Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms
Amchova P, Kucerova J, Giugliano V, Babinska Z, Zanda M, Scherma M, Dusek L, Fadda P, Micale V, Sulcova A, Fratta W, Fattore L. Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms. Frontiers In Pharmacology 2014, 5: 44. PMID: 24688470, PMCID: PMC3960502, DOI: 10.3389/fphar.2014.00044.Peer-Reviewed Original ResearchCB1 receptor agonist WIN55,212-2Model of depressionAgonist WIN55,212-2OBX ratsAcute pre-treatmentNucleus accumbensBulbectomized ratsSelf-administrationWIN55,212-2CGS 12066BIntravenous drug self-administration procedureRats self-administering methamphetamineDrug self-administration proceduresAnimal models of depressionSubstance use disorder comorbidityAssociated with drug consumptionBrain reward functionEnhanced self-administrationSelf-administer WINSerotonin 5HT1B receptor agonistsSham-operated ratsSelf-administer methamphetamineSelf-administration proceduresDepressive-like ratsDepressive-like state