2015
Novel RAAS agonists and antagonists: clinical applications and controversies
Romero CA, Orias M, Weir MR. Novel RAAS agonists and antagonists: clinical applications and controversies. Nature Reviews Endocrinology 2015, 11: 242-252. PMID: 25666495, PMCID: PMC7097622, DOI: 10.1038/nrendo.2015.6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAngiotensin receptor blockersRelative risk reductionBlood pressure homeostasisRAAS peptidesAldosterone systemReceptor blockersCardiorenal diseaseVascular injuryPressure homeostasisReceptor densityTarget organsAutocrine systemEnzyme inhibitorsVascular structuresClinical applicationRisk reductionVariety of sitesHaemodynamicsBlockersAgonistsInjuryAntagonistRAASDiseasePeptides
2000
KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels
Lang R, Lee G, Liu W, Tian S, Rafi H, Orias M, Segal A, Desir G. KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. American Journal Of Physiology. Renal Physiology 2000, 278: f1013-f1021. PMID: 10836990, DOI: 10.1152/ajprenal.2000.278.6.f1013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCyclic Nucleotide-Gated Cation ChannelsDNA PrimersFemaleHumansIn Vitro TechniquesIon Channel GatingIon ChannelsMembrane PotentialsOocytesPatch-Clamp TechniquesPotassium Channel BlockersPotassium ChannelsPotassium Channels, Voltage-GatedRabbitsRecombinant ProteinsSecond Messenger SystemsShaker Superfamily of Potassium ChannelsXenopus laevis
1997
Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments
Orias M, Velázquez H, Tung F, Lee G, Desir G. Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments. American Journal Of Physiology 1997, 273: f663-f666. PMID: 9362344, DOI: 10.1152/ajprenal.1997.273.4.f663.Peer-Reviewed Original ResearchConceptsThick ascending limbAscending limbK channelsCortical thick ascending limbMedullary thick ascending limbDistal nephron segmentsReverse transcription-polymerase chain reactionDistal convoluted tubuleTranscription-polymerase chain reactionDistal tubulesConvoluted tubulesProximal tubulesNephron segmentsHigh expressionNephron segment localizationK homeostasisChain reactionHuman kidney cDNATubulesSegment localizationExclusive expressionKCNK1LimbPore regionKidney cDNA