2024
TLR8‐activating miR‐146a‐3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS
Georges H, Cassin C, Tong M, Abrahams V. TLR8‐activating miR‐146a‐3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS. Immunology 2024, 172: 577-587. PMID: 38631842, PMCID: PMC11223956, DOI: 10.1111/imm.13794.Peer-Reviewed Original ResearchMiR-146a-3pPreterm birthFetal membranesToll-like receptorsExpression of miR-146a-3pLipopolysaccharide exposureMouse model of pregnancyIL-8Response to bacterial LPSAssociated with chorioamnionitisFetal membrane inflammationHuman FM explantsMouse fetal membranesInduced preterm birthBacterial lipopolysaccharideMaternal-fetal interfaceDanger signalsWild-type miceIn vivo mouse modelModel of pregnancyInterleukin (IL)-8Pro-inflammatory roleResponse to bacterial lipopolysaccharideAssociated with elevated levelsResponse to LPS
2020
Viral infection dampens human fetal membrane type I interferon responses triggered by bacterial LPS
Potter JA, Tong M, Aldo P, Kwon JY, Pitruzzello M, Mor G, Abrahams VM. Viral infection dampens human fetal membrane type I interferon responses triggered by bacterial LPS. Journal Of Reproductive Immunology 2020, 140: 103126. PMID: 32289593, PMCID: PMC7299810, DOI: 10.1016/j.jri.2020.103126.Peer-Reviewed Original ResearchConceptsType I IFNsMaternal-fetal interfaceI IFNsAbility of LPSMouse fetal membranesI interferonFetal membranesViral infectionMHV-68IRF-7LPS treatmentBacterial LPSType I IFN productionLow-dose LPSPrior viral infectionΓ-herpes virusMHV-68 infectionPregnant C57BL/6 miceI IFN productionType I interferonHuman fetal membranesDose LPSInnate immune strategiesC57BL/6 miceIFN production
2019
Neutrophil Activation and Extracellular Trap Formation at the Fetal Membranes: Relevance for Preterm Birth
Tong M. Neutrophil Activation and Extracellular Trap Formation at the Fetal Membranes: Relevance for Preterm Birth. Placenta 2019, 83: e6-e7. DOI: 10.1016/j.placenta.2019.06.024.Peer-Reviewed Original ResearchLipopolysaccharide-Stimulated Human Fetal Membranes Induce Neutrophil Activation and Release of Vital Neutrophil Extracellular Traps.
Tong M, Potter JA, Mor G, Abrahams VM. Lipopolysaccharide-Stimulated Human Fetal Membranes Induce Neutrophil Activation and Release of Vital Neutrophil Extracellular Traps. The Journal Of Immunology 2019, 203: 500-510. PMID: 31167775, PMCID: PMC6616008, DOI: 10.4049/jimmunol.1900262.Peer-Reviewed Original ResearchConceptsNeutrophil extracellular trapsNeutrophil recruitmentFetal membranesReactive oxygen species productionPreterm birthExtracellular trapsOxygen species productionCytokine/chemokine secretionChemokine/cytokine productionMajor risk factorSpecies productionBacterial LPS stimulationNeutrophil infiltrationProinflammatory factorsFetal interfaceChemokine secretionNeonatal mortalityCytokine productionNeutrophil activationRisk factorsTissue injuryNeutrophil viabilityLPS stimulationEx vivoNET formation
2017
Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation.
Cross SN, Potter JA, Aldo P, Kwon JY, Pitruzzello M, Tong M, Guller S, Rothlin CV, Mor G, Abrahams VM. Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation. The Journal Of Immunology 2017, 199: 2885-2895. PMID: 28916522, PMCID: PMC5659726, DOI: 10.4049/jimmunol.1700870.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedChorioamnionitisC-Mer Tyrosine KinaseExtraembryonic MembranesFemaleGammaherpesvirinaeHerpesviridae InfectionsHerpesvirus 2, HumanHumansImmunizationInflammasomesIntercellular Signaling Peptides and ProteinsInterleukin-1betaLipopolysaccharidesMiceMice, Inbred C57BLMice, KnockoutPregnancyPremature BirthProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesConceptsFetal membranesViral infectionImmune responseTAM receptorsSubsequent preterm birthAdverse pregnancy outcomesIL-1β productionIL-1β responseHerpes viral infectionsInnate immune responseVivo mouse modelHuman fetal membranesAggravated inflammationIL-1β processingPregnancy outcomesPreterm birthAssociated complicationsPremature rupturePregnant womenLocal infectionInflammasome activationMerTK inhibitionMouse modelBacterial LPSLigand expression