Animal model of primary hyperparathyroidism. American Journal Of Physiology 1987, 252: e790-e798. PMID: 3591940, DOI: 10.1152/ajpendo.1987.252.6.e790.Peer-Reviewed Original ResearchConceptsTheoretical renal thresholdPrimary hyperparathyroidismPlasma levelsRenal thresholdAnimal modelsD plasma levelsPTH plasma levelsPlasma calcium levelsSynthetic parathyroid hormonePTH levelsDihydroxyvitamin DParathyroid hormoneParathyroidectomized animalsBovine PTHChronic hyperparathyroidismSustained elevationNormal limitsPlasma calciumHyperparathyroidismCalcium levelsOrgan systemsEpithelial functionControl valuesBasal levelsExperimental model