2022
Increased Voluntary Alcohol Consumption in Mice Lacking GABAB(1) Is Associated With Functional Changes in Hippocampal GABAA Receptors
Floris G, Asuni G, Talani G, Biggio F, Pisu M, Zanda M, Contu L, Maciocco E, Serra M, Follesa P. Increased Voluntary Alcohol Consumption in Mice Lacking GABAB(1) Is Associated With Functional Changes in Hippocampal GABAA Receptors. Frontiers In Behavioral Neuroscience 2022, 16: 893835. PMID: 35755407, PMCID: PMC9218813, DOI: 10.3389/fnbeh.2022.893835.Peer-Reviewed Original ResearchVoluntary alcohol consumptionAssociated with functional changesBlood alcohol concentrationAlcohol consumptionIncrease voluntary alcohol consumptionHippocampal GABA<sub>A</KO miceAlcohol drinking behaviorAlcohol drinkingAlcohol use disorderResponse to alcoholExcessive alcohol drinkingAcute alcohol administrationNeuroactive steroid levelsHippocampal GABAA receptorsAdministration of alcoholSynaptic GABA<sub>A</High blood alcohol concentrationsIncreased alcohol consumptionInvestigate alcohol consumptionNeurosteroid responseHippocampal levelsUse disorderBrain regionsAlcohol administrationHeroin Regulates Orbitofrontal Circular RNAs
Floris G, Gillespie A, Zanda M, Dabrowski K, Sillivan S. Heroin Regulates Orbitofrontal Circular RNAs. International Journal Of Molecular Sciences 2022, 23: 1453. PMID: 35163373, PMCID: PMC8836038, DOI: 10.3390/ijms23031453.Peer-Reviewed Original ResearchConceptsHeroin self-administrationOrbitofrontal cortexOpioid use disorderNeurobiological adaptationsSelf-administrationSelf-administer sucroseChronic heroin exposureRat orbitofrontal cortexOpioid-seeking behaviorTreat opioid use disorderHeroin exposureUse disorderBrain regionsOpioid heroinBehavioral responsesMale ratsFemale ratsHeroinSeeking behaviorDrug overdose deathsRatsOverdose deathsOpioidRNA splice variantsCortex
2021
Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence
Zanda M, Floris G, Daws S. Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence. Scientific Reports 2021, 11: 14825. PMID: 34290298, PMCID: PMC8295307, DOI: 10.1038/s41598-021-94214-4.Peer-Reviewed Original ResearchConceptsDrug cuesDrug seekingIncubation of heroin cravingIncubation of opioid cravingDrug self-administration paradigmLow dose of heroinDrug-associated cuesSelf-administration paradigmDoses of heroinDays of abstinenceDrug-taking patternsDrug intake historyHeroin seekingRate of relapseHeroin cravingAbstinence phaseSelf-administrationOpioid cravingOpioid use disorderPromote relapseAbstinence lengthOpioid seekingUse disorderCompletion of rehabilitation programsIntake history