2010
Matrix-Specific Protein Kinase A Signaling Regulates p21-Activated Kinase Activation by Flow in Endothelial Cells
Funk SD, Yurdagul A, Green JM, Jhaveri KA, Schwartz MA, Orr AW. Matrix-Specific Protein Kinase A Signaling Regulates p21-Activated Kinase Activation by Flow in Endothelial Cells. Circulation Research 2010, 106: 1394-1403. PMID: 20224042, PMCID: PMC2862370, DOI: 10.1161/circresaha.109.210286.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory AgentsBasement MembraneCattleCdc42 GTP-Binding ProteinCells, CulturedCyclic AMP-Dependent Protein KinasesEndothelial CellsEnzyme ActivationEnzyme ActivatorsHumansIloprostInflammationInflammation MediatorsInjections, IntraperitonealIntegrinsMaleMechanotransduction, CellularMiceMice, Inbred C57BLNF-kappa BP21-Activated KinasesPhosphorylationProtein Kinase InhibitorsPulsatile FlowRac GTP-Binding ProteinsRegional Blood FlowStress, MechanicalTime FactorsTransfectionConceptsInflammatory gene expressionNF-kappaB activationInflammatory signalingEndothelial cellsProstacyclin analogue iloprostBasement membrane proteinsBlood flow patternsPKA-dependent inhibitionInflammatory pathwaysAnalogue iloprostGene expressionKappaB activationNF-kappaB.Subendothelial extracellular matrixNuclear factorPAK activationBasement membrane
2006
Matrix-specific Suppression of Integrin Activation in Shear Stress Signaling
Orr AW, Ginsberg MH, Shattil SJ, Deckmyn H, Schwartz MA. Matrix-specific Suppression of Integrin Activation in Shear Stress Signaling. Molecular Biology Of The Cell 2006, 17: 4686-4697. PMID: 16928957, PMCID: PMC1635406, DOI: 10.1091/mbc.e06-04-0289.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood VesselsCattleCyclic AMP-Dependent Protein KinasesEndothelial CellsEnzyme ActivationExtracellular MatrixFibroblast Growth Factor 2FibronectinsIntegrin alpha2beta1Integrin alpha5beta1Integrin alphaVbeta3Models, BiologicalPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesProtein Kinase CSignal TransductionStress, MechanicalTalin