Featured Publications
Short-term consumption of highly processed diets varying in macronutrient content impair the sense of smell and brain metabolism in mice
Makhlouf M, Souza D, Kurian S, Bellaver B, Ellis H, Kuboki A, Al-Naama A, Hasnah R, Venturin G, da Costa J, Venugopal N, Manoel D, Mennella J, Reisert J, Tordoff M, Zimmer E, Saraiva L. Short-term consumption of highly processed diets varying in macronutrient content impair the sense of smell and brain metabolism in mice. Molecular Metabolism 2023, 79: 101837. PMID: 37977411, PMCID: PMC10724696, DOI: 10.1016/j.molmet.2023.101837.Peer-Reviewed Original ResearchConceptsMacronutrient contentIncrease food safetyGrain-based dietShort-term consumptionElectro-olfactogramFood safetyProcessed dietsFood processingBrain regionsBrain metabolismOdor-guided behaviorStandard chow dietShort-term intakeDietGlucose metabolism imagingHigh-fat dietFoodResponses to odorantsBrain glucose metabolismOlfactory mucosaModern dietFood consumptionChow dietChronic consumptionMetabolic phenotypeIdentifying candidate genes underlying isolated congenital anosmia
Kamarck M, Trimmer C, Murphy N, Gregory K, Manoel D, Logan D, Saraiva L, Mainland J. Identifying candidate genes underlying isolated congenital anosmia. Clinical Genetics 2023, 105: 376-385. PMID: 38148624, PMCID: PMC10932857, DOI: 10.1111/cge.14470.Peer-Reviewed Original ResearchConceptsIsolated congenital anosmiaWhole-exome sequencingCongenital anosmiaGene candidate listsLoss-of-function variantsSpectrum of genetic alterationsOlfactory transduction pathwayZinc ion bindingDeleterious variantsExome sequencingTransduction pathwaysGenetic alterationsOlfactory signalsNon-syndromicOlfactory functionAssociated with olfactionQuality of lifeGenesAnosmiaIon bindingEstimated 1VariantsOlfactionFamilyCNGA2A 3D transcriptomics atlas of the mouse nose sheds light on the anatomical logic of smell
Ruiz Tejada Segura M, Abou Moussa E, Garabello E, Nakahara T, Makhlouf M, Mathew L, Wang L, Valle F, Huang S, Mainland J, Caselle M, Osella M, Lorenz S, Reisert J, Logan D, Malnic B, Scialdone A, Saraiva L. A 3D transcriptomics atlas of the mouse nose sheds light on the anatomical logic of smell. Cell Reports 2022, 38: 110547. PMID: 35320714, PMCID: PMC8995392, DOI: 10.1016/j.celrep.2022.110547.Peer-Reviewed Original ResearchDeconstructing the mouse olfactory percept through an ethological atlas
Manoel D, Makhlouf M, Arayata C, Sathappan A, Da'as S, Abdelrahman D, Selvaraj S, Hasnah R, Mainland J, Gerkin R, Saraiva L. Deconstructing the mouse olfactory percept through an ethological atlas. Current Biology 2021, 31: 2809-2818.e3. PMID: 33957076, PMCID: PMC8282700, DOI: 10.1016/j.cub.2021.04.020.Peer-Reviewed Original ResearchConceptsOlfactory perceptionMouse behaviorStudy of olfactory perceptionOdor perceptionBehavioral responsesPhysicochemical properties of odorantsHuman odor perceptionProperties of odorantsOdor identityOlfactory behaviorTarget odorOdorOdor concentrationPerceptionMiceBehaviorNon-humanResponseMultiple concentrationsCombinatorial effects of odorants on mouse behavior
