Inflammation, stress and depression: An exploration of ketamine’s therapeutic profile
Johnston J, Greenwald M, Henter I, Kraus C, Mkrtchian A, Clark N, Park L, Gold P, Zarate C, Kadriu B. Inflammation, stress and depression: An exploration of ketamine’s therapeutic profile. Drug Discovery Today 2023, 28: 103518. PMID: 36758932, PMCID: PMC10050119, DOI: 10.1016/j.drudis.2023.103518.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsUnique therapeutic mechanismTherapeutic profileCentral nervous system inflammationHypothalamic pituitary adrenal axisNervous system inflammationRapid-acting antidepressantsTreatment-resistant depressionAnti-inflammatory actionPeripheral inflammatory biomarkersSystem inflammationInflammatory biomarkersProinflammatory stateCytokine suppressionAdrenal axisKynurenine pathwayTherapeutic effectTherapeutic mechanismAnimal modelsInflammationDepressionAntidepressantsKetamineFurther investigationBiomarkers