2009
Gonadotropin inhibitory hormone inhibits basal forebrain vGluT2‐gonadotropin‐releasing hormone neurons via a direct postsynaptic mechanism
Wu M, Dumalska I, Morozova E, Van Den Pol AN, Alreja M. Gonadotropin inhibitory hormone inhibits basal forebrain vGluT2‐gonadotropin‐releasing hormone neurons via a direct postsynaptic mechanism. The Journal Of Physiology 2009, 587: 1401-1411. PMID: 19204051, PMCID: PMC2678216, DOI: 10.1113/jphysiol.2008.166447.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsFemaleGamma-Aminobutyric AcidGlutamate DecarboxylaseGlutamic AcidGlycoproteinsGonadotropin-Releasing HormoneGreen Fluorescent ProteinsImmunohistochemistryMaleMiceMice, TransgenicNeural InhibitionNeuronsNeuropeptidesPatch-Clamp TechniquesPotassiumProsencephalonRecombinant Fusion ProteinsSynaptic PotentialsSynaptic TransmissionTime FactorsVesicular Glutamate Transport Protein 2ConceptsGnIH/RFRPGonadotropin-inhibitory hormoneHormone neuronsGnRH neuronsGonadotropin releaseRFRP-3Inhibitory hormoneGonadotropin-releasing hormone (GnRH) neuronsAvian gonadotropin-inhibitory hormoneDirect postsynaptic mechanismGAD67-GFP miceVesicular glutamate transportersTarget brain regionsGABAergic neuronsGlutamate releasePostsynaptic mechanismsAnterior pituitaryBrain slicesMedian eminenceGlutamate transportersReproductive functionBrain regionsInhibitory actionElectrophysiological recordingsNeurons
2007
Neurokinins robustly activate the majority of septohippocampal cholinergic neurons
Morozova E, Wu M, Dumalska I, Alreja M. Neurokinins robustly activate the majority of septohippocampal cholinergic neurons. European Journal Of Neuroscience 2007, 27: 114-122. PMID: 18184316, DOI: 10.1111/j.1460-9568.2007.05993.x.Peer-Reviewed Original ResearchConceptsSeptohippocampal cholinergic neuronsHippocampal acetylcholine releaseCholinergic neuronsNK3 receptorsHemokinin-1Acetylcholine releaseNK2 receptorsElectrophysiological effectsRat brain slice preparationWhole-cell patch-clamp recordingsMedial septum/diagonal bandDiagonal band neuronsNK3 receptor agonistPost-synaptic mechanismsStress-related affective disordersBrain slice preparationPatch-clamp recordingsEffect of NKCholinergic cellsNK receptorsReceptor agonistSlice preparationDiagonal bandNeurokinin receptorsBrain neurons
2004
Histamine innervation and activation of septohippocampal GABAergic neurones: involvement of local ACh release
Xu C, Michelsen KA, Wu M, Morozova E, Panula P, Alreja M. Histamine innervation and activation of septohippocampal GABAergic neurones: involvement of local ACh release. The Journal Of Physiology 2004, 561: 657-670. PMID: 15486020, PMCID: PMC1665378, DOI: 10.1113/jphysiol.2004.071712.Peer-Reviewed Original ResearchConceptsLocal ACh releaseACh releaseGABAergic neuronesCholinergic neuronesSeptohippocampal cholinergicMedial septum/diagonal bandHistamine-induced activationGABAergic cell typesReceptor-selective antagonistHippocampal theta rhythmIndirect mechanismsConcentration-dependent mannerAtropine methylbromideHippocampal arousalGABAergic functionHistaminergic systemTuberomammillary nucleusCholinergic systemReceptor subtypesDiagonal bandHistamine effectSelective antagonistAlzheimer's diseaseGABAergic nucleusNeurodegenerative disorders