Saraiva L, Kondoh K, Ye X, Yoon K, Hernandez M, Buck L. Combinatorial effects of odorants on mouse behavior. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e3300-e3306. PMID: 27208093, PMCID: PMC4988607, DOI: 10.1073/pnas.1605973113.Peer-Reviewed Original ResearchConceptsTrace amine-associated receptorsOdor aversionBehavioral effectsInstinctive behavioral responsesBinary odor mixturesEffects of odorsOdorant receptorsAversive responsesPredator odorMouse behaviorOdor stimuliOdor mixturesOdor responsesOdor perceptionReceptor antagonismBehavioral responsesOdor detectionSingle receptorSensory inputInstinctive behaviorAversionOdorStereotyped natureReceptor inputMouse noseA Large-Scale Analysis of Odor Coding in the Olfactory Epithelium
Nara K, Saraiva L, Ye X, Buck L. A Large-Scale Analysis of Odor Coding in the Olfactory Epithelium. Journal Of Neuroscience 2011, 31: 9179-9191. PMID: 21697369, PMCID: PMC3758579, DOI: 10.1523/jneurosci.1282-11.2011.Peer-Reviewed Original ResearchConceptsOlfactory sensory neuronsOdor qualityOdor recognitionMouse olfactory sensory neuronsOdorant receptorsEncode odor identityExpressed odorant receptorOdor identityOdor codingOlfactory epitheliumSensory neuronsPerceived odorMultiple odorantsSensory inputInnate behaviorsOdorLarge-scale analysisOR genesMiceCombinatorial code
2020
Recent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms
Gerkin R, Ohla K, Veldhuizen M, Joseph P, Kelly C, Bakke A, Steele K, Farruggia M, Pellegrino R, Pepino M, Bouysset C, Soler G, Pereda-Loth V, Dibattista M, Cooper K, Croijmans I, Di Pizio A, Ozdener M, Fjaeldstad A, Lin C, Sandell M, Singh P, Brindha V, Olsson S, Saraiva L, Ahuja G, Alwashahi M, Bhutani S, D’Errico A, Fornazieri M, Golebiowski J, Hwang L, Öztürk L, Roura E, Spinelli S, Whitcroft K, Faraji F, Fischmeister F, Heinbockel T, Hsieh J, Huart C, Konstantinidis I, Menini A, Morini G, Olofsson J, Philpott C, Pierron D, Shields V, Voznessenskaya V, Albayay J, Altundag A, Bensafi M, Bock M, Calcinoni O, Fredborg W, Laudamiel C, Lim J, Lundström J, Macchi A, Meyer P, Moein S, Santamaría E, Sengupta D, Dominguez P, Yanik H, Hummel T, Hayes J, Reed D, Niv M, Munger S, Parma V, Boesveldt S, de Groot J, Dinnella C, Freiherr J, Laktionova T, Marino S, Monteleone E, Nunez-Parra A, Abdulrahman O, Ritchie M, Thomas-Danguin T, Walsh-Messinger J, Al Abri R, Alizadeh R, Bignon E, Cantone E, Cecchini M, Chen J, Guàrdia M, Hoover K, Karni N, Navarro M, Nolden A, Mazal P, Rowan N, Sarabi-Jamab A, Archer N, Chen B, Di Valerio E, Feeney E, Frasnelli J, Hannum M, Hopkins C, Klein H, Mignot C, Mucignat C, Ning Y, Ozturk E, Peng M, Saatci O, Sell E, Yan C, Alfaro R, Cecchetto C, Coureaud G, Herriman R, Justice J, Kaushik P, Koyama S, Overdevest J, Pirastu N, Ramirez V, Roberts S, Smith B, Cao H, Wang H, Birindwa P, Baguma M. Recent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms. Chemical Senses 2020, 46: bjaa081. PMID: 33367502, PMCID: PMC7799216, DOI: 10.1093/chemse/bjaa081.Peer-Reviewed Original ResearchConceptsSmell lossOlfactory lossOlfactory recoveryCOVID-19 laboratory test outcomePredictors of COVID-19Visual analog scale ratingsVisual analog scaleC19+Assess symptomsYes/no-questionsRespiratory symptom onsetCardinal symptomsIllnessSymptomsRespiratory illnessBest predictorsC19 groupSymptom onsetParticipantsChemosensory abilitiesIndividualsPredictorsSymptomatic COVID-19Cross-sectional studyAnalog scaleMore Than Smell—COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis
