1981
Steroid-dependent nephrotic syndrome in children: Histopathology and relapses after cyclophosphamide treatment
Siegel N, Gaudio K, Krassner L, McDonald B, Anderson F, Kashgarian M. Steroid-dependent nephrotic syndrome in children: Histopathology and relapses after cyclophosphamide treatment. Kidney International 1981, 19: 454-459. PMID: 7241883, DOI: 10.1038/ki.1981.39.Peer-Reviewed Original ResearchConceptsMinimal change lesionSteroid-dependent nephrotic syndromeIncidence of relapseNephrotic syndromeMesangial proliferationSegmental glomerulosclerosisCyclophosphamide treatmentYears of followupTime of treatmentSustained remissionComplete remissionMore relapsesClinical courseHistologic typeHistopathologic typeCyclophosphamidePatientsBiopsy samplesRelapseLesionsSyndromeGlomerulosclerosisRemissionChildrenTreatment
1975
Minimal-lesion nephrotic syndrome with early resistance to steroid therapy
Siegel N, Gur A, Krassner L, Kashgarian M. Minimal-lesion nephrotic syndrome with early resistance to steroid therapy. The Journal Of Pediatrics 1975, 87: 377-380. PMID: 1165516, DOI: 10.1016/s0022-3476(75)80639-1.Peer-Reviewed Original ResearchConceptsMinimal lesion nephrotic syndromeNephrotic syndromeLong-term clinical courseEarly resistanceMinimal glomerular lesionsClinical courseSteroid responsivenessClinical outcomesPrompt remissionCyclophosphamide treatmentGlomerular lesionsHistopathologic lesionsPatientsRemissionCyclophosphamideSyndromeTherapyLesionsUltimate outcomeOutcomesChildrenCorticosteroidsPrednisoneRelapseSteroidsClinical Aspects of Bilateral Renal Dysplasia in Children
Gur A, Siegel N, Davis C, Kashgarian M, Hayslett J. Clinical Aspects of Bilateral Renal Dysplasia in Children. Nephron 1975, 15: 50-61. PMID: 236522, DOI: 10.1159/000180492.Peer-Reviewed Original ResearchConceptsBilateral renal dysplasiaRenal dysplasiaClinical featuresClinical aspectsProgressive renal deteriorationLong-term prognosisRenal deteriorationBilateral involvementClinical courseUrinary concentrationsLaurence-MoonBiedl syndromePathogenic mechanismsDysplasiaPaucity of informationPatientsChildrenLarge proportionPrognosisSyndromeImpairment
1974
CYCLOPHOSPHAMIDE IN THE TREATMENT OF STEROID-RESISTANT MINIMAL-CHANGE NEPHROTIC SYNDROME
Siegel N, Gur A, Krassner L, Kashgarian M, Cook C. CYCLOPHOSPHAMIDE IN THE TREATMENT OF STEROID-RESISTANT MINIMAL-CHANGE NEPHROTIC SYNDROME. Pediatric Research 1974, 8: 461-461. DOI: 10.1203/00006450-197404000-00724.Peer-Reviewed Original ResearchNephrotic syndromeComplete remissionSteroid-resistant minimal change nephrotic syndromeMinimal change nephrotic syndromeSteroid-resistant nephrotic syndromeCourses of cyclophosphamideMinimal change lesionChange nephrotic syndromeTreatment of childrenSteroid therapyGonadal toxicityInitial treatmentSuch therapyCyclophosphamideWeek courseSyndromeLittle dataPrednisoneRemissionTreatmentPatientsChildrenTherapyGlucosteroidsRelapseMinimal Change and Focal Sclerotic Lesions in Lipoid Nephrosis
Siegel N, Kashgarian M, Spargo B, Hayslett J. Minimal Change and Focal Sclerotic Lesions in Lipoid Nephrosis. Nephron 1974, 13: 125-137. PMID: 4368918, DOI: 10.1159/000180385.Peer-Reviewed Original ResearchConceptsSteroid-sensitive diseaseFocal sclerotic lesionsNephrotic syndromeSclerotic lesionsMinimal change lesionCourse of diseaseMinimal glomerular changesYears of ageLipoid nephrosisSteroid resistanceClinicopathological relationshipRenal biopsyGlomerular changesFocal glomerulosclerosisUltrastructural examinationDiseaseLesionsSyndromeChildrenLight microscopyMinimal changesOnsetEarly evidenceYearsBroad spectrum