2024
Psilocybin reduces heroin seeking behavior and modulates inflammatory gene expression in the nucleus accumbens and prefrontal cortex of male rats
Floris G, Dabrowski K, Zanda M, Daws S. Psilocybin reduces heroin seeking behavior and modulates inflammatory gene expression in the nucleus accumbens and prefrontal cortex of male rats. Molecular Psychiatry 2024, 1-16. PMID: 39433903, DOI: 10.1038/s41380-024-02788-y.Peer-Reviewed Original ResearchPrefrontal cortexHeroin seekingHeroin relapseDrug seekingSelf-administrationPrefrontal cortex of male ratsPrefrontal cortex of animalsCortex of male ratsHeroin self-administrationHeroin-seeking behaviorDrug-naive ratsOpioid-seeking behaviorSerotonin 2A receptorEfficacy of psilocybinAlcohol seekingHeroin takingForced abstinenceNucleus accumbensRelapse testRelapse behaviorIL-17AMaladaptive behaviorsPsychedelic compoundsAntagonist ketanserinPsilocybin
2023
MicroRNA-mediated translational pathways are regulated in the orbitofrontal cortex and peripheral blood samples during acute abstinence from heroin self-administration
Zanda M, Saikali L, Morris P, Daws S. MicroRNA-mediated translational pathways are regulated in the orbitofrontal cortex and peripheral blood samples during acute abstinence from heroin self-administration. Advances In Drug And Alcohol Research 2023, 3: 11668. PMID: 38389822, PMCID: PMC10880771, DOI: 10.3389/adar.2023.11668.Peer-Reviewed Original ResearchHeroin self-administrationOrbitofrontal cortexSelf-administrationDays of forced abstinenceRegulating drug-seeking behaviorSucrose self-administrationDrug-seeking behaviorChronic drug exposureAdult male ratsPeripheral blood samplesHeroin infusionsHeroin seekingMolecular neuroadaptationsForced abstinenceAcute abstinenceNeurobiological consequencesOpioid heroinOpioid misuseHeroinMale ratsSelf-administeredSeeking behaviorAbstinenceBlood samplesOpioid exposure
2022
Heroin Regulates Orbitofrontal Circular RNAs
Floris G, Gillespie A, Zanda M, Dabrowski K, Sillivan S. Heroin Regulates Orbitofrontal Circular RNAs. International Journal Of Molecular Sciences 2022, 23: 1453. PMID: 35163373, PMCID: PMC8836038, DOI: 10.3390/ijms23031453.Peer-Reviewed Original ResearchConceptsHeroin self-administrationOrbitofrontal cortexOpioid use disorderNeurobiological adaptationsSelf-administrationSelf-administer sucroseChronic heroin exposureRat orbitofrontal cortexOpioid-seeking behaviorTreat opioid use disorderHeroin exposureUse disorderBrain regionsOpioid heroinBehavioral responsesMale ratsFemale ratsHeroinSeeking behaviorDrug overdose deathsRatsOverdose deathsOpioidRNA splice variantsCortex
2021
Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence
Zanda M, Floris G, Daws S. Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence. Scientific Reports 2021, 11: 14825. PMID: 34290298, PMCID: PMC8295307, DOI: 10.1038/s41598-021-94214-4.Peer-Reviewed Original ResearchConceptsDrug cuesDrug seekingIncubation of heroin cravingIncubation of opioid cravingDrug self-administration paradigmLow dose of heroinDrug-associated cuesSelf-administration paradigmDoses of heroinDays of abstinenceDrug-taking patternsDrug intake historyHeroin seekingRate of relapseHeroin cravingAbstinence phaseSelf-administrationOpioid cravingOpioid use disorderPromote relapseAbstinence lengthOpioid seekingUse disorderCompletion of rehabilitation programsIntake history
2018
Sex and Feeding Status Differently Affect Natural Reward Seeking Behavior in Olfactory Bulbectomized Rats
Ruda-Kucerova J, Zanda M, Amchova P, Fratta W, Fattore L. Sex and Feeding Status Differently Affect Natural Reward Seeking Behavior in Olfactory Bulbectomized Rats. Frontiers In Behavioral Neuroscience 2018, 12: 255. PMID: 30425627, PMCID: PMC6218565, DOI: 10.3389/fnbeh.2018.00255.Peer-Reviewed Original ResearchSchedule of reinforcementPalatable food pelletsOBX ratsOBX lesionOperant respondingSelf-administrationFood pelletsNatural reward-seeking behaviorsIntravenous drug self-administrationSex differencesFood self-administrationDepressive-like phenotypeDrug self-administrationOperant self-administrationReward-seeking behaviorDrug-seeking behaviorRates of comorbidityPotential sex differencesFood restrictionOBX modelFood intakeOlfactory bulbectomyDrug-takingPalatable foodPsychiatric disordersOld and new synthetic cannabinoids: lessons from animal models
Zanda M, Fattore L. Old and new synthetic cannabinoids: lessons from animal models. Drug Metabolism Reviews 2018, 50: 54-64. PMID: 29376443, DOI: 10.1080/03602532.2018.1430824.Peer-Reviewed Original ResearchConceptsSynthetic cannabinoidsCannabinoid agonistsAnimal models of drug addictionConditioned place preference procedureModels of drug addictionPlace preference procedureBrain reward circuitsPositive reinforcing effectsDrug-induced behaviorsSynthetic cannabinoid agonistDelta-9-tetrahydrocannabinolReinstatement modelDrug discriminationReward circuitPreference procedureSelf-administrationAbuse liabilityPsychoactive componentAbuse potentialDrug addictionPsychiatric consequencesBehavioral studiesReinforcing effectsCannabinoidPsychoactive substances
2014
Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms
Amchova P, Kucerova J, Giugliano V, Babinska Z, Zanda M, Scherma M, Dusek L, Fadda P, Micale V, Sulcova A, Fratta W, Fattore L. Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms. Frontiers In Pharmacology 2014, 5: 44. PMID: 24688470, PMCID: PMC3960502, DOI: 10.3389/fphar.2014.00044.Peer-Reviewed Original ResearchCB1 receptor agonist WIN55,212-2Model of depressionAgonist WIN55,212-2OBX ratsAcute pre-treatmentNucleus accumbensBulbectomized ratsSelf-administrationWIN55,212-2CGS 12066BIntravenous drug self-administration procedureRats self-administering methamphetamineDrug self-administration proceduresAnimal models of depressionSubstance use disorder comorbidityAssociated with drug consumptionBrain reward functionEnhanced self-administrationSelf-administer WINSerotonin 5HT1B receptor agonistsSham-operated ratsSelf-administer methamphetamineSelf-administration proceduresDepressive-like ratsDepressive-like state