Parma V, Ohla K, Veldhuizen M, Niv M, Kelly C, Bakke A, Cooper K, Bouysset C, Pirastu N, Dibattista M, Kaur R, Liuzza M, Pepino M, Schöpf V, Pereda-Loth V, Olsson S, Gerkin R, Domínguez P, Albayay J, Farruggia M, Bhutani S, Fjaeldstad A, Kumar R, Menini A, Bensafi M, Sandell M, Konstantinidis I, Di Pizio A, Genovese F, Öztürk L, Thomas-Danguin T, Frasnelli J, Boesveldt S, Saatci Ö, Saraiva L, Lin C, Golebiowski J, Hwang L, Ozdener M, Guàrdia M, Laudamiel C, Ritchie M, Havlícek J, Pierron D, Roura E, Navarro M, Nolden A, Lim J, Whitcroft K, Colquitt L, Ferdenzi C, Brindha E, Altundag A, Macchi A, Nunez-Parra A, Patel Z, Fiorucci S, Philpott C, Smith B, Lundström J, Mucignat C, Parker J, van den Brink M, Schmuker M, Fischmeister F, Heinbockel T, Shields V, Faraji F, Santamaría E, Fredborg W, Morini G, Olofsson J, Jalessi M, Karni N, D’Errico A, Alizadeh R, Pellegrino R, Meyer P, Huart C, Chen B, Soler G, Alwashahi M, Welge-Lüssen A, Freiherr J, de Groot J, Klein H, Okamoto M, Singh P, Hsieh J, Reed D, Hummel T, Munger S, Hayes J, Abdulrahman O, Dalton P, Yan C, Voznessenskaya V, Chen J, Sell E, Walsh-Messinger J, Archer N, Koyama S, Deary V, Roberts S, Yanik H, Albayrak S, Nováková L, Croijmans I, Mazal P, Moein S, Margulis E, Mignot C, Mariño S, Georgiev D, Kaushik P, Malnic B, Wang H, Seyed-Allaei S, Yoluk N, Razzaghi-Asl S, Justice J, Restrepo D. More Than Smell—COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis. Chemical Senses 2020, 45: 609-622. PMID: 32564071, PMCID: PMC7337664, DOI: 10.1093/chemse/bjaa041.Peer-Reviewed Original ResearchConceptsChemosensory impairmentSmell lossAssociated with severe impairmentSelf-reported quantityNasal obstructionOlfactory abilityDifference scoresChemosensory modalitiesSevere impairmentPerceived nasal obstructionImpairmentClinical assessment groupClinical assessmentQuality of perceptionLaboratory testsInternational QuestionnaireReduction of smellParticipantsCOVID-19 diagnosisSmellObstructionCOVID-19Assessment Group
2014
Olfactory Receptor Patterning in a Higher Primate
Horowitz L, Saraiva L, Kuang D, Yoon K, Buck L. Olfactory Receptor Patterning in a Higher Primate. Journal Of Neuroscience 2014, 34: 12241-12252. PMID: 25209267, PMCID: PMC4160765, DOI: 10.1523/jneurosci.1779-14.2014.Peer-Reviewed Original ResearchConceptsTrace amine-associated receptorsHuman trace amine-associated receptorDetect social cuesHuman olfactory perceptionOdorant receptorsMammalian olfactory systemOrganization of sensory inputsSocial cuesOlfactory perceptionOlfactory bulbOlfactory systemSensory inputInstinctive behaviorMouse nosePrimatesDifferent domainsOrganizational strategiesReceptor patternsMacaquesReceptorsCuesChemosensory receptorsMiceOlfactionBrainThe Olfactory Transcriptomes of Mice
Ibarra-Soria X, Levitin M, Saraiva L, Logan D. The Olfactory Transcriptomes of Mice. PLOS Genetics 2014, 10: e1004593. PMID: 25187969, PMCID: PMC4154679, DOI: 10.1371/journal.pgen.1004593.Peer-Reviewed Original ResearchConceptsVomeronasal receptorsVR genesProtein-coding genesProtein coding sequencesDeep RNA sequencingDistribution of abundanceEvidence of expressionCell-specific expressionReference genomeGene annotationMultiple malesMulti-exonQuantitative catalogOlfactory tissueMouse genomeCoding sequenceOR genesOlfactory-mediated behaviorsGenomic techniquesExpression microarraysRNA sequencingGene expressionGenesQuantitative RT-PCRSexual dimorphism