2023
MicroRNA-mediated translational pathways are regulated in the orbitofrontal cortex and peripheral blood samples during acute abstinence from heroin self-administration
Zanda M, Saikali L, Morris P, Daws S. MicroRNA-mediated translational pathways are regulated in the orbitofrontal cortex and peripheral blood samples during acute abstinence from heroin self-administration. Advances In Drug And Alcohol Research 2023, 3: 11668. PMID: 38389822, PMCID: PMC10880771, DOI: 10.3389/adar.2023.11668.Peer-Reviewed Original ResearchHeroin self-administrationOrbitofrontal cortexSelf-administrationDays of forced abstinenceRegulating drug-seeking behaviorSucrose self-administrationDrug-seeking behaviorChronic drug exposureAdult male ratsPeripheral blood samplesHeroin infusionsHeroin seekingMolecular neuroadaptationsForced abstinenceAcute abstinenceNeurobiological consequencesOpioid heroinOpioid misuseHeroinMale ratsSelf-administeredSeeking behaviorAbstinenceBlood samplesOpioid exposure
2020
Analysis of Opioid-Seeking Behavior Through the Intravenous Self-Administration Reinstatement Model in Rats
Fattore L, Fadda P, Zanda M, Fratta W. Analysis of Opioid-Seeking Behavior Through the Intravenous Self-Administration Reinstatement Model in Rats. Methods In Molecular Biology 2020, 2201: 231-245. PMID: 32975804, DOI: 10.1007/978-1-0716-0884-5_21.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAnalgesics, OpioidAnimalsBehavior ControlBehavior, AddictiveConditioning, OperantCuesDisease Models, AnimalDrug-Seeking BehaviorHeroinInfusions, IntravenousMaleOpioid-Related DisordersRatsRats, Sprague-DawleyRats, WistarReinforcement, PsychologyRewardSelf AdministrationSubstance-Related DisordersConceptsNeurobiological mechanismsAnimal model of relapseExtinction-reinstatement modelHeroin-seeking behaviorReinstatement animal modelRelapse-like behaviorModel of relapseRelapse to heroinVulnerability to relapseNose poke responsesPanel press responseNonhuman primatesReinstatement modelDrug seekingLever pressOperant respondingDrug abstinenceAddiction researchVulnerability factorsPress responseSubstance useOperant responseAnimal modelsIndividual slipsSelf-administered