2017
Psychedelics and reconsolidation of traumatic and appetitive maladaptive memories: focus on cannabinoids and ketamine
Fattore L, Piva A, Zanda M, Fumagalli G, Chiamulera C. Psychedelics and reconsolidation of traumatic and appetitive maladaptive memories: focus on cannabinoids and ketamine. Psychopharmacology 2017, 235: 433-445. PMID: 29178010, DOI: 10.1007/s00213-017-4793-4.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderSubstance use disordersMaladaptive memoriesPsychedelic effectsReconsolidation of maladaptive memoriesAppetitive memory reconsolidationMemory reconsolidationMDMA effectsMemory inhibitionReconsolidation processStress disorderKetamine effectsPsychedelic substancesBiobehavioral processesReconsolidationCannabinoidMDMASubstance effectsMemoryPsychedelicsDisordersKetamineClasses of drugsPotential therapeutic effectsPotential therapeutic use
2016
Methoxetamine, a novel psychoactive substance with serious adverse pharmacological effects
Zanda M, Fadda P, Chiamulera C, Fratta W, Fattore L. Methoxetamine, a novel psychoactive substance with serious adverse pharmacological effects. Behavioural Pharmacology 2016, 27: 489-496. PMID: 27128862, DOI: 10.1097/fbp.0000000000000241.Peer-Reviewed Original ResearchConceptsEffects of methoxetamineN-methyl-d-aspartate receptor antagonistic propertiesPsychoactive substancesReceptor antagonist propertiesOccurrence of adverse effectsAdverse pharmacological effectsDopamine neurotransmissionMesolimbic pathwayAntidepressant activityPreclinical dataPreclinical findingsAntagonistic propertiesLong-term effectsPharmacological effectsStimulatory effectMethoxetamineAdverse effectsKetamineLegal highsResearch chemicalsToxicological effectsPhencyclidineDopamineNeurotransmissionIncreasing number
2014
Analysis of Opioid-Seeking Reinstatement in the Rat
Fattore L, Fadda P, Zanda M, Fratta W. Analysis of Opioid-Seeking Reinstatement in the Rat. Methods In Molecular Biology 2014, 1230: 295-307. PMID: 25293336, DOI: 10.1007/978-1-4939-1708-2_25.Peer-Reviewed Original ResearchConceptsNeurobiological mechanismsAnimal model of relapseReinstatement animal modelRelapse-like behaviorHeroin-seeking behaviorRelapse to heroinVulnerability to relapseModel of relapseNose poke responsesPanel press responseNonhuman primatesReinstatement modelDrug seekingLever pressOperant respondingDrug abstinenceAddiction researchPress responseVulnerability factorsConditioned behaviorReinstatementSubstance useOperant responseAnimal modelsIndividual slips