1995
Inhibition of Cell Cycle Progression by the Alternatively Spliced Integrin β1C
Meredith J, Takada Y, Fornaro M, Languino L, Schwartz M. Inhibition of Cell Cycle Progression by the Alternatively Spliced Integrin β1C. Science 1995, 269: 1570-1572. PMID: 7545312, DOI: 10.1126/science.7545312.Peer-Reviewed Original ResearchMapping in vivo associations of cytoplasmic proteins with integrin beta 1 cytoplasmic domain mutants.
Lewis J, Schwartz M. Mapping in vivo associations of cytoplasmic proteins with integrin beta 1 cytoplasmic domain mutants. Molecular Biology Of The Cell 1995, 6: 151-160. PMID: 7540435, PMCID: PMC275825, DOI: 10.1091/mbc.6.2.151.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsActininAmino Acid SequenceAnimalsBinding SitesCell Adhesion MoleculesChickensCytoplasmCytoskeletal ProteinsFluorescent Antibody TechniqueFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesIntegrin beta1IntegrinsMacromolecular SubstancesMiceMolecular Sequence DataMutagenesisProtein-Tyrosine KinasesRecombinant ProteinsSequence DeletionTalinVinculinConceptsFocal adhesion kinaseBeta 1 integrinC-terminusCytoplasmic proteinsF-actinMutant beta 1Entire cytoplasmic domainCytoplasmic domain mutantsSpecific cytoskeletal proteinsBeta 1Wild-type integrinCultured mouse fibroblastsBeta 1 integrin subunitActin cytoskeletonFocal adhesionsCytoplasmic domainDomain mutantsAdhesion kinaseAlpha-actininTrigger intracellularVivo associationCytoskeletal proteinsTalinFocal contactsAmino acids
1994
Alpha v integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion
Schwartz M, Denninghoff K. Alpha v integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion. Journal Of Biological Chemistry 1994, 269: 11133-11137. PMID: 7512559, DOI: 10.1016/s0021-9258(19)78101-0.Peer-Reviewed Original ResearchConceptsAlpha 5 beta 1Alpha vBeta 1Intracellular calciumEndothelial cellsAnti-integrin monoclonal antibodiesElevation of intracellularAlpha v integrinsAnti-integrin antibodiesMonoclonal antibodiesV integrinsAntibodiesDistinct intracellularAgonistsIntegrin alpha subunitsAdhesion assaysFunction-blocking anti-integrin antibodiesIntegrinsSpecific integrinsCalciumFibronectinAlpha subunitCellsSame cellsIntracellular
1993
Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms.
Leavesley D, Schwartz M, Rosenfeld M, Cheresh D. Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. Journal Of Cell Biology 1993, 121: 163-170. PMID: 7681432, PMCID: PMC2119781, DOI: 10.1083/jcb.121.1.163.Peer-Reviewed Original ResearchConceptsExtracellular calciumBeta 3Extracellular calcium sourcesAlpha v beta 3Alpha 2 beta 1Absence of cytokinesNa/H antiporterBeta 1 mAbIntracellular calciumCalcium influxIntegrin alpha 2 beta 1Specific influxBeta 1Distinct signaling mechanismsEndothelial cell migrationGrowth factorMeasurable riseDistinct intracellularRespective integrinsH antiporterCellular migrationCell migrationCell contactCalciumMAbs
1991
Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape.
Schwartz M, Lechene C, Ingber D. Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 7849-7853. PMID: 1652767, PMCID: PMC52401, DOI: 10.1073/pnas.88.17.7849.Peer-Reviewed Original ResearchConceptsIntegrin alpha 5 beta 1Alpha 5 beta 1Cell shapeInsoluble extracellular matrix moleculesNa/H antiporterExtracellular matrix receptorsInsoluble fibronectinSurface-adsorbed fibronectinSoluble growth factorsExtracellular matrix moleculesH antiporterCell surface receptorsTransmembrane receptorsGrowth factor receptorBeta 1Matrix receptorsGrowth controlAnchorage-dependent cellsMatrix moleculesAntiporterFactor receptorSuppress growthSoluble mitogensGrowth factorFibronectinMultiple integrins share the ability to induce elevation of intracellular pH
Schwartz M, Ingber D, Lawrence M, Springer T, Lechene C. Multiple integrins share the ability to induce elevation of intracellular pH. Experimental Cell Research 1991, 195: 533-535. PMID: 1712734, DOI: 10.1016/0014-4827(91)90407-l.Peer-Reviewed Original ResearchConceptsBovine capillary endothelial cellsElevation of pHiAlpha v beta 3Alpha 5 beta 1Capillary endothelial cellsElevation of intracellularT cell receptor complexIntegrin alpha v beta 3Human T lymphocytesPeripheral human T lymphocytesNa-H antiporterCollagen type IIICell receptor complexIntegrin familyT cellsT lymphocytesSignificant elevationIntegrin LFA-1Integrin alpha 5 beta 1LFA-1ICAM-2Endothelial cellsBeta 1Beta 3Antibodies