2023
Genetic Variation and Sensory Perception of a Pediatric Formulation of Ibuprofen: Can a Medicine Taste Too Good for Some?
Mennella J, Kan M, Lowenthal E, Saraiva L, Mainland J, Himes B, Pepino M. Genetic Variation and Sensory Perception of a Pediatric Formulation of Ibuprofen: Can a Medicine Taste Too Good for Some? International Journal Of Molecular Sciences 2023, 24: 13050. PMID: 37685855, PMCID: PMC10487938, DOI: 10.3390/ijms241713050.Peer-Reviewed Original ResearchConceptsGenetic ancestryEuropean genetic ancestryTaste receptor genesIndependent of ancestryAfrican genetic ancestryGenetic variationFormulations of ibuprofenEpigenetic factorsAncestryReceptor geneDouble-blind cohort studyUrge to coughPerception of palatabilityRisk of accidental ingestionPersonality variationCohort studyPediatric formulationsSensory phenotypesThroat sensationChemesthetic sensationsMedicinal tasteTingling sensationPanelistsAdult panelistsDiverse populations
2017
Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated
Ibarra-Soria X, Nakahara T, Lilue J, Jiang Y, Trimmer C, Souza M, Netto P, Ikegami K, Murphy N, Kusma M, Kirton A, Saraiva L, Keane T, Matsunami H, Mainland J, Papes F, Logan D. Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated. ELife 2017, 6: e21476. PMID: 28438259, PMCID: PMC5404925, DOI: 10.7554/elife.21476.Peer-Reviewed Original ResearchConceptsOlfactory sensory neurons subtypesOlfactory sensory neuronsMouse olfactory sensory neuronsNeuronal diversityOlfactory receptorsOlfactory sensory systemTime-dependent mannerGenetically identical miceRNA sequencing-based methodsSub-stratifiedNeuronal repertoireSensory neuronsSubtype distributionIdentical miceOlfactory stimulationGenetic variationSubtypesMiceEnvironmental factorsDiversityReceptorsRepertoireSensory systemsNeurons