1999
The effects of naltrexone maintenance on the response to yohimbine in healthy volunteers
Rosen M, Kosten T, Kreek M. The effects of naltrexone maintenance on the response to yohimbine in healthy volunteers. Biological Psychiatry 1999, 45: 1636-1645. PMID: 10376126, DOI: 10.1016/s0006-3223(98)00259-5.Peer-Reviewed Original ResearchConceptsWeeks of treatmentDrug effectsStrongest drug effectsOpioid antagonist naltrexoneActive naltrexoneNaltrexone treatmentNaltrexone maintenanceAntagonist naltrexoneHealthy subjectsHealthy volunteersWeek 1Week 2Cortisol levelsYohimbineWeek 5PlaceboPreclinical researchNaltrexoneAlters sensitivityEffect of pretreatmentWeeksAntagonistTreatmentStress responsivenessSubjects
1998
The effect of lamotrigine on naloxone-precipitated opiate withdrawal
Rosen M, Pearsall H, Kosten T. The effect of lamotrigine on naloxone-precipitated opiate withdrawal. Drug And Alcohol Dependence 1998, 52: 173-176. PMID: 9800147, DOI: 10.1016/s0376-8716(98)00057-x.Peer-Reviewed Original Research
1995
The Severity of Naloxone-Precipitated Opiate Withdrawal Is Attenuated by Felbamate, a Possible Glycine Antagonist
Kosten T, DeCaprio J, Rosen M. The Severity of Naloxone-Precipitated Opiate Withdrawal Is Attenuated by Felbamate, a Possible Glycine Antagonist. Neuropsychopharmacology 1995, 13: 323-333. PMID: 8747757, DOI: 10.1016/0893-133x(95)00065-l.Peer-Reviewed Original ResearchConceptsNaloxone-precipitated opiate withdrawalDose-related mannerOpiate withdrawalWithdrawal severityN-methyl-D-aspartate (NMDA) receptor systemPartial agonistOverall withdrawal severityGlycinergic agentsPenile groomingWithdrawal signsOpiate detoxificationHA-966NMDA antagonistsRostral medullaGlycine antagonistLow dosePotential treatmentPutative antagonistNMDA channelsClinical useReceptor systemAntagonistTeeth chatterD-cycloserineSeverity
1992
Buprenorphine for Opioid and Cocaine Dependence
Rosen M, Kosten T. Buprenorphine for Opioid and Cocaine Dependence. Drug And Alcohol Abuse Reviews 1992, 137-147. DOI: 10.1007/978-1-4612-0359-9_7.Peer-Reviewed Original ResearchBuprenorphine for cocaine and opiate dependence.
Kosten T, Rosen M, Schottenfeld R, Ziedonis D. Buprenorphine for cocaine and opiate dependence. Psychopharmacology Bulletin 1992, 28: 15-9. PMID: 1609037.Peer-Reviewed Original ResearchConceptsCocaine abuseMixed opioid agonist/antagonistOpioid agonist/antagonistPreliminary human studiesAgonists/antagonistsBuprenorphine treatmentOpioid dependenceMethadone maintenanceClinical trialsConcurrent dependencePreclinical studiesCocaine effectsBuprenorphineHuman studiesPlace preferenceChallenge studiesCocaineMethadoneTreatmentTrialsAbuseDose dependenceOpioidsAntagonistDaily