2024
Psilocybin reduces heroin seeking behavior and modulates inflammatory gene expression in the nucleus accumbens and prefrontal cortex of male rats
Floris G, Dabrowski K, Zanda M, Daws S. Psilocybin reduces heroin seeking behavior and modulates inflammatory gene expression in the nucleus accumbens and prefrontal cortex of male rats. Molecular Psychiatry 2024, 1-16. PMID: 39433903, DOI: 10.1038/s41380-024-02788-y.Peer-Reviewed Original ResearchPrefrontal cortexHeroin seekingHeroin relapseDrug seekingSelf-administrationPrefrontal cortex of male ratsPrefrontal cortex of animalsCortex of male ratsHeroin self-administrationHeroin-seeking behaviorDrug-naive ratsOpioid-seeking behaviorSerotonin 2A receptorEfficacy of psilocybinAlcohol seekingHeroin takingForced abstinenceNucleus accumbensRelapse testRelapse behaviorIL-17AMaladaptive behaviorsPsychedelic compoundsAntagonist ketanserinPsilocybinThe sinking platform test: a novel paradigm to measure persistence in animal models
Floris G, Godar S, Braccagni G, Piras I, Ravens A, Zanda M, Huentelman M, Bortolato M. The sinking platform test: a novel paradigm to measure persistence in animal models. Neuropsychopharmacology 2024, 49: 1373-1382. PMID: 38396257, PMCID: PMC11251282, DOI: 10.1038/s41386-024-01827-0.Peer-Reviewed Original ResearchConceptsChronic administration of fluoxetinePrefrontal cortex of miceWeeks of social isolationAdministration of fluoxetineMeasure persistenceGoal-directed actionsSocially isolated miceMitigate depression riskCortex of micePlatform testVoluntary wheel runningChronic haloperidolPrefrontal cortexTemperamental traitsImipramine treatmentNeurobiological foundationsBehavioral tasksChronic stressChronic administrationImmediate-early genesFailure TrialWheel runningDepression riskAnimal modelsNovel interventions
2017
Methoxetamine affects brain processing involved in emotional response in rats
Zanda M, Fadda P, Antinori S, Di Chio M, Fratta W, Chiamulera C, Fattore L. Methoxetamine affects brain processing involved in emotional response in rats. British Journal Of Pharmacology 2017, 174: 3333-3345. PMID: 28718892, PMCID: PMC5595753, DOI: 10.1111/bph.13952.Peer-Reviewed Original ResearchConceptsBehaviorally active dosesDecreased social interaction timeMotor activityMedial prefrontal cortexObsessive-compulsive traitsReduced immobility timeSocial interaction timeSelf-grooming behaviorIncreased phosphorylation of ribosomal protein S6Antidepressant effectsImmobility timePrefrontal cortexBehavioral effectsIncreased sociabilitySpatial anxietyAcute administrationBrain processesHigh dosesIncreased swimming activityEmotional responsesDissociative effectsEmotional statesIntermediate dosePsychoactive substancesMethoxetamine